Showing entry for Replication protein A 32 kDa subunit



                       
General Target Information
BXGT IdBXGT008174
Protein NameReplication protein A 32 kDa subunit
Uniport IdP15927
GeneRPA2
Gene Id6118
DomainRPA_C
Pfam PF08784  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03030 DNA replication
2. Genetic Information Processing 2.4 Replication and repair hsa03420 Nucleotide excision repair
2. Genetic Information Processing 2.4 Replication and repair hsa03430 Mismatch repair
2. Genetic Information Processing 2.4 Replication and repair hsa03440 Homologous recombination
2. Genetic Information Processing 2.4 Replication and repair hsa03460 Fanconi anemia pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006284 base-excision repair
Biological Process GO:0042769 DNA damage response, detection of DNA damage
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0070987 error-free translesion synthesis
Biological Process GO:0042276 error-prone translesion synthesis
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0036297 interstrand cross-link repair
Biological Process GO:0006298 mismatch repair
Biological Process GO:0031571 mitotic G1 DNA damage checkpoint
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:0006297 nucleotide-excision repair, DNA gap filling
Biological Process GO:0033683 nucleotide-excision repair, DNA incision
Biological Process GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
Biological Process GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
Biological Process GO:0006294 nucleotide-excision repair, preincision complex assembly
Biological Process GO:0006293 nucleotide-excision repair, preincision complex stabilization
Biological Process GO:0034502 protein localization to chromosome
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:2000001 regulation of DNA damage checkpoint
Biological Process GO:0010569 regulation of double-strand break repair via homologous recombination
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0000723 telomere maintenance
Biological Process GO:0032201 telomere maintenance via semi-conservative replication
Biological Process GO:0006283 transcription-coupled nucleotide-excision repair
Biological Process GO:0019985 translesion synthesis
molecular function GO:0003684 damaged DNA binding
molecular function GO:0019899 enzyme binding
molecular function GO:0098505 G-rich strand telomeric DNA binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0003697 single-stranded DNA binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0000785 chromatin
cellular component GO:0005662 DNA replication factor A complex
cellular component GO:0016604 nuclear body
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016605 PML body
Reactome
Pathway Id Pathway Name
R-HSA-110312 Translesion synthesis by REV1
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-110320 Translesion Synthesis by POLH
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-1474165 Reproduction
R-HSA-1500620 Meiosis
R-HSA-157579 Telomere Maintenance
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-174414 Processive synthesis on the C-strand of the telomere
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis
R-HSA-174437 Removal of the Flap Intermediate from the C-strand
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-180786 Extension of Telomeres
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371511 HSF1 activation
R-HSA-3371556 Cellular response to heat stress
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-5358508 Mismatch Repair
R-HSA-5358508 Mismatch Repair
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5655862 Translesion synthesis by POLK
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69166 Removal of the Flap Intermediate
R-HSA-69183 Processive synthesis on the lagging strand
R-HSA-69186 Lagging Strand Synthesis
R-HSA-69190 DNA strand elongation
R-HSA-69206 G1/S Transition
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73884 Base Excision Repair
R-HSA-73886 Chromosome Maintenance
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
R-HSA-73894 DNA Repair
R-HSA-73933 Resolution of Abasic Sites (AP sites)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-912446 Meiotic recombination
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007104 BXGD000427 Female Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0025267 BXGD001845 Multiple Endocrine Neoplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027662 BXGD002015 Multiple Endocrine Neoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200635 BXGD004041 Lymphocyte Count measurement
C0235653 BXGD004762 Malignant neoplasm of female breast Neoplasms; Skin and Connective Tissue Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512419 BXGD013189 Hereditary Melanoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C2828150 BXGD017802 HPV positive oropharyngeal squamous cell carcinoma
C3160738 BXGD018472 FANCONI ANEMIA, COMPLEMENTATION GROUP D2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042315 1,4-dioxane 88.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein