Showing entry for Doxorubicin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0034783
Compound NameDoxorubicin
Structure
FormulaC27H29NO11
InchiKeyAOJJSUZBOXZQNB-TZSSRYMLSA-N
SMILESOCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](N)[C@@H]([C@@H](O2)C)O)c2c(C1)c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2OC
InchiInChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
IUPAC(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
Molecular Weight543.17
Pubchem Id31703
Chembl IdCHEMBL53463
Targets of Information Source
DrugBank DB00997
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A approved; investigational inhibitor
Q14978 BXGT013517 Nucleolar and coiled-body phosphoprotein 1 reviewed - NOLC1 approved; investigational -
PDB DM2
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P10844 BXGT007625 Botulinum neurotoxin type B reviewed botB - - - 9400 -
P31224 BXGT009517 Multidrug efflux pump subunit AcrB reviewed acrB - - - - -
P16083 BXGT008187 Ribosyldihydronicotinamide dehydrogenase [quinone] reviewed NQO2 - - - 274 -
P30626 BXGT009450 Sorcin reviewed SRI - - - - -
P01011 BXGT005715 Alpha-1-antichymotrypsin reviewed SERPINA3 Enzyme modulator - - - -
Binding DB 22984
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012424 DNA ligase A reviewed ligA - 5000 - -
reviewed BXGT005709 DNA ligase reviewed 30 - 3000 - -
reviewed BXGT006696 Heat shock protein HSP 90-alpha reviewed Chaperone HSP90AA1 - 266 - -
reviewed BXGT013335 Steroidogenic factor 1 reviewed Nuclear receptor NR5A1 - 964 - -
reviewed BXGT013335 Steroidogenic factor 1 reviewed Nuclear receptor NR5A1 - 1182 - -
reviewed BXGT011400 14-3-3 protein gamma reviewed Chaperone YWHAG - <781.25 - -
reviewed BXGT006696 Heat shock protein HSP 90-alpha reviewed Chaperone HSP90AA1 - >30000 - -
reviewed BXGT012884 DNA repair protein RAD51 homolog 1 reviewed RAD51 - 85000 - -
reviewed BXGT021373 Protein LANA1 reviewed LANA1 - - - 7690
reviewed BXGT004084 Apoptotic protease-activating factor 1 reviewed APAF1 - 21200 - -
reviewed BXGT004084 Apoptotic protease-activating factor 1 reviewed APAF1 - >100000 - -
reviewed BXGT011111 Caspase-9 reviewed Enzyme CASP9 - 34600 - -
reviewed BXGT012426 DNA primase reviewed dnaG - 9300 - -
reviewed BXGT012779 DNA topoisomerase 1 reviewed Top1 - >200000 - -
reviewed BXGT017229 DNA topoisomerase 1 reviewed TOP1 - >200000 - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - >200000 - -
reviewed BXGT007697 DNA topoisomerase 2-alpha reviewed TOP2A - 1000 - -
reviewed BXGT011385 Ribonuclease pancreatic reviewed RNASE1 - 25000 - -
reviewed BXGT005601 Deoxyribonuclease-1 reviewed DNASE1 - >200000 - -
reviewed BXGT004926 Deoxyribonuclease-2-alpha reviewed DNASE2 - >200000 - -
reviewed BXGT005709 DNA ligase reviewed 30 - >200000 - -
reviewed BXGT008929 Type-2 restriction enzyme BamHI reviewed bamHIR - >200000 - -
reviewed BXGT005604 Type-2 restriction enzyme EcoRI reviewed ecoRIR - >200000 - -
reviewed BXGT010415 Type-2 restriction enzyme HindIII reviewed hindIIIR - 96000 - -
reviewed BXGT005602 Type-2 restriction enzyme PstI reviewed pstIR - >200000 - -
reviewed BXGT004690 Type-2 restriction enzyme ScaI reviewed scaIR - 25000 - -
reviewed BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT - 73000 - -
reviewed BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed CISD1 - 80760 - -
reviewed BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed CISD1 3451 - - -
reviewed BXGT007697 DNA topoisomerase 2-alpha reviewed TOP2A - 3000 - -
reviewed BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 - - 11000000 -
reviewed BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 - 1100 - -
reviewed BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 >10000 - - -
reviewed BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 - 20000 - -
reviewed BXGT004117 Aurora kinase A reviewed Kinase AURKA - 40 - -
reviewed BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 230000 - - -
reviewed BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 - 240000 - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 38000 - - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 - 41000 - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 150000 - - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 - 160000 - -
reviewed BXGT008436 Carnitine O-palmitoyltransferase 2, mitochondrial reviewed Cpt2 - >100000 - -
reviewed BXGT009609 Carnitine O-palmitoyltransferase 1, liver isoform reviewed Cpt1a - 250000 - -
reviewed BXGT021657 7-dehydrocholesterol reductase reviewed Enzyme DHCR7 - 150 - -
reviewed BXGT021657 7-dehydrocholesterol reductase reviewed Enzyme DHCR7 - 200 - -
reviewed BXGT021657 7-dehydrocholesterol reductase reviewed Enzyme DHCR7 - 300 - -
reviewed BXGT021657 7-dehydrocholesterol reductase reviewed Enzyme DHCR7 - 10000 - -
reviewed BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 - 50000 - -
CHEMBL CHEMBL53463
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B EC50 - - -
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A EC50 - - -
O43497 BXGT004596 Voltage-dependent T-type calcium channel subunit alpha-1G reviewed Ion channel CACNA1G IC50 - - -
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 IC50 '=' 1100 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki '=' 2078 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 '=' 15336 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
O35379 BXGT004525 Multidrug resistance-associated protein 1 reviewed - Abcc1 Activity - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Activity - - -
P18886 BXGT008436 Carnitine O-palmitoyltransferase 2, mitochondrial reviewed - Cpt2 IC50 '>' 100000 nM
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 reviewed - CBR1 Km '=' 287000 nM
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT Activity '=' 14 %
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT Activity '=' 34 %
O95255 BXGT005363 Multidrug resistance-associated protein 6 reviewed Transporter ABCC6 Activity - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 26679 nM
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT IC50 '=' 73000 nM
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 reviewed - CBR1 Kcat '=' 0 /min
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A IC50 - - -
P02554 BXGT005892 Tubulin beta chain reviewed - IC50 - - -
P23940 BXGT008929 Type-2 restriction enzyme BamHI reviewed - bamHIR IC50 '>' 200000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 FC '=' 1 -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_Papp '=' 0 -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT Activity '=' 5 %
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Activity - - -
P00642 BXGT005604 Type-2 restriction enzyme EcoRI reviewed - ecoRIR IC50 '>' 200000 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 53 %
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 '=' 2485 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 0 pm/min/mg
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Activity - - -
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition '=' 0 %
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 GI50 '=' 26000 nM
P00970 BXGT005709 DNA ligase reviewed - 30 Activity - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ratio IC50 '=' 2 -
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition - - -
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 Inhibition - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Kact '=' 5 uM
Q7YR26 BXGT017229 DNA topoisomerase 1 reviewed - TOP1 IC50 '>' 200000 nM
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
Q04750 BXGT012779 DNA topoisomerase 1 reviewed - Top1 IC50 '>' 200000 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 2400 nM
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT Inhibition '<' 50 %
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 '=' 1000 nM
P43870 BXGT010415 Type-2 restriction enzyme HindIII reviewed - hindIIIR IC50 '=' 96000 nM
O88269 BXGT005267 Multidrug resistance-associated protein 6 reviewed - Abcc6 Activity - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P03905 BXGT006113 NADH-ubiquinone oxidoreductase chain 4 reviewed Enzyme MT-ND4 Activity '=' 0 units ml-1
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition '=' 72 %
P43245 BXGT010370 ATP-dependent translocase ABCB1 reviewed - Abcb1 Activity - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 12 %
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' -5 %
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 GI50 '=' 24000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 14 nm/s
P00772 BXGT005648 Chymotrypsin-like elastase family member 1 reviewed - CELA1 Inhibition - - -
P08419 BXGT006770 Chymotrypsin-like elastase family member 2A reviewed - CELA2A Inhibition - - -
A0JN73 BXGT000827 DNA topoisomerase unreviewed - TOP3A IC50 '>' 200000 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Activity - - -
P00375 BXGT005521 Dihydrofolate reductase reviewed - Dhfr Log 1/C '=' 7 -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 3000 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Inhibition '=' 30 %
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Ki '>' 10000 nM
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse IC50 '=' 52000 nM
O62855 BXGT004926 Deoxyribonuclease-2-alpha reviewed - DNASE2 IC50 '>' 200000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '>' 200000 nM
O52691 BXGT004690 Type-2 restriction enzyme ScaI reviewed - scaIR IC50 '=' 25000 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
Q9NZ45 BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed - CISD1 IC50 '=' 80760 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B Activity '=' 1 umol
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A Activity '=' 1 umol
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Ki '=' 38000 nM
Q8BW75 BXGT017924 Amine oxidase [flavin-containing] B reviewed - Maob Activity - - -
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 IC50 '=' 20000 nM
P11387 BXGT007696 DNA topoisomerase 1 reviewed Enzyme TOP1 Inhibition '=' 35 %
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Activity - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P02768 BXGT005955 Serum albumin reviewed Transporter ALB PPB '=' 62 %
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 135000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki '=' 3693 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 '=' 5147 nM
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 '=' 34464 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a Activity - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 reviewed - CBR1 Kcat '=' 0 /s
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 12589 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_ATPase activity '=' 0 -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 % maximum response '=' 0 %
P07477 BXGT006629 Trypsin-1 reviewed Enzyme PRSS1 Inhibition - - -
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Ki '=' 230000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Ki '=' 150000 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 900 nM
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 Vmax '=' 8 nmol/min
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' 49 %
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 reviewed Transcription factor EPAS1 EC50 '=' 120 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A EC50 '=' 120 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 87 %
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Activity '=' -4 -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Activity '=' -4 -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Activity '=' -4 -
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase reviewed Enzyme DHCR7 IC50 '=' 300 nM
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP IC50 '=' 300 nM
P19821 BXGT008521 DNA polymerase I, thermostable reviewed - polA Inhibition - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase reviewed Enzyme DHCR7 IC50 '=' 150 nM
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP IC50 '=' 150 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '=' 31913 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
Q9NZ45 BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed - CISD1 Ki '=' 3451 nM
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Activity - - -
P00375 BXGT005521 Dihydrofolate reductase reviewed - Dhfr Log 1/C '=' 7 -
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 reviewed - CBR1 Km '=' 167000 nM
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Inhibition '=' 7 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
Q5T3U5 BXGT015846 Multidrug resistance-associated protein 7 reviewed Transporter ABCC10 Activity '=' 18 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ratio IC50 '>' 5 -
P10844 BXGT007625 Botulinum neurotoxin type B reviewed - botB Activity '=' 9 uM
P32198 BXGT009609 Carnitine O-palmitoyltransferase 1, liver isoform reviewed - Cpt1a IC50 '=' 250000 nM
O15297 BXGT004149 Protein phosphatase 1D reviewed Enzyme PPM1D Inhibition - - -
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 reviewed Kinase KDR IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 '=' 13590 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P00970 BXGT005709 DNA ligase reviewed - 30 IC50 '>' 200000 nM
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform reviewed Kinase PIK3CA EC50 - - -
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha reviewed Kinase PIK3R1 EC50 - - -
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 0 pm/min/mg
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Inhibition - - -
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase reviewed Enzyme DHCR7 IC50 '=' 200 nM
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP IC50 '=' 200 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P00640 BXGT005602 Type-2 restriction enzyme PstI reviewed - pstIR IC50 '>' 200000 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 9 nm/s
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 '=' 880 nM
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 IC50 '=' 41000 nM
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 '=' 12192 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Kd - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
Q96QA9 BXGT019717 Multidrug resistance associated protein unreviewed - MRP3 Activity '=' 80 %
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity '=' 72 %
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki '=' 15666 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 reviewed Enzyme AKR1A1 Km '=' 247000 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 reviewed Enzyme AKR1A1 Activity '=' 11 nmol/min
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ki '=' 8500 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 IC50 '=' 160000 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P61823 BXGT011385 Ribonuclease pancreatic reviewed - RNASE1 IC50 '=' 25000 nM
P00639 BXGT005601 Deoxyribonuclease-1 reviewed - DNASE1 IC50 '>' 200000 nM
O14965 BXGT004117 Aurora kinase A reviewed Kinase AURKA IC50 '=' 40 nM
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 '=' 12468 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
Q7TMS5 BXGT017145 ATP-binding cassette sub-family G member 2 reviewed - Abcg2 Activity - - -
P11388 BXGT007697 DNA topoisomerase 2-alpha reviewed - TOP2A IC50 '=' 3000 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 26 %
P00374 BXGT005520 Dihydrofolate reductase reviewed Enzyme DHFR Inhibition - - -
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 19000 nM
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 IC50 '=' 50000 nM
Q6PSM0 BXGT016483 Multidrug resistance protein 1a unreviewed - Mdr1a Activity - - -
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 reviewed - CBR1 Kcat '=' 0 /s
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 IC50 - - -
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 IC50 - - -
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 IC50 - - -
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 IC50 - - -
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 IC50 - - -
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 IC50 - - -
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 IC50 - - -
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 IC50 - - -
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 IC50 - - -
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 IC50 - - -
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Kd '=' 11000000 nM
P04191 BXGT006170 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 reviewed - ATP2A1 Kd - - -
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 reviewed Enzyme AKR1A1 Kcat '=' 0 /min
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 IC50 '=' 240000 nM
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 reviewed - CBR1 Km '=' 90000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B IC50 '=' 3500 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
P00374 BXGT005520 Dihydrofolate reductase reviewed Enzyme DHFR IC50 - - -
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform reviewed Kinase PIK3CA EC50 - - -
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 IC50 - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF05739 Ixora coccinea Ixora coccinea Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease