protein

Showing entry for GMP synthase [glutamine-hydrolyzing]

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT010763
Protein Name	GMP synthase [glutamine-hydrolyzing]
Uniport Id	P49915
Gene	GMPS
Gene Id	8833
Domain	GATase; GMP_synt_C; NAD_synthase
Pfam	PF00117 PF00958 PF02540
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.4 Nucleotide metabolism	hsa00230	Purine metabolism
1. Metabolism	1.11 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006541	glutamine metabolic process
Biological Process	GO:0006177	GMP biosynthetic process
Biological Process	GO:0009113	purine nucleobase biosynthetic process
Biological Process	GO:0009168	purine ribonucleoside monophosphate biosynthetic process
molecular function	GO:0005524	ATP binding
molecular function	GO:0003922	GMP synthase (glutamine-hydrolyzing) activity
molecular function	GO:0003921	GMP synthase activity
molecular function	GO:0016462	pyrophosphatase activity
cellular component	GO:0005829	cytosol

Reactome

Pathway Id	Pathway Name
R-HSA-1430728	Metabolism
R-HSA-15869	Metabolism of nucleotides
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis
R-HSA-8956320	Nucleobase biosynthesis

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0011853	BXGD000752	Diabetes Mellitus, Experimental	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0023903	BXGD001720	Liver neoplasms	Digestive System Diseases; Neoplasms
C0041228	BXGD002900	African Trypanosomiasis	Infections
C0041296	BXGD002903	Tuberculosis	Infections
C0206139	BXGD004159	Lichen Planus, Oral	Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0206624	BXGD004190	Hepatoblastoma	Neoplasms
C0220630	BXGD004302	Adult Liver Carcinoma	Digestive System Diseases; Neoplasms
C0279000	BXGD006622	Liver and Intrahepatic Biliary Tract Carcinoma	Digestive System Diseases; Neoplasms
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2676033	BXGD017322	Hepatoblastoma Caused By Somatic Mutation	Digestive System Diseases; Neoplasms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0006162	L-Glutamic acid		147.13
BXGC0017558	2,3,4,5-Tetrabromo-6-(3,5-Dibromo-2-Hydroxyphenoxy)Phenol		669.53
BXGC0019688	2,3,4-Tribromo-6-(2,4-Dibromophenoxy)Phenol		575.62
BXGC0040206	3,4,5-Tribromo-2-(2,4-Dibromophenoxy)Phenol		575.62
BXGC0043657	2,3,5-Tribromo-6-(3,5-Dibromo-2-Hydroxyphenoxy)Phenol		591.62
BXGC0051920	3,5-Dibromo-2-(2,4-Dibromophenoxy)Phenol		497.71

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}