Showing entry for 1,4-dioxane


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0042315
Compound Name1,4-dioxane
Structure
FormulaC4H8O2
InchiKeyRYHBNJHYFVUHQT-UHFFFAOYSA-N
SMILESO1CCOCC1
InchiInChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
IUPAC
Molecular Weight88.05
Pubchem Id31275
Chembl IdCHEMBL453716
Targets of Information Source
DrugBank DB03316
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P00780 BXGT005652 Subtilisin Carlsberg reviewed - apr experimental -
Q9Y275 BXGT022223 Tumor necrosis factor ligand superfamily member 13B reviewed - TNFSF13B experimental -
Q9Y6I3 BXGT022330 Epsin-1 reviewed - EPN1 experimental -
P03316 BXGT006049 Structural polyprotein reviewed - - experimental -
P10600 BXGT007584 Transforming growth factor beta-3 proprotein reviewed Signaling TGFB3 experimental -
PDB DIO
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00780 BXGT005652 Subtilisin Carlsberg reviewed subC - - - - -
P70985 BXGT011683 Type-2 restriction enzyme BsoBI reviewed bsoBIR - - - - -
P59071 BXGT011259 Basic phospholipase A2 VRV-PL-VIIIa reviewed - - - - -
Q9YGA6 BXGT022381 Trehalose/maltose import ATP-binding protein MalK reviewed malK - - - - -
O88339 BXGT005269 Epsin-1 reviewed Epn1 - - - - -
Q58487 BXGT015190 Mevalonate kinase reviewed mvk - - - - -
P61586 BXGT011375 Transforming protein RhoA reviewed RHOA Enzyme modulator - - - -
Q9Y275 BXGT022223 Tumor necrosis factor ligand superfamily member 13B reviewed TNFSF13B - - - - -
P0C6Y5 BXGT007443 Replicase polyprotein 1ab reviewed rep - - - - -
P08037 BXGT006717 Beta-1,4-galactosyltransferase 1 reviewed B4GALT1 - - - - -
P32169 BXGT009604 Rhamnulose-1-phosphate aldolase reviewed rhaD - - - - -
P0C6U2 BXGT007433 Replicase polyprotein 1a reviewed 1a - - - - -
P81446 BXGT011949 Beta-galactoside-specific lectin 1 reviewed - - - - -
P9WMC1 BXGT012384 HTH-type transcriptional regulator EthR reviewed ethR - - - - -
Q16740 BXGT013664 ATP-dependent Clp protease proteolytic subunit, mitochondrial reviewed CLPP - - - - -
P10600 BXGT007584 Transforming growth factor beta-3 proprotein reviewed TGFB3 Signaling - - - -
Q7SIA0 BXGT017102 Transferase unreviewed - - - - -
P83702 BXGT011999 Enoyl-CoA hydratase unreviewed - - - - -
Q53W83 BXGT015029 2-dehydro-3-deoxygluconokinase reviewed kdgK - - - - -
Q9RA47 BXGT021435 Methylenetetrahydrofolate reductase unreviewed metF - - - - -
Q93UV9 BXGT019538 Protease unreviewed PROF - - - - -
P27285 BXGT009169 Structural polyprotein reviewed - - - - -
P78380 BXGT011841 Oxidized low-density lipoprotein receptor 1 reviewed OLR1 - - - - -
P0ACJ8 BXGT007267 cAMP-activated global transcriptional regulator CRP reviewed crp - - - - -
P08833 BXGT006827 Insulin-like growth factor-binding protein 1 reviewed IGFBP1 Enzyme modulator - - - -
P15291 BXGT008103 Beta-1,4-galactosyltransferase 1 reviewed B4GALT1 Enzyme - - - -
P13449 BXGT007910 Nitrile hydratase subunit beta reviewed nthB - - - - -
Q9V2J8 BXGT021866 GlgA glycogen synthase unreviewed PAB2292 - - - - -
O07347 BXGT004007 Signal recognition particle protein reviewed ffh - - - - -
Q6Q0L5 BXGT016488 Uncharacterized protein unreviewed A197 - - - - -
P18429 BXGT008402 Endo-1,4-beta-xylanase A reviewed xynA - - - - -
P00747 BXGT005639 Plasminogen reviewed PLG Enzyme - - - -
P9WFG9 BXGT012243 UPF0678 fatty acid-binding protein-like protein Rv0813c reviewed Rv0813c - - - - -
P14735 BXGT008042 Insulin-degrading enzyme reviewed IDE Enzyme - - - -
P26368 BXGT009106 Splicing factor U2AF 65 kDa subunit reviewed U2AF2 - - - - -
P01903 BXGT005814 HLA class II histocompatibility antigen, DR alpha chain reviewed HLA-DRA Immune response - - - -
O04986 BXGT003969 Non-symbiotic hemoglobin 1 reviewed HB1 - - - - -
O87014 BXGT005253 USG-1 protein homolog reviewed usg - - - - -
Q8DSE5 BXGT018027 Putative deoxycytidylate deaminase unreviewed comEB - - - - -
P21333 BXGT008638 Filamin-A reviewed FLNA - - - - -
P84078 BXGT012032 ADP-ribosylation factor 1 reviewed Arf1 - - - - -
Q7DD47 BXGT016964 Exodeoxyribonuclease unreviewed exoA - - - - -
Q7X4S4 BXGT017216 Cellulase 12A unreviewed cel12A - - - - -
O30409 BXGT004377 Tyrocidine synthase 3 reviewed tycC - - - - -
P0A9J4 BXGT007191 2-dehydropantoate 2-reductase reviewed panE - - - - -
Q6K1C5 BXGT016341 Serine protease unreviewed napA - - - - -
P15927 BXGT008174 Replication protein A 32 kDa subunit reviewed RPA2 - - - - -
P56524 BXGT011176 Histone deacetylase 4 reviewed HDAC4 Epigenetic regulator - - - -
P62330 BXGT011423 ADP-ribosylation factor 6 reviewed ARF6 - - - - -
O60271 BXGT004866 C-Jun-amino-terminal kinase-interacting protein 4 reviewed SPAG9 Enzyme modulator - - - -
P07254 BXGT006580 Chitinase A reviewed chiA - - - - -
P01558 BXGT005767 Heat-labile enterotoxin B chain reviewed cpe - - - - -
Q5SLS3 BXGT015820 Hypoxanthine phosphoribosyltransferase unreviewed TTHA0220 - - - - -
P61823 BXGT011385 Ribonuclease pancreatic reviewed RNASE1 - - - - -
Q57818 BXGT015137 Transcription elongation factor Spt5 reviewed spt5 - - - - -
P0C0Y8 BXGT007395 Reaction center protein L chain reviewed pufL - - - - -
Q813T7 BXGT017295 Corrinoid adenosyltransferase unreviewed BC_1479 - - - - -
Q2GB12 BXGT014072 Cytochrome P450 unreviewed Saro_0514 - - - - -
P26447 BXGT009114 Protein S100-A4 reviewed S100A4 Calcium-binding protein - - - -
Q5JDJ7 BXGT015435 1,4-alpha-glucan branching enzyme TK1436 reviewed TK1436 - - - - -
O24592 BXGT004228 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic reviewed VP14 - - - - -
P0C6Q5 BXGT007430 Toxin coregulated pilus biosynthesis protein F reviewed tcpF - - - - -
Q26966 BXGT013922 Trans-sialidase unreviewed - - - - -
P68168 BXGT011584 Non-legume hemoglobin reviewed - - - - -
Q7WTR6 BXGT017194 Cellobiose phosphorylase unreviewed - - - - -
P0AEL6 BXGT007322 Ferrienterobactin-binding periplasmic protein reviewed fepB - - - - -
B5U8Q1 BXGT002181 Nucleotide-sugar aminotransferase unreviewed CBU_0696 - - - - -
P0C0Y9 BXGT007396 Reaction center protein M chain reviewed pufM - - - - -
P0C0Y7 BXGT007394 Reaction center protein H chain reviewed puhA - - - - -
P16649 BXGT008252 General transcriptional corepressor TUP1 reviewed TUP1 - - - - -
P14697 BXGT008040 Acetoacetyl-CoA reductase reviewed phaB - - - - -
F2JXJ3 BXGT003238 L-lysine 6-oxidase reviewed lodA - - - - -
A0A0A8IK66 BXGT000115 Heparin-binding protein WGA16 unreviewed wga16 - - - - -
O25272 BXGT004247 Cag pathogenicity island protein (Cag18) unreviewed HP_0539 - - - - -
Q86925 BXGT017586 Structural polyprotein reviewed - - - - -
Q2TFW1 BXGT014219 Carboxylic ester hydrolase unreviewed - - - - -
Q4Z1L3 BXGT014931 Actin-1 reviewed PB000323.01.0 - - - - -
Q81PP9 BXGT017357 Kynurenine formamidase reviewed kynB - - - - -
Q9ULU4 BXGT021762 Protein kinase C-binding protein 1 reviewed ZMYND8 - - - - -
A9WHE0 BXGT001814 Antibiotic biosynthesis monooxygenase unreviewed Caur_2443 - - - - -
P96311 BXGT012173 Endoglucanase unreviewed celA - - - - -
P14174 BXGT007991 Macrophage migration inhibitory factor reviewed MIF - - - - -
O33272 BXGT004445 Possible conserved membrane or secreted protein unreviewed Rv2969c - - - - -
Q8GUD7 BXGT018184 Probable inactive chitinase-like protein LaCIC reviewed LACIC - - - - -
Q9ER97 BXGT020304 Neuroglobin reviewed Ngb - - - - -
I6XHI4 BXGT003710 Steroid 3-ketoacyl-CoA thiolase reviewed fadA5 - - - - -
Q41415 BXGT014572 Epoxide hydrolase unreviewed - - - - -
Q5SLM7 BXGT015812 Cell wall-binding endopeptidase-related protein unreviewed TTHA0266 - - - - -
Q9A8X3 BXGT020044 Glucose-fructose oxidoreductase unreviewed CC_1225 - - - - -
D3Q1D9 BXGT002895 ErfK/YbiS/YcfS/YnhG family protein unreviewed Snas_6095 - - - - -
Q74MJ7 BXGT016830 V-type ATP synthase alpha chain reviewed atpA - - - - -
Q74MS5 BXGT016832 NEQ263 unreviewed NEQ263 - - - - -
O60462 BXGT004876 Neuropilin-2 reviewed NRP2 - - - - -
P01031 BXGT005720 Complement C5 reviewed C5 Enzyme modulator - - - -
P26285 BXGT009098 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 reviewed PFKFB2 - - - - -
P39900 BXGT010148 Macrophage metalloelastase reviewed MMP12 Enzyme - - - -
Q8N5J2 BXGT018519 Ubiquitin carboxyl-terminal hydrolase MINDY-1 reviewed MINDY1 - - - - -
P54753 BXGT011073 Ephrin type-B receptor 3 reviewed EPHB3 Kinase - - - -
P13006 BXGT007871 Glucose oxidase reviewed gox - - - - -
A3DIH0 BXGT001142 Intracellular exo-alpha-(1->5)-L-arabinofuranosidase reviewed Cthe_2548 - - - - -
Q58192 BXGT015178 Transcription initiation factor IIB reviewed tfb - - - - -
P21549 BXGT008661 Serine--pyruvate aminotransferase reviewed AGXT Enzyme - - - -
P04133 BXGT006153 Hexon protein reviewed L3 - - - - -
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed HDAC8 Epigenetic regulator - - - -
X5FN71 BXGT022643 Non-structural protein 1 unreviewed NS1 - - - - -
Q9H9B1 BXGT020501 Histone-lysine N-methyltransferase EHMT1 reviewed EHMT1 Epigenetic regulator - - - -
F1CLG1 BXGT003205 Putative RTX-toxin unreviewed rtxA1 - - - - -
O35543 BXGT004534 Hematopoietic prostaglandin D synthase reviewed Hpgds - - - - -
A0A0M3PNA2 BXGT000583 Hyposensitive to light 7 unreviewed - - - - -
F2Q7T0 BXGT024126 Bifunctional cytochrome P450/NADPH--P450 reductase [Includes: Cytochrome P450 unreviewed - - - - -
Q9BXU0 BXGT024193 Testis-expressed protein 12 reviewed TEX12 - - - - -
A6TBN1 BXGT024594 Cytidine deaminase reviewed cdd - - - - -
A0A0A0Q7Z8 BXGT024763 Beta-lactamase unreviewed CKO00_24250 - - - - -
Q13501 BXGT013365 Sequestosome-1 reviewed SQSTM1 - - - - -
Q8ZNC4 BXGT024900 Putative diaminopimelate decarboxylase unreviewed STM2360 - - - - -
G9BY57 BXGT025652 Leaf-branch compost cutinase reviewed - - - - -
Q04771 BXGT012783 Activin receptor type-1 reviewed ACVR1 Kinase - - - -
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase reviewed QPCT Enzyme - - - -
Q8VEB2 BXGT026038 Protein salvador homolog 1 reviewed Sav1 - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL453716
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00204 Common grape Vitis vinifera Fruits
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease