Showing entry for Keratin, type II cytoskeletal 2 epidermal


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009878
Protein NameKeratin, type II cytoskeletal 2 epidermal
Uniport IdP35908
GeneKRT2
Gene Id3849
DomainFilament; Keratin_2_head
Pfam PF00038   PF16208  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070268 cornification
Biological Process GO:0008544 epidermis development
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0031424 keratinization
Biological Process GO:0032980 keratinocyte activation
Biological Process GO:0003334 keratinocyte development
Biological Process GO:0051546 keratinocyte migration
Biological Process GO:0043616 keratinocyte proliferation
Biological Process GO:0018149 peptide cross-linking
Biological Process GO:0045684 positive regulation of epidermis development
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0005200 structural constituent of cytoskeleton
molecular function GO:0030280 structural constituent of skin epidermis
cellular component GO:0001533 cornified envelope
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0005882 intermediate filament
cellular component GO:0045095 keratin filament
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000887 BXGD000017 Acantholysis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0079153 BXGD003064 Hyperkeratosis, Epidermolytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0423757 BXGD008504 Thin skin
C0432306 BXGD008770 Ichthyosis Bullosa of Siemens Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C1274214 BXGD012024 Autosomal dominant ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1838440 BXGD014315 ICHTHYOSIS EXFOLIATIVA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2132198 BXGD016930 Abnormal blistering of the skin
C3665704 BXGD019299 Congenital reticular ichthyosiform erythroderma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein