Showing entry for Dihydrofolate reductase 2, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT017629
Protein NameDihydrofolate reductase 2, mitochondrial
Uniport IdQ86XF0
GeneDHFR2
Gene Id200895
DomainDHFR_1
Pfam PF00186  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00670 One carbon pool by folate
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00790 Folate biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01523 Antifolate resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046452 dihydrofolate metabolic process
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0006730 one-carbon metabolic process
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
Biological Process GO:0046653 tetrahydrofolate metabolic process
Biological Process GO:0046105 thymidine biosynthetic process
molecular function GO:0004146 dihydrofolate reductase activity
molecular function GO:0003729 mRNA binding
molecular function GO:0050661 NADP binding
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196757 Metabolism of folate and pterines
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0033310 Epigalocatechin Gallate 458.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein