adisease

Showing entry for Cleft Palate

General Disease Information
BXGD Id	BXGD000575
Disease Name	Cleft Palate
Disease CUI Id	C0008925
MeSH Codes	C16 C05 C07
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
Semantic Type	Congenital Abnormality
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:225 DOID:0080015
Disease Ontology Class Name	syndrome; physical disorder
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00755	BXGT003945	Protein Wnt-7a	7476	reviewed	Signaling
O14646	BXGT004079	Chromodomain-helicase-DNA-binding protein 1	1105	reviewed
O14770	BXGT004095	Homeobox protein Meis2	4212	reviewed	Enzyme
O14936	BXGT004114	Peripheral plasma membrane protein CASK	8573	reviewed	Kinase
O15111	BXGT004126	Inhibitor of nuclear factor kappa-B kinase subunit alpha	1147	reviewed	Kinase
O15119	BXGT004128	T-box transcription factor TBX3	6926	reviewed	Transcription factor
O15146	BXGT004131	Muscle, skeletal receptor tyrosine-protein kinase	4593	reviewed	Kinase
O15357	BXGT004156	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	3636	reviewed
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O43597	BXGT004602	Protein sprouty homolog 2	10253	reviewed	Signaling
O43683	BXGT004614	Mitotic checkpoint serine/threonine-protein kinase BUB1	699	reviewed	Kinase
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60566	BXGT004884	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	701	reviewed	Kinase
O75369	BXGT005119	Filamin-B	2317	reviewed
O75496	BXGT005132	Geminin	51053	reviewed
O76039	BXGT005171	Cyclin-dependent kinase-like 5	6792	reviewed	Kinase
O94766	BXGT005330	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	26229	reviewed	Enzyme
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O96028	BXGT005417	Histone-lysine N-methyltransferase NSD2	7468	reviewed	Epigenetic regulator
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00488	BXGT005552	Coagulation factor XIII A chain	2162	reviewed	Enzyme
P00742	BXGT005636	Coagulation factor X	2159	reviewed	Enzyme
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01148	BXGT005739	Progonadoliberin-1	2796	reviewed
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02708	BXGT005927	Acetylcholine receptor subunit alpha	1134	reviewed	Ion channel
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P07437	BXGT006624	Tubulin beta chain	203068	reviewed	Cellular structure
P07510	BXGT006631	Acetylcholine receptor subunit gamma	1146	reviewed	Ion channel
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08708	BXGT006817	40S ribosomal protein S17	6218	reviewed	Nucleic acid binding
P08754	BXGT006820	Guanine nucleotide-binding protein G(i) subunit alpha	2773	reviewed	Enzyme modulator
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11586	BXGT007723	C-1-tetrahydrofolate synthase, cytoplasmic	4522	reviewed	Enzyme
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12830	BXGT007852	Cadherin-1	999	reviewed
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P13631	BXGT007929	Retinoic acid receptor gamma	5916	reviewed	Nuclear receptor
P14678	BXGT008038	Small nuclear ribonucleoprotein-associated proteins B and B'	6628	reviewed	Nucleic acid binding
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P18440	BXGT008404	Arylamine N-acetyltransferase 1	9	reviewed	Enzyme
P21333	BXGT008638	Filamin-A	2316	reviewed
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P27482	BXGT009185	Calmodulin-like protein 3	810	reviewed	Calcium-binding protein
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	2562	reviewed	Ion channel
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36871	BXGT009936	Phosphoglucomutase-1	5236	reviewed
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38919	BXGT010072	Eukaryotic initiation factor 4A-III	9775	reviewed
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P42766	BXGT010337	60S ribosomal protein L35	11224	reviewed	Nucleic acid binding
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46937	BXGT010554	Transcriptional coactivator YAP1	10413	reviewed	Enzyme modulator
P48740	BXGT010659	Mannan-binding lectin serine protease 1	5648	reviewed	Enzyme
P49116	BXGT010678	Nuclear receptor subfamily 2 group C member 2	7182	reviewed	Nuclear receptor
P49761	BXGT010736	Dual specificity protein kinase CLK3	1198	reviewed	Kinase
P49914	BXGT010762	5-formyltetrahydrofolate cyclo-ligase	10588	reviewed	Enzyme
P50542	BXGT010808	Peroxisomal targeting signal 1 receptor	5830	reviewed	Transporter
P51532	BXGT010852	Transcription activator BRG1	6597	reviewed	Epigenetic regulator
P52788	BXGT010953	Spermine synthase	6611	reviewed
P54753	BXGT011073	Ephrin type-B receptor 3	2049	reviewed	Kinase
P54764	BXGT011078	Ephrin type-A receptor 4	2043	reviewed	Kinase
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P57059	BXGT011210	Serine/threonine-protein kinase SIK1	150094	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61224	BXGT011370	Ras-related protein Rap-1b	5908	reviewed	Enzyme modulator
P61978	BXGT011399	Heterogeneous nuclear ribonucleoprotein K	3190	reviewed	Enzyme
P62266	BXGT011416	40S ribosomal protein S23	6228	reviewed	Nucleic acid binding
P62834	BXGT011464	Ras-related protein Rap-1A	5906	reviewed	Enzyme modulator
P62857	BXGT011466	40S ribosomal protein S28	6234	reviewed	Nucleic acid binding
P63165	BXGT011506	Small ubiquitin-related modifier 1	7341	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P98160	BXGT012228	Basement membrane-specific heparan sulfate proteoglycan core protein	3339	reviewed	Enzyme modulator
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q01974	BXGT012628	Tyrosine-protein kinase transmembrane receptor ROR2	4920	reviewed	Kinase
Q02127	BXGT012635	Dihydroorotate dehydrogenase (quinone), mitochondrial	1723	reviewed	Enzyme
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06520	BXGT012880	Bile salt sulfotransferase	6822	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q07001	BXGT012907	Acetylcholine receptor subunit delta	1144	reviewed	Ion channel
Q07020	BXGT012914	60S ribosomal protein L18	6141	reviewed	Nucleic acid binding
Q08209	BXGT012968	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	5530	reviewed
Q09470	BXGT013037	Potassium voltage-gated channel subfamily A member 1	3736	reviewed	Ion channel
Q12959	BXGT013283	Disks large homolog 1	1739	reviewed	Receptor
Q13188	BXGT013324	Serine/threonine-protein kinase 3	6788	reviewed	Kinase
Q13363	BXGT013344	C-terminal-binding protein 1	1487	reviewed	Transcription factor
Q13415	BXGT013350	Origin recognition complex subunit 1	4998	reviewed	Nucleic acid binding
Q13464	BXGT013357	Rho-associated protein kinase 1	6093	reviewed	Kinase
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q13951	BXGT013407	Core-binding factor subunit beta	865	reviewed
Q14392	BXGT013465	Transforming growth factor beta activator LRRC32	2615	reviewed	Receptor
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q15029	BXGT013524	116 kDa U5 small nuclear ribonucleoprotein component	9343	reviewed	Enzyme
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15223	BXGT013551	Nectin-1	5818	reviewed
Q15392	BXGT013566	Delta(24)-sterol reductase	1718	reviewed	Enzyme
Q15465	BXGT013573	Sonic hedgehog protein	6469	reviewed
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q16828	BXGT013676	Dual specificity protein phosphatase 6	1848	reviewed
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q4KMG0	BXGT014850	Cell adhesion molecule-related/down-regulated by oncogenes	50937	reviewed
Q53EZ4	BXGT015010	Centrosomal protein of 55 kDa	55165	reviewed
Q5T8D3	BXGT015850	Acyl-CoA-binding domain-containing protein 5	91452	reviewed	Enzyme modulator
Q6PCD5	BXGT016464	E3 ubiquitin-protein ligase RFWD3	55159	reviewed	Enzyme
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8IYD8	BXGT018367	Fanconi anemia group M protein	57697	reviewed	Enzyme
Q8NFD5	BXGT018560	AT-rich interactive domain-containing protein 1B	57492	reviewed
Q8WVQ1	BXGT018996	Soluble calcium-activated nucleotidase 1	124583	reviewed
Q92794	BXGT019375	Histone acetyltransferase KAT6A	7994	reviewed	Enzyme
Q92854	BXGT019385	Semaphorin-4D	10507	reviewed	Signaling
Q93088	BXGT019458	Betaine--homocysteine S-methyltransferase 1	635	reviewed
Q969G3	BXGT019607	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	6605	reviewed
Q96PU5	BXGT019711	E3 ubiquitin-protein ligase NEDD4-like	23327	reviewed	Enzyme
Q96PY6	BXGT019712	Serine/threonine-protein kinase Nek1	4750	reviewed	Kinase
Q96T60	BXGT019745	Bifunctional polynucleotide phosphatase/kinase	11284	reviewed
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q99873	BXGT019972	Protein arginine N-methyltransferase 1	3276	reviewed	Epigenetic regulator
Q9BWP8	BXGT020153	Collectin-11	78989	reviewed	Surfactant
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9BZE4	BXGT020197	Nucleolar GTP-binding protein 1	23560	reviewed
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9H2M3	BXGT020456	S-methylmethionine--homocysteine S-methyltransferase BHMT2	23743	reviewed
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HBH9	BXGT020521	MAP kinase-interacting serine/threonine-protein kinase 2	2872	reviewed	Kinase
Q9NPD8	BXGT021152	Ubiquitin-conjugating enzyme E2 T	29089	reviewed
Q9NPI8	BXGT021161	Fanconi anemia group F protein	2188	reviewed
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9NRR6	BXGT021193	Phosphatidylinositol polyphosphate 5-phosphatase type IV	56623	reviewed
Q9NTI5	BXGT021212	Sister chromatid cohesion protein PDS5 homolog B	23047	reviewed	Nucleic acid binding
Q9NW38	BXGT021230	E3 ubiquitin-protein ligase FANCL	55120	reviewed	Enzyme
Q9UBM7	BXGT021657	7-dehydrocholesterol reductase	1717	reviewed	Enzyme
Q9UHD8	BXGT021698	Septin-9	10801	reviewed	Enzyme modulator
Q9UHF0	BXGT021699	Tachykinin-3	6866	reviewed
Q9UI95	BXGT021714	Mitotic spindle assembly checkpoint protein MAD2B	10459	reviewed
Q9UJU2	BXGT021730	Lymphoid enhancer-binding factor 1	51176	reviewed
Q9ULV1	BXGT021764	Frizzled-4	8322	reviewed	G-protein coupled receptor
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9UPP1	BXGT021800	Histone lysine demethylase PHF8	23133	reviewed
Q9UPZ9	BXGT021804	Serine/threonine-protein kinase ICK	22858	reviewed	Kinase
Q9Y219	BXGT022206	Protein jagged-2	3714	reviewed
Q9Y4D7	BXGT022275	Plexin-D1	23129	reviewed
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q96KN7	BXGT022801	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1	57096	reviewed	Enzyme modulator
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
Q7Z4S6	BXGT023001	Kinesin-like protein KIF21A	55605	reviewed	Cellular structure
Q92785	BXGT023424	Zinc finger protein ubi-d4	5977	reviewed	Enzyme
P56703	BXGT023722	Proto-oncogene Wnt-3	7473	reviewed	Signaling
Q99958	BXGT023732	Forkhead box protein C2	2303	reviewed	Transcription factor
Q15583	BXGT024027	Homeobox protein TGIF1	7050	reviewed	Enzyme
Q9H9S5	BXGT024623	Fukutin-related protein	79147	reviewed
A6NHR9	BXGT024875	Structural maintenance of chromosomes flexible hinge domain-containing protein 1	23347	reviewed
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
Q96MF2	BXGT025769	SH3 and cysteine-rich domain-containing protein 3	246329	reviewed
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed
P58215	BXGT026106	Lysyl oxidase homolog 3	84695	reviewed
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}