Showing entry for NAD-dependent histone deacetylase SIR2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006474
Protein NameNAD-dependent histone deacetylase SIR2
Uniport IdP06700
GeneSIR2
Gene Id851520
DomainDUF592; SIR2
Pfam PF04574   PF02146  
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006333 chromatin assembly or disassembly
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006348 chromatin silencing at telomere
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0097695 establishment of protein-containing complex localization to telomere
Biological Process GO:0031047 gene silencing by RNA
Biological Process GO:1904524 negative regulation of DNA amplification
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0008156 negative regulation of DNA replication
Biological Process GO:0000183 rDNA heterochromatin assembly
Biological Process GO:0097752 regulation of DNA stability
Biological Process GO:0001302 replicative cell aging
Biological Process GO:0030466 silent mating-type cassette heterochromatin assembly
Biological Process GO:0007062 sister chromatid cohesion
Biological Process GO:0034398 telomere tethering at nuclear periphery
molecular function GO:0046872 metal ion binding
molecular function GO:0070403 NAD+ binding
molecular function GO:0017136 NAD-dependent histone deacetylase activity
molecular function GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
molecular function GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
molecular function GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
molecular function GO:0016740 transferase activity
cellular component GO:0005677 chromatin silencing complex
cellular component GO:0005737 cytoplasm
cellular component GO:0000790 nuclear chromatin
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005720 nuclear heterochromatin
cellular component GO:0031618 nuclear pericentric heterochromatin
cellular component GO:0005730 nucleolus
cellular component GO:0005634 nucleus
cellular component GO:0030869 RENT complex
cellular component GO:0034967 Set3 complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0006125 Nicotinamide 122.12
BXGC0008174 3,4-Dihydro-2H-1-benzopyran-2-one 148.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein