Showing entry for Serine hydroxymethyltransferase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009768
Protein NameSerine hydroxymethyltransferase, mitochondrial
Uniport IdP34897
GeneSHMT2
Gene Id6472
DomainSHMT
Pfam PF00464  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00260 Glycine, serine and threonine metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00670 One carbon pool by folate
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01523 Antifolate resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1904482 cellular response to tetrahydrofolate
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0019264 glycine biosynthetic process from serine
Biological Process GO:0006544 glycine metabolic process
Biological Process GO:0006564 L-serine biosynthetic process
Biological Process GO:0006565 L-serine catabolic process
Biological Process GO:0006563 L-serine metabolic process
Biological Process GO:0006730 one-carbon metabolic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0070536 protein K63-linked deubiquitination
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0009113 purine nucleobase biosynthetic process
Biological Process GO:1903715 regulation of aerobic respiration
Biological Process GO:0070129 regulation of mitochondrial translation
Biological Process GO:0002082 regulation of oxidative phosphorylation
Biological Process GO:0034340 response to type I interferon
Biological Process GO:0035999 tetrahydrofolate interconversion
Biological Process GO:0046653 tetrahydrofolate metabolic process
molecular function GO:0016597 amino acid binding
molecular function GO:0003682 chromatin binding
molecular function GO:0050897 cobalt ion binding
molecular function GO:0004372 glycine hydroxymethyltransferase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0008732 L-allo-threonine aldolase activity
molecular function GO:0048027 mRNA 5'-UTR binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0070905 serine binding
molecular function GO:0000900 translation repressor activity, mRNA regulatory element binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0070552 BRISC complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005758 mitochondrial intermembrane space
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0042645 mitochondrial nucleoid
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196757 Metabolism of folate and pterines
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017185 BXGD001104 Gastrointestinal Neoplasms Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1608408 BXGD013434 Malignant transformation
C1709246 BXGD013622 Non-Neoplastic Disorder Pathological Conditions, Signs and Symptoms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722419 BXGD023802 Extrapulmonary Small Cell Carcinoma Neoplasms
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0043088 Pyridoxal Phosphate 247.02
BXGC0049447 acetate 59.01
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein