Showing entry for 2-Oxopentanedioic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0002485
Compound Name2-Oxopentanedioic acid
Structure
FormulaC5H6O5
InchiKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILESOC(=O)CCC(=O)C(O)=O
InchiInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
IUPAC2-oxopentanedioic acid
Molecular Weight146.1
Pubchem Id51
Chembl IdCHEMBL1686
Targets of Information Source
DrugBank DB08845
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P00509 BXGT005562 Aspartate aminotransferase reviewed - aspC experimental; investigational; nutraceutical -
PDB AKG
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00509 BXGT005562 Aspartate aminotransferase reviewed aspC - - - - -
P08200 BXGT006747 Isocitrate dehydrogenase [NADP] reviewed icd - - - - -
Q05581 BXGT012824 Clavaminate synthase 1 reviewed cs1 - - - - -
P18548 BXGT008413 Deacetoxycephalosporin C synthase reviewed cefE - - - - -
Q05755 BXGT012833 Glutamate synthase [NADPH] large chain reviewed gltB - - - - -
Q96323 BXGT019598 Leucoanthocyanidin dioxygenase reviewed LDOX - - - - -
P37610 BXGT009999 Alpha-ketoglutarate-dependent taurine dioxygenase reviewed tauD - - - - -
Q9NWT6 BXGT021234 Hypoxia-inducible factor 1-alpha inhibitor reviewed HIF1AN - - - - -
P00366 BXGT005516 Glutamate dehydrogenase 1, mitochondrial reviewed GLUD1 - - - - -
P55038 BXGT011098 Ferredoxin-dependent glutamate synthase 2 reviewed gltS - - - - -
Q8ZNF3 BXGT019219 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase reviewed arnB - - - - -
Q9XB59 BXGT022164 (5R)-carbapenem-3-carboxylate synthase reviewed carC - - - - -
Q9WWU5 BXGT021953 Alpha-ketoglutarate-dependent sulfate ester dioxygenase reviewed atsK - - - - -
P0A9T0 BXGT007200 D-3-phosphoglycerate dehydrogenase reviewed serA - - - - -
O14832 BXGT004104 Phytanoyl-CoA dioxygenase, peroxisomal reviewed PHYH - - - - -
P9WQ77 BXGT012492 Probable L-lysine-epsilon aminotransferase reviewed lat - - - - -
Q9RBY6 BXGT021441 Syringomycin biosynthesis enzyme 2 unreviewed syrB2 - - - - -
P05050 BXGT006303 Alpha-ketoglutarate-dependent dioxygenase AlkB reviewed alkB - - - - -
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed KDM4A - - - - -
Q96Q83 BXGT019715 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 reviewed ALKBH3 - - - - -
Q60381 BXGT015981 Uncharacterized nitrogen regulatory PII-like protein MJ0059 reviewed MJ0059 - - - - -
P21954 BXGT008712 Isocitrate dehydrogenase [NADP], mitochondrial reviewed IDP1 - - - - -
Q82IZ1 BXGT017401 1-deoxypentalenic acid 11-beta-hydroxylase reviewed ptlH - - - - -
P29283 BXGT009330 Global nitrogen regulator reviewed ntcA - - - - -
O15054 BXGT004121 Lysine-specific demethylase 6B reviewed KDM6B Epigenetic regulator - - - -
P0A3F4 BXGT007012 Nitrogen regulatory protein P-II reviewed glnB - - - - -
A3EYF7 BXGT001152 Beta-transaminase unreviewed - - - - -
Q9Y2K7 BXGT022239 Lysine-specific demethylase 2A reviewed KDM2A - - - - -
O87198 BXGT005257 Homocitrate synthase reviewed lys20 - - - - -
A2RUC4 BXGT001097 tRNA wybutosine-synthesizing protein 5 reviewed TYW5 - - - - -
O57946 BXGT004769 Uncharacterized protein unreviewed PH0207 - - - - -
Q9A9H3 BXGT020048 GDP-perosamine synthase reviewed per - - - - -
Q6NS38 BXGT016425 DNA oxidative demethylase ALKBH2 reviewed ALKBH2 - - - - -
Q8N5Z0 BXGT018521 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial reviewed AADAT Enzyme - - - -
D0VX22 BXGT002770 CytC3 unreviewed cytC3 - - - - -
B1B4V9 BXGT001876 Putative pyridoxamine 5-phosphate-dependent dehydrase unreviewed wbdK - - - - -
P17109 BXGT008283 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase reviewed menD - - - 75 -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed IDH1 - - - - -
Q9Y823 BXGT022352 Homocitrate synthase, mitochondrial reviewed lys4 - - - - -
Q9UPP1 BXGT021800 Histone lysine demethylase PHF8 reviewed PHF8 - - - - -
P40032 BXGT010156 Prolyl 3,4-dihydroxylase TPA1 reviewed TPA1 - - - - -
Q6ZMT4 BXGT016629 Lysine-specific demethylase 7A reviewed KDM7A - - - - -
P0A4U6 BXGT007038 Global nitrogen regulator reviewed ntcA - - - - -
Q6NYC1 BXGT016436 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 reviewed JMJD6 Receptor - - - -
P70731 BXGT011682 Nitrogen regulatory protein P-II 1 unreviewed glnZ - - - - -
Q6DNF2 BXGT016252 CurA unreviewed curA - - - - -
Q72KX8 BXGT016753 Lipopolysaccaride biosynthesis protein wbpB unreviewed wbpB - - - - -
Q5SRE7 BXGT015840 Phytanoyl-CoA dioxygenase domain-containing protein 1 reviewed PHYHD1 - - - - -
A0A0H3LT39 BXGT000469 Putative mandelate racemase unreviewed BB4687 - - - - -
P39956 BXGT010151 DNA damage-responsive transcriptional repressor RPH1 reviewed RPH1 - - - - -
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed EGLN1 - - - - -
Q9GYI0 BXGT020420 Lysine-specific demethylase 7 homolog reviewed jmjd-1.2 - - - - -
Q2G1L5 BXGT014048 Uncharacterized protein unreviewed SAOUHSC_00107 - - - - -
D1BN29 BXGT002793 Aminotransferase class I and II unreviewed Vpar_1105 - - - - -
Q13PB7 BXGT013421 Uncharacterized protein unreviewed Bxe_B1897 - - - - -
O28524 BXGT004313 Nitrogen regulatory protein P-II (GlnB-3) unreviewed AF_1750 - - - - -
Q96BT7 BXGT019628 Alkylated DNA repair protein alkB homolog 8 reviewed ALKBH8 - - - - -
Q8N371 BXGT018504 Bifunctional peptidase and arginyl-hydroxylase JMJD5 reviewed KDM8 - - - - -
Q88RA3 BXGT017731 Alpha-ketoglutarate-dependent sulfonate dioxygenase reviewed tauD - - - - -
Q0B2N4 BXGT013059 Uncharacterized protein unreviewed Bamb_6045 - - - - -
O14607 BXGT004075 Histone demethylase UTY reviewed UTY Transcription factor - - - -
Q8IUF8 BXGT018334 Ribosomal oxygenase 2 reviewed RIOX2 - - - - -
P47016 BXGT010559 Deaminated glutathione amidase reviewed NIT2 - - - - -
Q6B0I6 BXGT016211 Lysine-specific demethylase 4D reviewed KDM4D Epigenetic regulator - - - -
Q53WJ1 BXGT015034 Lysine-specific demethylase JMJ703 reviewed JMJ703 - - - - -
P30615 BXGT009448 Pyruvate kinase 1 reviewed PYK1 - - - - -
P27431 BXGT009182 50S ribosomal protein L16 3-hydroxylase reviewed roxA - - - - -
G9MBV2 BXGT003568 Alpha-Ketoglutarate-dependent L-arginine hydroxylase unreviewed vioC - - - - -
A0A0H3K9Y6 BXGT000447 Ornithine cyclodeaminase unreviewed sbnB - - - - -
G8GV69 BXGT003554 Dioxygenase easH reviewed easH - - - - -
Q08BA6 BXGT013017 RNA demethylase ALKBH5 reviewed alkbh5 - - - - -
Q6P6C2 BXGT016455 RNA demethylase ALKBH5 reviewed ALKBH5 - - - - -
Q6P6C2 BXGT016455 RNA demethylase ALKBH5 reviewed ALKBH5 - - 9000 - -
Q989T9 BXGT019893 L-proline cis-4-hydroxylase reviewed mlr6283 - - - - -
Q1GNW5 BXGT013780 Ectoine dioxygenase reviewed ectD - - - - -
Q9BT30 BXGT020124 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial reviewed ALKBH7 - - - - -
P0C872 BXGT007451 Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7 reviewed Jmjd7 - - - - -
P59997 BXGT011282 Lysine-specific demethylase 2A reviewed Kdm2a - - - - -
A8JI83 BXGT001706 Nitrogen regulatory protein PII unreviewed GLB1 - - 1180000 - -
A0A0M3KL01 BXGT000562 EvdO2 unreviewed evdO2 - - - - -
Q2MFS1 BXGT014135 Putative oxidase/hydroxylase unreviewed hygX - - - - -
Q2SZ78 BXGT014193 Glutamate dehydrogenase unreviewed BTH_I1224 - - - - -
Q4WAW9 BXGT014912 Verruculogen synthase reviewed ftmOx1 - - - - -
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO reviewed FTO - - - - -
P83310 BXGT022963 (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase (RdpA) reviewed rdpA - - - - -
Q7RYZ9 BXGT017092 Thymine dioxygenase unreviewed NCU06416 - - - 34400 -
Q84406 BXGT017537 Prolyl 4-hydroxylase unreviewed A085R - - - 681000 -
D2W6T1 BXGT002858 Tet-like dioxygenase 1 reviewed TET1 - - - - -
Q1XGK3 BXGT013865 4-oxalocrotonate decarboxylase NahK unreviewed nahK - - - - -
Q5AR53 BXGT015291 Iron/alpha-ketoglutarate-dependent dioxygenase asqJ reviewed asqJ - - - - -
A0A0A7GJ30 BXGT000112 Branched-chain-amino-acid aminotransferase unreviewed ilvE - - - - -
P29375 BXGT009338 Lysine-specific demethylase 5A reviewed KDM5A - - - 79000 -
Q9RN60 BXGT021475 SnoK unreviewed snoK - - - - -
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B reviewed KDM5B Epigenetic regulator - - - -
Q81LZ8 BXGT017348 Prolyl 4-hydroxylase, alpha subunit domain protein unreviewed GBAA_4459 - - - 1100 -
Q8NTR2 BXGT018612 Aspartate transaminase reviewed Cgl0240 - - - - -
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial reviewed IDH2 - - - - -
Q81LZ8 BXGT017348 Prolyl 4-hydroxylase, alpha subunit domain protein unreviewed GBAA_4459 - - - - -
P31026 BXGT009501 NADP-specific glutamate dehydrogenase reviewed gdh - - - - -
A0A067YX61 BXGT000053 WelO5 unreviewed - - - - -
P29375 BXGT009338 Lysine-specific demethylase 5A reviewed KDM5A - - - - -
A0A1L1QK38 BXGT023193 Alpha-ketoglutarate-dependent non-heme iron oxygenase EasH unreviewed - - - - -
P32021 BXGT009596 2-oxoglutarate-dependent ethylene/succinate-forming enzyme reviewed efe - - - - -
A0A0E3URV8 BXGT000171 Leucine hydroxylase unreviewed griE - - - - -
P0C870 BXGT007450 Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 reviewed JMJD7 - - - - -
D4N500 BXGT002934 Thebaine 6-O-demethylase reviewed T6ODM - - - - -
A8I3W3 BXGT001692 4-hydroxy-tetrahydrodipicolinate synthase unreviewed DPS1 - - - - -
Q9GRZ3 BXGT020414 Lysine-specific demethylase 9 reviewed dpy-21 - - - - -
Q9SIE1 BXGT021588 Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase reviewed PAT - - - - -
Q10BI6 BXGT013211 Oxidoreductase, 2OG-Fe oxygenase family protein, putative, expressed unreviewed LOC_Os03g60190 - - - - -
B6V7E4 BXGT002227 Glutamate dehydrogenase unreviewed - - - - -
P73862 BXGT011728 Rubisco operon transcriptional regulator unreviewed rbcR - - - - -
B3DUR4 BXGT002033 Uncharacterized protein unreviewed Minf_1012 - - - - -
Q5AR34 BXGT015290 Multifunctional dioxygenase ausE reviewed ausE - - - - -
A0A1E1FFL0 BXGT000723 PrhA reviewed prhA - - - - -
P96847 BXGT012189 Aminotransferase reviewed aspB - - - - -
Q9UT12 BXGT023562 Uncharacterized protein P8A3.02c reviewed SPAP8A3.02c - - - - -
A0A097ZPD5 BXGT000101 Dioxygenase andA reviewed andA - - - - -
Q387G0 BXGT023725 Isocitrate dehydrogenase [NADP] unreviewed Tb11.03.0230 - - - - -
Q6WZB0 BXGT016602 Alpha-ketoglutarate-dependent L-arginine hydroxylase reviewed vioC - - - - -
Q8KSC8 BXGT018452 (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase reviewed rdpA - - - - -
J3BZS6 BXGT003731 L-lysine 4-hydroxylase reviewed PMI10_03368 - - - - -
C7QJ42 BXGT002605 L-lysine 3-hydroxylase reviewed Caci_0231 - - - - -
O60568 BXGT004885 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 reviewed PLOD3 Enzyme - - - -
Q9I0L4 BXGT020690 Isocitrate dehydrogenase [NADP] unreviewed idh - - - - -
Q6NYC1 BXGT016436 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 reviewed JMJD6 Receptor - - 3500 -
A0A075X7F9 BXGT024075 Oxidoreductase unreviewed welO15 - - - - -
Q13686 BXGT024292 Nucleic acid dioxygenase ALKBH1 reviewed ALKBH1 - - - - -
F4KIX0 BXGT024363 Transcription factor jumonji (Jmj) family protein / zinc finger (C5HC2 type) family protein unreviewed MQD22.4 - - - - -
Q4J989 BXGT024698 Homocitrate synthase reviewed Saci_1304 - - - - -
Q8S0S6 BXGT024701 Gibberellin 2-beta-dioxygenase 3 reviewed GA2OX3 - - - - -
Q01IX6 BXGT024703 2-oxoglutarate-dependent dioxygenase DAO reviewed DAO - - - - -
A0L8G4 BXGT024902 Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein unreviewed Mmc1_1749 - - - - -
G8XHD5 BXGT024960 L-lysine 4-chlorinase reviewed besD - - - - -
A0A4V8H042 BXGT024983 Gamma-butyrobetaine hydroxylase unreviewed - - - - -
P9WK11 BXGT012352 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase reviewed menD - - - - -
Q9HUX5 BXGT025197 Pseudopaline synthase reviewed cntM - - - - -
Q79FW0 BXGT025285 Probable amino acid aminotransferase unreviewed Rv0812 - - - - -
Q6L732 BXGT025506 Kanamycin B dioxygenase reviewed kanJ - - - - -
Q6EZB3 BXGT025672 Hyoscyamine 6 beta-hydroxylase unreviewed H6H - - - - -
Q43314 BXGT026001 Glutamate dehydrogenase 1 reviewed GDH1 - - - - -
Binding DB 50303766
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT020425 Egl nine homolog 1 reviewed EGLN1 - - 1700 -
reviewed BXGT020425 Egl nine homolog 1 reviewed EGLN1 - - 2200 -
reviewed BXGT020425 Egl nine homolog 1 reviewed EGLN1 - - 900 -
reviewed BXGT020425 Egl nine homolog 1 reviewed EGLN1 - - 1000 -
reviewed BXGT021408 Solute carrier family 22 member 2 reviewed Slc22a2 - 700000 - -
reviewed BXGT016060 Solute carrier family 22 member 1 reviewed Slc22a1 - 740000 - -
CHEMBL CHEMBL1686
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q8TCC7 BXGT018794 Solute carrier family 22 member 8 reviewed Transporter SLC22A8 Activity - - -
Q03469 BXGT012717 Glutamate racemase reviewed - murI Km '=' 57000 nM
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Kd '=' 1700 nM
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Kd '=' 900 nM
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 IC50 '=' 740000 nM
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 IC50 '=' 700000 nM
Q9Z0E8 BXGT022397 Solute carrier family 22 member 5 reviewed - Slc22a5 Activity - - -
Q96KS0 BXGT019688 Egl nine homolog 2 reviewed - EGLN2 Km '=' 60000 nM
Q9NWT6 BXGT021234 Hypoxia-inducible factor 1-alpha inhibitor reviewed - HIF1AN Km '=' 25000 nM
Q4U2R8 BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 Activity - - -
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Kd '<' 2000 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 50118 nM
Q9Y694 BXGT022321 Solute carrier family 22 member 7 reviewed Transporter SLC22A7 Activity - - -
Q8VC69 BXGT018912 Solute carrier family 22 member 6 reviewed - Slc22a6 Activity - - -
P13674 BXGT007942 Prolyl 4-hydroxylase subunit alpha-1 reviewed - P4HA1 Km '=' 20000 nM
Q03469 BXGT012717 Glutamate racemase reviewed - murI k cat '=' 0 s-1
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Kd '=' 2200 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 3981 nM
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Km '=' 2000 nM
Q9H6Z9 BXGT020488 Egl nine homolog 3 reviewed - EGLN3 Km '=' 55000 nM
O35956 BXGT004543 Solute carrier family 22 member 6 reviewed - Slc22a6 Activity - - -
Q91WU2 BXGT019304 Solute carrier family 22 member 7 reviewed - Slc22a7 Activity - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 66824 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
O76082 BXGT005175 Solute carrier family 22 member 5 reviewed Transporter SLC22A5 Activity - - -
Q5RLM2 BXGT015647 Solute carrier family 22 member 7 reviewed - Slc22a7 Km '=' 17800 nM
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Kd '=' 1000 nM
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 IC50 - - -
Q4U2R8 BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 Activity '=' 12 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00016 Peanut Arachis hypogaea Nuts
BXGF00022 Oat Avena sativa Cereals and cereal products
BXGF00023 Star fruit Averrhoa carambola Fruits
BXGF00072 Wild carrot Daucus carota Vegetables
BXGF00085 Soy bean Glycine max Soy
BXGF00088 Barley Hordeum vulgare Cereals and cereal products
BXGF00105 Apple Malus pumila Fruits
BXGF00173 Garden tomato (var.) Solanum lycopersicum var. lycopersicum Vegetables
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00180 Tamarind Tamarindus indica Fruits
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00400 French plantain Musa X paradisiaca Fruits
BXGF02062 Glochidion zeylanicum Glochidion zeylanicum Others
BXGF05140 Amomum neoaurantiacum Amomum neoaurantiacum Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease