protein

Showing entry for Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT018366
Protein Name	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
Uniport Id	Q8IYD1
Gene	GSPT2
Gene Id	23708
Domain	GTP_EFTU; GTP_EFTU_D2; GTP_EFTU_D3; PAM2
Pfam	PF00009 PF03144 PF03143 PF07145
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
2. Genetic Information Processing	2.2 Translation	hsa03015	mRNA surveillance pathway

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007049	cell cycle
Biological Process	GO:0002184	cytoplasmic translational termination
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process	GO:0006412	translation
molecular function	GO:0003924	GTPase activity
molecular function	GO:0005525	GTP binding
molecular function	GO:0003723	RNA binding
molecular function	GO:0003747	translation release factor activity
cellular component	GO:0005829	cytosol
cellular component	GO:0018444	translation release factor complex

Reactome

Pathway Id	Pathway Name
R-HSA-1266738	Developmental Biology
R-HSA-376176	Signaling by ROBO receptors
R-HSA-392499	Metabolism of proteins
R-HSA-392499	Metabolism of proteins
R-HSA-422475	Axon guidance
R-HSA-72764	Eukaryotic Translation Termination
R-HSA-72764	Eukaryotic Translation Termination
R-HSA-72766	Translation
R-HSA-72766	Translation
R-HSA-8953854	Metabolism of RNA
R-HSA-9010553	Regulation of expression of SLITs and ROBOs
R-HSA-927802	Nonsense-Mediated Decay (NMD)
R-HSA-9675108	Nervous system development
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0004352	BXGD000269	Autistic Disorder	Mental Disorders
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0079731	BXGD003087	B-Cell Lymphomas	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0239946	BXGD005010	Fibrosis, Liver	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0424605	BXGD008535	Developmental delay (disorder)	Mental Disorders
C0454644	BXGD008850	Delayed speech and language development	Behavior and Behavior Mechanisms
C0557874	BXGD009444	Global developmental delay
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C3714756	BXGD019429	Intellectual Disability	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0047692	Gefitinib		446.15

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}