Showing entry for Camptothecin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0016470
Compound NameCamptothecin
Structure
FormulaC20H16N2O4
InchiKeyVSJKWCGYPAHWDS-FQEVSTJZSA-N
SMILESCC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccccc4cc3Cn1c2=O
InchiInChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
IUPAC
Molecular Weight348.11
Pubchem Id24360
Chembl IdCHEMBL65
Targets of Information Source
DrugBank DB04690
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 experimental -
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50008923
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 reviewed Kinase EIF2AK3 - - - >55700
reviewed BXGT007923 Cystic fibrosis transmembrane conductance regulator reviewed Ion channel CFTR - - - >50000
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 20000 - -
reviewed BXGT007697 DNA topoisomerase 2-alpha reviewed TOP2A - >3.50e+5 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 127000 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 679 - -
reviewed BXGT012779 DNA topoisomerase 1 reviewed Top1 - 40000 - -
reviewed BXGT012779 DNA topoisomerase 1 reviewed Top1 - 12000 - -
reviewed BXGT017229 DNA topoisomerase 1 reviewed TOP1 - 27000 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 4000 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 17000 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 9000 - -
reviewed BXGT007697 DNA topoisomerase 2-alpha reviewed TOP2A - >300000 - -
reviewed BXGT011385 Ribonuclease pancreatic reviewed RNASE1 - >300000 - -
reviewed BXGT005601 Deoxyribonuclease-1 reviewed DNASE1 - >300000 - -
reviewed BXGT004926 Deoxyribonuclease-2-alpha reviewed DNASE2 - >300000 - -
reviewed BXGT005709 DNA ligase reviewed 30 - >300000 - -
reviewed BXGT008929 Type-2 restriction enzyme BamHI reviewed bamHIR - >300000 - -
reviewed BXGT005604 Type-2 restriction enzyme EcoRI reviewed ecoRIR - >300000 - -
reviewed BXGT010415 Type-2 restriction enzyme HindIII reviewed hindIIIR - >300000 - -
reviewed BXGT005602 Type-2 restriction enzyme PstI reviewed pstIR - >300000 - -
reviewed BXGT004690 Type-2 restriction enzyme ScaI reviewed scaIR - >300000 - -
reviewed BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT - >300000 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - - - 350
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 700 - -
reviewed BXGT009813 Somatostatin receptor type 5 reviewed G-protein coupled receptor SSTR5 - 2.2 - -
reviewed BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 reviewed HNRNPA1 - - 82.7 -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 680 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 300 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 2200 - -
reviewed BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 - - - 2.1
CHEMBL CHEMBL65
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 460 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 6309 nM
Q9NJG8 BXGT021134 DNA topoisomerase I unreviewed - TOP1 Inhibition '=' 65 %
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 125 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Change '=' 3 %
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency - 22387 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 44 %
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 1122 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 47 %
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 107 %
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '>' 100000 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency - 35481 nM
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 680 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 3162 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Stimulation '=' 8 -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' 90 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 23 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 78 %
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 3548 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P02787 BXGT005962 Serotransferrin reviewed Enzyme TF KSV '=' 2 10'4L/mol
P02769 BXGT005956 Serum albumin reviewed - ALB KSV '=' 3 10'4L/mol
A0JN73 BXGT000827 DNA topoisomerase unreviewed - TOP3A Inhibition - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 37 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 70 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 79 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 37 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 14125 nM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P23940 BXGT008929 Type-2 restriction enzyme BamHI reviewed - bamHIR IC50 '>' 300000 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 56 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 70 %
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 2511 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 25 %
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 79 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 398 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition - - -
P02768 BXGT005955 Serum albumin reviewed Transporter ALB K '=' 4700 1/Maa
P61823 BXGT011385 Ribonuclease pancreatic reviewed - RNASE1 IC50 '>' 300000 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 1584 nM
Q653V4 BXGT016139 Os06g0676700 protein unreviewed - Os06g0676700 Potency '=' 15848 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 251 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 CC50 '=' 820 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 26 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Change '=' 6 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Change '=' 12 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Change '=' 9 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 700 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 3548 nM
Q9HBX9 BXGT020523 Relaxin receptor 1 reviewed G-protein coupled receptor RXFP1 Potency '=' 12589 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 5 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 5 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 39810 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 2818 nM
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse IC50 '>' 200 ug.mL-1
P00639 BXGT005601 Deoxyribonuclease-1 reviewed - DNASE1 IC50 '>' 300000 nM
P00642 BXGT005604 Type-2 restriction enzyme EcoRI reviewed - ecoRIR IC50 '>' 300000 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 7943 nM
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 K app '=' 0 1/min
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 REC '=' 0 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' 0 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Fluorescence intensity '=' 1 -
Q9NJG8 BXGT021134 DNA topoisomerase I unreviewed - TOP1 Inhibition '=' 55 %
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 13371 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' 0 -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 11220 nM
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Activity '=' 1 -
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 reviewed Kinase EIF2AK3 EC50 '>' 55700 nM
O62855 BXGT004926 Deoxyribonuclease-2-alpha reviewed - DNASE2 IC50 '>' 300000 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Relaxed DNA '=' 64 %
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 4466 nM
O52691 BXGT004690 Type-2 restriction enzyme ScaI reviewed - scaIR IC50 '>' 300000 nM
P43870 BXGT010415 Type-2 restriction enzyme HindIII reviewed - hindIIIR IC50 '>' 300000 nM
Q04750 BXGT012779 DNA topoisomerase 1 reviewed - Top1 IC50 '=' 12000 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 28 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency - 14125 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 35481 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 125 nM
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
Q9NJG8 BXGT021134 DNA topoisomerase I unreviewed - TOP1 Inhibition '=' 39 %
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P00970 BXGT005709 DNA ligase reviewed - 30 IC50 '>' 300000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 4000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 9000 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 17782 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Cleavage '=' 325 %
P09651 BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 reviewed - HNRNPA1 Inhibition - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Change '=' 7 %
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Log K' '=' 0 -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 4466 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 679 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Activity - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B Inhibition - - -
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 316 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P09651 BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 reviewed - HNRNPA1 Kd '=' 82 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 68 %
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 89125 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 FC '=' 1 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 EC50 '=' 350 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 '>' 300000 nM
P00640 BXGT005602 Type-2 restriction enzyme PstI reviewed - pstIR IC50 '>' 300000 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 50118 nM
P32745 BXGT009663 Somatostatin receptor type 3 reviewed G-protein coupled receptor SSTR3 IC50 '=' 2 nM
P30872 BXGT009474 Somatostatin receptor type 1 reviewed G-protein coupled receptor SSTR1 IC50 '=' 2 nM
P31391 BXGT009535 Somatostatin receptor type 4 reviewed G-protein coupled receptor SSTR4 IC50 '=' 2 nM
P30874 BXGT009475 Somatostatin receptor type 2 reviewed G-protein coupled receptor SSTR2 IC50 '=' 2 nM
P35346 BXGT009813 Somatostatin receptor type 5 reviewed G-protein coupled receptor SSTR5 IC50 '=' 2 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
A0JN73 BXGT000827 DNA topoisomerase unreviewed - TOP3A Activity - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 77 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 366 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 30 %
A0JN73 BXGT000827 DNA topoisomerase unreviewed - TOP3A IC50 '=' 17000 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 3162 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 4750 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 75 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 10000 nM
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 EC50 '=' 2 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 3981 nM
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 239 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 17000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 79 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 23 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 10000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Effect '=' 2 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 25 %
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 2238 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 1995 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 4950 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 40 %
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 3162 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency - 8912 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 68 %
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
Q95Z89 BXGT019591 DNA topoisomerase type IB small subunit unreviewed - Top1B Inhibition - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 64 %
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 100000 nM
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 32 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 27 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 22387 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 316 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 20000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 64 %
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 44668 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A FC - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 3548 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 85 %
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 46109 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 4609 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 69 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 3162 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 4466 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Ratio '=' 0 -
P09651 BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 reviewed - HNRNPA1 Bmax '=' 67 pg/mm2
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 10 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 95 %
Q95Z89 BXGT019591 DNA topoisomerase type IB small subunit unreviewed - Top1B EC50 '=' 670 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 46 %
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 5323 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 6309 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 86 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 3750 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 66 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 3981 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 100 uM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 46 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 31622 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
Q04750 BXGT012779 DNA topoisomerase 1 reviewed - Top1 MIC '=' 86 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Fluorescence intensity '=' 2 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 127000 nM
Q04750 BXGT012779 DNA topoisomerase 1 reviewed - Top1 IC50 '=' 40000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 DNA cleavage - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 50 %
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 1778 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Effect '=' 96 %
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 28183 nM
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 4 %
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 22387 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' 84 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 39810 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 100 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 41 %
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 199 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 31622 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 1995 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 104 nM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Fluorescence intensity '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 89 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 231 nM
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Activity '=' 2 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 35 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 39 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 CC50 '=' 800 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 79 %
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 REC '=' 1 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 - - -
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 2511 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 74 %
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 2908 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 '=' 970 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 17782 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 7307 nM
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 9 %
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 43 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC10 '=' 0 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 20 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 58 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 40 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 59 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 300 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 35 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 12589 nM
P02787 BXGT005962 Serotransferrin reviewed Enzyme TF Activity - - -
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 12589 nM
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 75 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' - -
P02768 BXGT005955 Serum albumin reviewed Transporter ALB K '=' 30 1/Maa
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 1000 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
Q7YR26 BXGT017229 DNA topoisomerase 1 reviewed - TOP1 IC50 '=' 27000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 67 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 52 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Effect '=' 84 %
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B MIC '>' 100000 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 19952 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 34 %
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 2511 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 25 nM
Q2HPH0 BXGT014088 Topoisomerase I unreviewed - Activity '=' 47 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 MIC '=' 10 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Fluorescence intensity '=' 11 -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 3 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 0 %
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 7079 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 501 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 17782 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 60 %
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 79 nM
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P02769 BXGT005956 Serum albumin reviewed - ALB Kq '=' 3 10'12L/mol/s
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
Q2HPH0 BXGT014088 Topoisomerase I unreviewed - Inhibition - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '>' 95 %
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 617 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 631 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 14 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 2511 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 461 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Inhibition - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 15 nM
P02787 BXGT005962 Serotransferrin reviewed Enzyme TF KSV '=' 4 10'4L/mol
P02769 BXGT005956 Serum albumin reviewed - ALB KSV '=' 3 10'4L/mol
O95551 BXGT005384 Tyrosyl-DNA phosphodiesterase 2 reviewed - TDP2 IC50 '>' 111000 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 39810 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 IC50 - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 31 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 8912 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 84 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 26 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 58 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 19952 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 FC '=' 2 -
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 3548 nM
P42858 BXGT010341 Huntingtin reviewed - HTT Potency '=' 5623 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 71 %
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT IC50 '>' 300000 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition '=' 74 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 74 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 8912 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 27 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 316 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 63 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Inhibition - - -
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency - 17782 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 398 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 2667 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 74 %
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition '=' 40 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 26 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 0 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 69 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2059 nM
P02769 BXGT005956 Serum albumin reviewed - ALB Kq '=' 3 10'12L/mol/s
O95551 BXGT005384 Tyrosyl-DNA phosphodiesterase 2 reviewed - TDP2 IC50 '=' 0 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 36 %
Q2HPH0 BXGT014088 Topoisomerase I unreviewed - Activity '=' 49 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 45 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 65 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 33 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 135000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 2200 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 25 nM
Q2HPH0 BXGT014088 Topoisomerase I unreviewed - Inhibition '=' 58 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 19 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 17 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 FC '=' 2 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 53 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 44 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 24 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 28 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 80 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 34 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 55 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 22 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 45 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 45 %
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' 25 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 58 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity '=' 40 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 IC50 '>' 111000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 83 %
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 61 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 FC '=' 2 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 86 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 IC50 '=' 0 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition '=' 80 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 80 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 21 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 79 %
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 7400 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 23 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 74 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 73 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01422 Camptotheca acuminata Camptotheca acuminata Medicinal Plant
BXGF03033 Aristolochia triangularis Aristolochia triangularis Medicinal Plant
BXGF04453 Idesia polycarpa Idesia polycarpa Medicinal Plant
BXGF04802 Hibiscus syriacus Hibiscus syriacus Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease