Showing entry for Beta-1,4-galactosyltransferase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008103
Protein NameBeta-1,4-galactosyltransferase 1
Uniport IdP15291
GeneB4GALT1
Gene Id2683
DomainGlyco_transf_7C; Glyco_transf_7N
Pfam PF02709   PF13733  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00052 Galactose metabolism
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00510 N-Glycan biosynthesis
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00515 Mannose type O-glycan biosynthesis
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0060055 angiogenesis involved in wound healing
Biological Process GO:0007339 binding of sperm to zona pellucida
Biological Process GO:0007155 cell adhesion
Biological Process GO:0045136 development of secondary sexual characteristics
Biological Process GO:0002064 epithelial cell development
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0006012 galactose metabolic process
Biological Process GO:0018146 keratan sulfate biosynthetic process
Biological Process GO:0005989 lactose biosynthetic process
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0009312 oligosaccharide biosynthetic process
Biological Process GO:0007341 penetration of zona pellucida
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
Biological Process GO:0006487 protein N-linked glycosylation
Biological Process GO:0060046 regulation of acrosome reaction
molecular function GO:0043014 alpha-tubulin binding
molecular function GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
molecular function GO:0048487 beta-tubulin binding
molecular function GO:0008378 galactosyltransferase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0004461 lactose synthase activity
molecular function GO:0030145 manganese ion binding
molecular function GO:0003945 N-acetyllactosamine synthase activity
molecular function GO:0035250 UDP-galactosyltransferase activity
cellular component GO:0035577 azurophil granule membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0030057 desmosome
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0030175 filopodium
cellular component GO:0005794 Golgi apparatus
cellular component GO:0032580 Golgi cisterna membrane
cellular component GO:0000139 Golgi membrane
cellular component GO:0000138 Golgi trans cisterna
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0030667 secretory granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1187000 Fertilization
R-HSA-1430728 Metabolism
R-HSA-1474165 Reproduction
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-1638074 Keratan sulfate/keratin metabolism
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-2534343 Interaction With Cumulus Cells And The Zona Pellucida
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
R-HSA-3781860 Diseases associated with N-glycosylation of proteins
R-HSA-3781865 Diseases of glycosylation
R-HSA-392499 Metabolism of proteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-4793953 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
R-HSA-5653890 Lactose synthesis
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-71387 Metabolism of carbohydrates
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-975577 N-Glycan antennae elongation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010964 BXGD000692 Dandy-Walker Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014130 BXGD000899 Endocrine System Diseases Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0201899 BXGD004056 Aspartate aminotransferase measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0557874 BXGD009444 Global developmental delay
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1846821 BXGD014841 Abnormality of coagulation
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931009 BXGD017935 Congenital disorder of glycosylation type 2D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002722 Nitrate 62
BXGC0003418 Undylic acid 324.18
BXGC0003993 Uridine diphosphate 404.16
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0018397 beta-1,4-mannan 180.06
BXGC0037697 Methyl Alpha-D-Mannoside 194.08
BXGC0042315 1,4-dioxane 88.05
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein