Showing entry for DNA oxidative demethylase ALKBH2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016425
Protein NameDNA oxidative demethylase ALKBH2
Uniport IdQ6NS38
GeneALKBH2
Gene Id121642
Domain2OG-FeII_Oxy_2
Pfam PF13532  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006307 DNA dealkylation involved in DNA repair
Biological Process GO:0080111 DNA demethylation
Biological Process GO:0070989 oxidative demethylation
Biological Process GO:0035511 oxidative DNA demethylation
molecular function GO:0103053 1-ethyladenine demethylase activity
molecular function GO:0051747 cytosine C-5 DNA demethylase activity
molecular function GO:0043734 DNA-N1-methyladenine dioxygenase activity
molecular function GO:0008198 ferrous iron binding
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-112122 ALKBH2 mediated reversal of alkylation damage
R-HSA-73894 DNA Repair
R-HSA-73942 DNA Damage Reversal
R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000764 L-Ascorbic acid 176.12
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0002588 Magnesium 24.31
BXGC0006172 1-Propanethiol 76.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein