Showing entry for Lysine-specific demethylase 7A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016629
Protein NameLysine-specific demethylase 7A
Uniport IdQ6ZMT4
GeneKDM7A
Gene Id80853
DomainJHD; JmjC; PHD
Pfam PF17811   PF02373   PF00628  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071557 histone H3-K27 demethylation
Biological Process GO:0070544 histone H3-K36 demethylation
Biological Process GO:0033169 histone H3-K9 demethylation
Biological Process GO:0035574 histone H4-K20 demethylation
Biological Process GO:0030901 midbrain development
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
molecular function GO:0016706 2-oxoglutarate-dependent dioxygenase activity
molecular function GO:0071558 histone demethylase activity (H3-K27 specific)
molecular function GO:0051864 histone demethylase activity (H3-K36 specific)
molecular function GO:0032454 histone demethylase activity (H3-K9 specific)
molecular function GO:0035575 histone demethylase activity (H4-K20 specific)
molecular function GO:0005506 iron ion binding
molecular function GO:0035064 methylated histone binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-3214842 HDMs demethylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802957 Oncogenic MAPK signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004565 BXGD000276 Melanoma, B16 Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0003705 Chloride 35.45
BXGC0044092 Daminozide 160.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein