Showing entry for Nicotinamide


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0006125
Compound NameNicotinamide
Structure
FormulaC6H6N2O
InchiKeyDFPAKSUCGFBDDF-UHFFFAOYSA-N
SMILESNC(=O)C1=CC=CN=C1
InchiInChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
IUPACpyridine-3-carboxamide
Molecular Weight122.12
Pubchem Id936
Chembl IdCHEMBL1140
Targets of Information Source
DrugBank DB02701
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P11439 BXGT007702 Exotoxin A reviewed - eta approved; investigational product of
P00338 BXGT005504 L-lactate dehydrogenase A chain reviewed Enzyme LDHA approved; investigational -
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 reviewed - PARP1 approved; investigational binder
Q9NXA8 BXGT021245 NAD-dependent protein deacylase sirtuin-5, mitochondrial reviewed Epigenetic regulator SIRT5 approved; investigational -
Q10588 BXGT013202 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 reviewed Enzyme BST1 approved; investigational product of
PDB NCA
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P11439 BXGT007702 Exotoxin A reviewed eta - - - - -
Q10588 BXGT013202 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 reviewed BST1 Enzyme - - - -
P29241 BXGT009323 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase reviewed - - - - -
O30124 BXGT004366 NAD-dependent protein deacylase 2 reviewed cobB2 - - - - -
Q9WYW0 BXGT022006 NAD-dependent protein deacetylase reviewed cobB - - 1000000 - -
P71817 BXGT011697 Steroid isomerase, putative unreviewed MT0785 - - - - -
Q7M0L1 BXGT017007 Exoenzyme C3 unreviewed - - - - -
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase reviewed NAMPT Signaling - - - -
Q9WYW0 BXGT022006 NAD-dependent protein deacetylase reviewed cobB - - - - -
P06700 BXGT006474 NAD-dependent histone deacetylase SIR2 reviewed SIR2 - - - - -
P53686 BXGT011011 NAD-dependent protein deacetylase HST2 reviewed HST2 - - - - -
P00760 BXGT005644 Cationic trypsin reviewed - - - - -
P9WPY1 BXGT012477 Chorismate synthase reviewed aroC - - - - -
O58586 BXGT004806 Uncharacterized protein PH0856 reviewed PH0856 - - - - -
P24627 BXGT008981 Lactotransferrin reviewed LTF - - - - -
Q8N8N7 BXGT018529 Prostaglandin reductase 2 reviewed PTGR2 Enzyme - - - -
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 reviewed CD38 Enzyme - - - -
Q93NH4 BXGT019514 6-hydroxy-L-nicotine oxidase unreviewed 6-hlno - - - - -
A0A0H2UR34 BXGT000265 Isochorismatase family protein unreviewed SP_1583 - - - - -
P40261 BXGT010170 Nicotinamide N-methyltransferase reviewed NNMT Enzyme - - - -
Q8K4Z3 BXGT018403 NAD(P)H-hydrate epimerase reviewed Naxe - - - - -
Q9H2K2 BXGT020454 Poly [ADP-ribose] polymerase tankyrase-2 reviewed TNKS2 - - - - -
A3LT82 BXGT001169 NADPH dehydrogenase unreviewed OYE2.6 - - - - -
Q8TLY9 BXGT018833 Uncharacterized protein unreviewed MA_2883 - - - - -
Q5NLA1 BXGT015616 NADH:flavin oxidoreductase unreviewed ZMO1885 - - - - -
P00588 BXGT005590 Diphtheria toxin reviewed - - - - -
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed SIRT2 Epigenetic regulator - - - -
P16094 BXGT008190 Ribosome-inactivating protein momordin I reviewed - - - - -
P01898 BXGT005810 H-2 class I histocompatibility antigen, Q10 alpha chain reviewed H2-Q10 - - - - -
A0A1L1QK40 BXGT000733 Cyclohexanone Monooxygenase from Thermocrispum municipale unreviewed - - - - -
P25321 BXGT009037 cAMP-dependent protein kinase catalytic subunit alpha reviewed PRKACA - - - - -
D0VWZ1 BXGT002754 Amidase unreviewed Nit2 - - - - -
P41816 BXGT010272 NADPH dehydrogenase 3 reviewed OYE3 - - - - -
B4G043 BXGT002132 Ferredoxin--NADP reductase, chloroplastic unreviewed 542713 - - - - -
Q9HWU9 BXGT020636 Probable dehydrogenase unreviewed PA4079 - - - - -
Q5ZTK4 BXGT015934 Ubiquitinating/deubiquitinating enzyme SdeA reviewed sdeA - - - - -
P11140 BXGT007657 Abrin-a reviewed - - - - -
Q06198 BXGT024352 RNA polymerase sigma-H factor reviewed algU - - - - -
Q13451 BXGT013356 Peptidyl-prolyl cis-trans isomerase FKBP5 reviewed FKBP5 Enzyme - - - -
Binding DB 27507
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006934 Poly [ADP-ribose] polymerase 1 reviewed PARP1 - 50119 - -
reviewed BXGT005275 Poly [ADP-ribose] polymerase 2 reviewed Parp2 - 208930 - -
reviewed BXGT018525 NAD-dependent protein deacetylase sirtuin-6 reviewed Epigenetic regulator SIRT6 - 189400 - -
reviewed BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 - 10500 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - 73000 - -
reviewed BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 - 6200 - -
reviewed BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 - 11000 - -
reviewed BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 - 100500 - -
reviewed BXGT021245 NAD-dependent protein deacylase sirtuin-5, mitochondrial reviewed Epigenetic regulator SIRT5 - >100000 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - 149000 - -
reviewed BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 - 6300 - -
reviewed BXGT018525 NAD-dependent protein deacetylase sirtuin-6 reviewed Epigenetic regulator SIRT6 - 184000 - -
reviewed BXGT018525 NAD-dependent protein deacetylase sirtuin-6 reviewed Epigenetic regulator SIRT6 - 200000 - -
reviewed BXGT006934 Poly [ADP-ribose] polymerase 1 reviewed PARP1 - 210000 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - 520000 - -
reviewed BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 - 32300 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - 50000 - -
reviewed BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 - 1200 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - <50000 - -
reviewed BXGT006474 NAD-dependent histone deacetylase SIR2 reviewed SIR2 - <50000 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - 100000 - -
reviewed BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 - 14000 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - 250000 - -
reviewed BXGT011011 NAD-dependent protein deacetylase HST2 reviewed HST2 - 91000 - -
reviewed BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 - 377000 - -
reviewed BXGT021245 NAD-dependent protein deacylase sirtuin-5, mitochondrial reviewed Epigenetic regulator SIRT5 - 46600 - -
reviewed BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 - 30000 - -
reviewed BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 - 90400 - -
CHEMBL CHEMBL1140
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 250000 nM
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 39810 nM
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 IC50 '=' 6200 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 IC50 '=' 10500 nM
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 Activity '=' 20 %
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 6513 nM
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 IC50 '=' 11000 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 25000 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 73000 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah IC50 '=' 3300 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 reviewed Epigenetic regulator SIRT6 IC50 '=' 184000 nM
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 IC50 '=' 6300 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 Inhibition - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Km '=' 2980000 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 reviewed - PARP1 IC50 '=' 210000 nM
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 520000 nM
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 IC50 '=' 32300 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 IC50 '=' 1200 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 Inhibition - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 2 nM
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 IC50 '=' 100500 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 IC50 '=' 100000 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 Inhibition '=' 10 %
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 100000 nM
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 IC50 '=' 14000 nM
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 90400 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Activity '<' 8 %
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Drug metabolism - - -
P31513 BXGT009546 Dimethylaniline monooxygenase [N-oxide-forming] 3 reviewed Enzyme FMO3 Drug metabolism - - -
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 Activity '=' 42 %
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P0A9J4 BXGT007191 2-dehydropantoate 2-reductase reviewed - panE Inhibition '=' 0 %
Q8I6E4 BXGT018230 NAD-dependent protein deacetylase unreviewed - SIR2RP1 IC50 '=' 39400 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
Q8I6E4 BXGT018230 NAD-dependent protein deacetylase unreviewed - SIR2RP1 IC50 '=' 40000 nM
Q9NXA8 BXGT021245 NAD-dependent protein deacylase sirtuin-5, mitochondrial reviewed Epigenetic regulator SIRT5 IC50 '>' 100000 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 FC '>' 5 -
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Drug metabolism - - -
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 IC50 '=' 30000 nM
P13726 BXGT007950 Tissue factor reviewed Receptor F3 Ki '=' 8000000 nM
P08709 BXGT006818 Coagulation factor VII reviewed Enzyme F7 Ki '=' 8000000 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 reviewed Epigenetic regulator SIRT6 Inhibition '>' 50 %
P06700 BXGT006474 NAD-dependent histone deacetylase SIR2 reviewed - SIR2 IC50 '<' 50000 nM
Q9NXA8 BXGT021245 NAD-dependent protein deacylase sirtuin-5, mitochondrial reviewed Epigenetic regulator SIRT5 IC50 '=' 46600 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 50000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 Inhibition '=' 0 %
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '<' 50000 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 149000 nM
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 FC '=' 8 -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P53686 BXGT011011 NAD-dependent protein deacetylase HST2 reviewed - HST2 IC50 '=' 91000 nM
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 Activity '=' 26 %
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 Activity '=' 71 %
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Vmax '=' 60 pmol/mg/min
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Drug metabolism - - -
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 reviewed Epigenetic regulator SIRT6 IC50 '=' 200000 nM
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 IC50 '=' 377000 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 Activity - - -
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 reviewed Epigenetic regulator SIRT6 Inhibition '=' 76 %
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed Epigenetic regulator SIRT3 Inhibition '=' 74 %
Q9NXA8 BXGT021245 NAD-dependent protein deacylase sirtuin-5, mitochondrial reviewed Epigenetic regulator SIRT5 Inhibition - - -
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 Inhibition '=' 83 %
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 88000 nM
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 IC50 '=' 118000 nM
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 Inhibition '=' 73 %
Q9NXA8 BXGT021245 NAD-dependent protein deacylase sirtuin-5, mitochondrial reviewed Epigenetic regulator SIRT5 Inhibition '=' 69 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00063 Saffron Crocus sativus Herbs and Spices
BXGF00101 Flaxseed Linum usitatissimum Herbs and Spices
BXGF00131 Parsley Petroselinum crispum Herbs and Spices
BXGF00141 Common pea Pisum sativum Pulses
BXGF00165 Common sage Salvia officinalis Herbs and Spices
BXGF00182 Cocoa bean Theobroma cacao Cocoa and cocoa products
BXGF00186 Fenugreek Trigonella foenum-graecum Herbs and Spices
BXGF00200 Mung bean Vigna radiata Pulses
BXGF00805 Mushrooms Vegetables
BXGF00810 Cereals and cereal products Cereals and cereal products
BXGF00852 Triaenophora rupestris Triaenophora rupestris Others
BXGF00926 Larix cajanderi Larix cajanderi Others
BXGF00979 Cistanche deserticola Cistanche deserticola Medicinal Plant
BXGF01010 Sextonia rubra Sextonia rubra Others
BXGF01045 Dioscorea japonica Dioscorea japonica Medicinal Plant
BXGF01264 Cedrus libani Cedrus libani Medicinal Plant
BXGF01297 Justicia paniculata Justicia paniculata Medicinal Plant
BXGF01340 Khaya ivorensis Khaya ivorensis Medicinal Plant
BXGF01425 Craspidospermum verticillatum Craspidospermum verticillatum Others
BXGF01472 Cerinthe minor Cerinthe minor Others
BXGF01502 Ixeris stolonifera Ixeris stolonifera Medicinal Plant
BXGF01535 Cephalaria grossheimii Cephalaria grossheimii Others
BXGF01638 Lotus japonicus Lotus japonicus Others
BXGF01679 Melaleuca rhaphiophylla Melaleuca rhaphiophylla Others
BXGF01726 Senecio renardii Senecio renardii Medicinal Plant
BXGF01760 Hypericum ascyron Hypericum ascyron Medicinal Plant
BXGF01789 Aristolochia zollingeriana Aristolochia zollingeriana Others
BXGF02237 Citrus wilsonii Citrus wilsonii Medicinal Plant
BXGF02294 Bartramia pomiformis Bartramia pomiformis Medicinal Plant
BXGF02815 Pinellia ternata Pinellia ternata Medicinal Plant
BXGF03230 Ehretia dicksonii Ehretia dicksonii Medicinal Plant
BXGF03645 Lycium barbarum Lycium barbarum Medicinal Plant
BXGF04079 Senna siamea Senna siamea Medicinal Plant
BXGF04094 Virola multinervia Virola multinervia Medicinal Plant
BXGF04303 Anemarrhena asphodeloides Anemarrhena asphodeloides Medicinal Plant
BXGF04909 Hippophae fructus Hippophae fructus Others
BXGF05015 Balanophora involucrata Balanophora involucrata Medicinal Plant
BXGF05094 Lupinus verbasciformis Lupinus verbasciformis Others
BXGF05600 Aframomum amaniense Aframomum amaniense Others
BXGF05714 Khaya senegalensis Khaya senegalensis Medicinal Plant
BXGF05756 Cistanche tubulosa Cistanche tubulosa Medicinal Plant
BXGF05795 Nama hispidum Nama hispidum Others
BXGF05900 Beilschmiedia anacardioides Beilschmiedia anacardioides Medicinal Plant
BXGF06206 Hydrangea macrophylla Hydrangea macrophylla Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease