Showing entry for Guanine nucleotide-binding protein G(i) subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006820
Protein NameGuanine nucleotide-binding protein G(i) subunit alpha
Uniport IdP08754
GeneGNAI3
Gene Id2773
DomainG-alpha
Pfam PF00503  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.2 Endocrine system hsa04914 Progesterone-mediated oocyte maturation
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04916 Melanogenesis
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
6. Human Diseases 6.5 Substance dependence hsa05030 Cocaine addiction
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05142 Chagas disease (American trypanosomiasis)
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0007420 brain development
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0007212 dopamine receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0046039 GTP metabolic process
Biological Process GO:0007194 negative regulation of adenylate cyclase activity
Biological Process GO:2001234 negative regulation of apoptotic signaling pathway
Biological Process GO:0016239 positive regulation of macroautophagy
Biological Process GO:0033864 positive regulation of NAD(P)H oxidase activity
Biological Process GO:0032930 positive regulation of superoxide anion generation
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0006457 protein folding
Biological Process GO:0006906 vesicle fusion
molecular function GO:0019003 GDP binding
molecular function GO:0031683 G-protein beta/gamma-subunit complex binding
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0031821 G protein-coupled serotonin receptor binding
molecular function GO:0032794 GTPase activating protein binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0019904 protein domain specific binding
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005834 heterotrimeric G-protein complex
cellular component GO:0005765 lysosomal membrane
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0030496 midbody
cellular component GO:0005886 plasma membrane
cellular component GO:0042588 zymogen granule
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-111885 Opioid Signalling
R-HSA-112040 G-protein mediated events
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-202040 G-protein activation
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392499 Metabolism of proteins
R-HSA-392518 Signal amplification
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-5663205 Infectious disease
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-977443 GABA receptor activation
R-HSA-977443 GABA receptor activation
R-HSA-977444 GABA B receptor activation
R-HSA-977444 GABA B receptor activation
R-HSA-991365 Activation of GABAB receptors
R-HSA-991365 Activation of GABAB receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0003090 BXGD000175 Ankylosis Musculoskeletal Diseases
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0025988 BXGD001883 Microglossia Stomatognathic Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0037384 BXGD002693 Snoring Pathological Conditions, Signs and Symptoms
C0040433 BXGD002865 Tooth Crowding Stomatognathic Diseases
C0078917 BXGD003054 Albinism, Ocular Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0233750 BXGD004608 Hysterical amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0233796 BXGD004619 Temporary Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0236795 BXGD004832 Dissociative Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0239043 BXGD004960 Difficulty chewing
C0239234 BXGD004974 Low set ears
C0239479 BXGD004982 Round face
C0262497 BXGD005249 Global Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0266060 BXGD005617 Anterior open bite Stomatognathic Diseases
C0266589 BXGD005698 Congenital ear anomaly NOS (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Otorhinolaryngologic Diseases
C0267048 BXGD005728 Glossoptosis Stomatognathic Diseases
C0342684 BXGD007525 Ocular albinism, type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0399570 BXGD008254 Mandibular condyle aplasia Musculoskeletal Diseases; Stomatognathic Diseases
C0399572 BXGD008255 Hypoplasia of mandibular condyle Musculoskeletal Diseases; Stomatognathic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0431420 BXGD008688 Vein of Galen aneurysm Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0431478 BXGD008692 Posteriorly rotated ear
C0431565 BXGD008695 Hamartoma of tongue Neoplasms; Stomatognathic Diseases
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0750906 BXGD010244 Tactile Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0750907 BXGD010245 Amnestic State Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306710 BXGD012372 Facial asymmetry Pathological Conditions, Signs and Symptoms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1845447 BXGD014747 Cupped ears (finding)
C1846460 BXGD014820 Abnormality of the outer ear
C1853406 BXGD015334 Difficulty in tongue movements
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1860816 BXGD016001 Preauricular skin tag
C1865295 BXGD016307 Auriculo-condylar syndrome Otorhinolaryngologic Diseases
C1865302 BXGD016308 Cleft at the superior portion of the pinna
C1865304 BXGD016309 Overfolding of the superior helices
C1865305 BXGD016310 Hypoplastic superior helix
C1865313 BXGD016311 Speech articulation difficulties
C1865318 BXGD016312 Abnormality of the temporomandibular joint
C1866231 BXGD016388 Full cheeks
C1876185 BXGD016564 Dysgnathia complex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4021376 BXGD020617 Cleft helix
C4021380 BXGD020619 Abnormality of the crus of the helix
C4022171 BXGD020891 Periauricular skin pits
C4024626 BXGD021349 Aplasia/Hypoplasia of the external ear
C4025323 BXGD021645 Postauricular skin tag
C4551488 BXGD023314 Bifid uvula
C4551996 BXGD023471 Auriculocondylar syndrome 1 Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein