Showing entry for Aprataxin and PNK-like factor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018351
Protein NameAprataxin and PNK-like factor
Uniport IdQ8IW19
GeneAPLF
Gene Id200558
DomainFHA_2; zf-CCHH
Pfam PF17913   PF10283  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0051106 positive regulation of DNA ligation
Biological Process GO:0045191 regulation of isotype switching
Biological Process GO:0000012 single strand break repair
molecular function GO:0008408 3'-5' exonuclease activity
molecular function GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
molecular function GO:0004520 endodeoxyribonuclease activity
molecular function GO:0046872 metal ion binding
molecular function GO:0000166 nucleotide binding
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0035861 site of double-strand break
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0035369 BXGD002543 Retroviridae Infections Infections
C0043119 BXGD003029 Werner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0202239 BXGD004087 Uric acid measurement (procedure)
C0267797 BXGD005777 Acute hepatitis Digestive System Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002605 Adenosine 267.24
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein