Showing entry for DNA topoisomerase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012779
Protein NameDNA topoisomerase 1
Uniport IdQ04750
GeneTop1
Gene Id21969
DomainTopoisom_I; Topoisom_I_N; Topo_C_assoc
Pfam PF14370   PF01028   PF02919  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006260 DNA replication
Biological Process GO:0006265 DNA topological change
Biological Process GO:0040016 embryonic cleavage
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0042493 response to drug
Biological Process GO:0009303 rRNA transcription
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0003697 single-stranded DNA binding
molecular function GO:0097100 supercoiled DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0001651 dense fibrillar component
cellular component GO:0001650 fibrillar center
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000932 P-body
cellular component GO:0043204 perikaryon
cellular component GO:0032993 protein-DNA complex
cellular component GO:0031298 replication fork protection complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0016470 Camptothecin 348.11
BXGC0032970 4-Hydroxysaprothoquinone 314.19
BXGC0034783 Doxorubicin 543.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein