Showing entry for Homeobox protein Nkx-2.5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010319
Protein NameHomeobox protein Nkx-2.5
Uniport IdP42582
GeneNkx2-5
Gene Id18091
DomainHomeodomain
Pfam PF00046  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007512 adult heart development
Biological Process GO:0003278 apoptotic process involved in heart morphogenesis
Biological Process GO:0055014 atrial cardiac muscle cell development
Biological Process GO:0060413 atrial septum morphogenesis
Biological Process GO:0060928 atrioventricular node cell development
Biological Process GO:0060929 atrioventricular node cell fate commitment
Biological Process GO:0003162 atrioventricular node development
Biological Process GO:0003166 bundle of His development
Biological Process GO:0003161 cardiac conduction system development
Biological Process GO:0055007 cardiac muscle cell differentiation
Biological Process GO:0060038 cardiac muscle cell proliferation
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0048738 cardiac muscle tissue development
Biological Process GO:0055008 cardiac muscle tissue morphogenesis
Biological Process GO:0003211 cardiac ventricle formation
Biological Process GO:0003208 cardiac ventricle morphogenesis
Biological Process GO:0072358 cardiovascular system development
Biological Process GO:0030154 cell differentiation
Biological Process GO:0035050 embryonic heart tube development
Biological Process GO:0060971 embryonic heart tube left/right pattern formation
Biological Process GO:0007492 endoderm development
Biological Process GO:0060047 heart contraction
Biological Process GO:0007507 heart development
Biological Process GO:0001947 heart looping
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0060347 heart trabecula formation
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0010667 negative regulation of cardiac muscle cell apoptotic process
Biological Process GO:0010832 negative regulation of myotube differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0003148 outflow tract septum morphogenesis
Biological Process GO:0060037 pharyngeal system development
Biological Process GO:0051891 positive regulation of cardioblast differentiation
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045823 positive regulation of heart contraction
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0010765 positive regulation of sodium ion transport
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
Biological Process GO:0010735 positive regulation of transcription via serum response element binding
Biological Process GO:0003342 proepicardium development
Biological Process GO:0003350 pulmonary myocardium development
Biological Process GO:0003168 Purkinje myocyte differentiation
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0060043 regulation of cardiac muscle cell proliferation
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0003221 right ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0003285 septum secundum development
Biological Process GO:0048536 spleen development
Biological Process GO:0030878 thyroid gland development
Biological Process GO:0043586 tongue development
Biological Process GO:0001570 vasculogenesis
Biological Process GO:0055015 ventricular cardiac muscle cell development
Biological Process GO:0055005 ventricular cardiac myofibril assembly
Biological Process GO:0060412 ventricular septum morphogenesis
Biological Process GO:0003222 ventricular trabecula myocardium morphogenesis
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0042802 identical protein binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0032993 protein-DNA complex
cellular component GO:0090575 RNA polymerase II transcription regulator complex
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002071 Apigenin 270.24
BXGC0006635 Luteolin 286.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein