Showing entry for Palmitoleoyl-protein carboxylesterase NOTUM


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016462
Protein NamePalmitoleoyl-protein carboxylesterase NOTUM
Uniport IdQ6P988
GeneNOTUM
Gene Id147111
DomainPAE
Pfam PF03283  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0030178 negative regulation of Wnt signaling pathway
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:1990697 protein depalmitoleylation
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0052689 carboxylic ester hydrolase activity
molecular function GO:1990699 palmitoleyl hydrolase activity
molecular function GO:0004629 phospholipase C activity
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005576 extracellular region
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-392499 Metabolism of proteins
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-597592 Post-translational protein modification
R-HSA-8957275 Post-translational protein phosphorylation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0542519 BXGD009279 Congenital absence of kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1609433 BXGD013438 Congenital absence of kidneys syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1619700 BXGD013459 RENAL ADYSPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002916 Melatonin 232.28
BXGC0003685 Myristolic acid 226.36
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein