Showing entry for Delayed speech and language development


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD008850
Disease NameDelayed speech and language development
Disease CUI IdC0454644
MeSH Codes F01  
Disease Class NameBehavior and Behavior Mechanisms
Semantic TypeFinding
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00238 BXGT003900 Bone morphogenetic protein receptor type-1B 658 reviewed Kinase
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 773 reviewed Ion channel
O00571 BXGT003938 ATP-dependent RNA helicase DDX3X 1654 reviewed
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O14773 BXGT004096 Tripeptidyl-peptidase 1 1200 reviewed Enzyme
O15297 BXGT004149 Protein phosphatase 1D 8493 reviewed Enzyme
O15305 BXGT004152 Phosphomannomutase 2 5373 reviewed Enzyme
O15399 BXGT004164 Glutamate receptor ionotropic, NMDA 2D 2906 reviewed Ion channel
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O43272 BXGT004580 Proline dehydrogenase 1, mitochondrial 5625 reviewed Enzyme
O60341 BXGT004873 Lysine-specific histone demethylase 1A 23028 reviewed Epigenetic regulator
O60488 BXGT004878 Long-chain-fatty-acid--CoA ligase 4 2182 reviewed Enzyme
O60741 BXGT004897 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 348980 reviewed
O75030 BXGT005096 Microphthalmia-associated transcription factor 4286 reviewed
O75496 BXGT005132 Geminin 51053 reviewed
O75530 BXGT005135 Polycomb protein EED 8726 reviewed
O75914 BXGT005165 Serine/threonine-protein kinase PAK 3 5063 reviewed Kinase
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial 2744 reviewed Enzyme
O95831 BXGT005399 Apoptosis-inducing factor 1, mitochondrial 9131 reviewed Enzyme
P00450 BXGT005544 Ceruloplasmin 1356 reviewed Enzyme
P00558 BXGT005579 Phosphoglycerate kinase 1 5230 reviewed Kinase
P00846 BXGT005674 ATP synthase subunit a 4508 reviewed Transporter
P02458 BXGT005879 Collagen alpha-1(II) chain 1280 reviewed
P04156 BXGT006156 Major prion protein 5621 reviewed
P04350 BXGT006193 Tubulin beta-4A chain 10382 reviewed Cellular structure
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07437 BXGT006624 Tubulin beta chain 203068 reviewed Cellular structure
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10828 BXGT007624 Thyroid hormone receptor beta 7068 reviewed Nuclear receptor
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P12830 BXGT007852 Cadherin-1 999 reviewed
P13637 BXGT007933 Sodium/potassium-transporting ATPase subunit alpha-3 478 reviewed Transporter
P15311 BXGT008106 Ezrin 7430 reviewed Cellular structure
P15735 BXGT008151 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 5261 reviewed Kinase
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P16389 BXGT008221 Potassium voltage-gated channel subfamily A member 2 3737 reviewed Ion channel
P16473 BXGT008234 Thyrotropin receptor 7253 reviewed G-protein coupled receptor
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 2566 reviewed Ion channel
P20933 BXGT008618 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 175 reviewed Enzyme
P21333 BXGT008638 Filamin-A 2316 reviewed
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21675 BXGT008678 Transcription initiation factor TFIID subunit 1 6872 reviewed Kinase
P21817 BXGT008693 Ryanodine receptor 1 6261 reviewed Ion channel
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 54658 reviewed
P22459 BXGT008773 Potassium voltage-gated channel subfamily A member 4 3739 reviewed Ion channel
P22681 BXGT008795 E3 ubiquitin-protein ligase CBL 867 reviewed Enzyme
P24530 BXGT008975 Endothelin receptor type B 1910 reviewed G-protein coupled receptor
P27635 BXGT009194 60S ribosomal protein L10 6134 reviewed Nucleic acid binding
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha 5295 reviewed Kinase
P29033 BXGT009308 Gap junction beta-2 protein 2706 reviewed Cell-cell junction
P30566 BXGT009446 Adenylosuccinate lyase 158 reviewed Enzyme
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P32322 BXGT009624 Pyrroline-5-carboxylate reductase 1, mitochondrial 5831 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35270 BXGT009807 Sepiapterin reductase 6697 reviewed
P35398 BXGT009825 Nuclear receptor ROR-alpha 6095 reviewed Nuclear receptor
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha 6323 reviewed Ion channel
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P41229 BXGT010239 Lysine-specific demethylase 5C 8242 reviewed
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P43155 BXGT010363 Carnitine O-acetyltransferase 1384 reviewed Enzyme
P45381 BXGT010460 Aspartoacylase 443 reviewed
P46019 BXGT010498 Phosphorylase b kinase regulatory subunit alpha, liver isoform 5256 reviewed Kinase
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 2561 reviewed Ion channel
P48029 BXGT010606 Sodium- and chloride-dependent creatine transporter 1 6535 reviewed Transporter
P49419 BXGT010705 Alpha-aminoadipic semialdehyde dehydrogenase 501 reviewed Enzyme
P49588 BXGT010713 Alanine--tRNA ligase, cytoplasmic 16 reviewed Nucleic acid binding
P49591 BXGT010715 Serine--tRNA ligase, cytoplasmic 6301 reviewed Enzyme
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P49959 BXGT010766 Double-strand break repair protein MRE11 4361 reviewed
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P50135 BXGT010776 Histamine N-methyltransferase 3176 reviewed
P50440 BXGT010798 Glycine amidinotransferase, mitochondrial 2628 reviewed
P51649 BXGT010872 Succinate-semialdehyde dehydrogenase, mitochondrial 7915 reviewed Enzyme
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 6197 reviewed Kinase
P54886 BXGT011092 Delta-1-pyrroline-5-carboxylate synthase 5832 reviewed Enzyme
P55201 BXGT011109 Peregrin 7862 reviewed
P55263 BXGT011115 Adenosine kinase 132 reviewed Kinase
P55265 BXGT011117 Double-stranded RNA-specific adenosine deaminase 103 reviewed Enzyme
P58335 BXGT011233 Anthrax toxin receptor 2 118429 reviewed Receptor
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P61981 BXGT011400 14-3-3 protein gamma 7532 reviewed Chaperone
P67775 BXGT011563 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 5515 reviewed
P68400 BXGT011599 Casein kinase II subunit alpha 1457 reviewed Kinase
P78508 BXGT011845 ATP-sensitive inward rectifier potassium channel 10 3766 reviewed Ion channel
P84077 BXGT012031 ADP-ribosylation factor 1 375 reviewed
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
Q00610 BXGT012539 Clathrin heavy chain 1 1213 reviewed Transporter
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B 774 reviewed Ion channel
Q01105 BXGT012569 Protein SET 6418 reviewed Enzyme modulator
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q03393 BXGT012711 6-pyruvoyl tetrahydrobiopterin synthase 5805 reviewed
Q05193 BXGT012810 Dynamin-1 1759 reviewed Enzyme modulator
Q06187 BXGT012860 Tyrosine-protein kinase BTK 695 reviewed Kinase
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D 5144 reviewed
Q09470 BXGT013037 Potassium voltage-gated channel subfamily A member 1 3736 reviewed Ion channel
Q09472 BXGT013038 Histone acetyltransferase p300 2033 reviewed
Q11203 BXGT013218 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase 6487 reviewed
Q12791 BXGT013264 Calcium-activated potassium channel subunit alpha-1 3778 reviewed Ion channel
Q12830 BXGT013268 Nucleosome-remodeling factor subunit BPTF 2186 reviewed
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A 2903 reviewed Ion channel
Q12882 BXGT013276 Dihydropyrimidine dehydrogenase [NADP(+)] 1806 reviewed Enzyme
Q12959 BXGT013283 Disks large homolog 1 1739 reviewed Receptor
Q13002 BXGT013303 Glutamate receptor ionotropic, kainate 2 2898 reviewed Ion channel
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13255 BXGT013332 Metabotropic glutamate receptor 1 2911 reviewed G-protein coupled receptor
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13426 BXGT013353 DNA repair protein XRCC4 7518 reviewed
Q13554 BXGT013374 Calcium/calmodulin-dependent protein kinase type II subunit beta 816 reviewed Kinase
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q14004 BXGT013435 Cyclin-dependent kinase 13 8621 reviewed Kinase
Q14117 BXGT013443 Dihydropyrimidinase 1807 reviewed Enzyme
Q14118 BXGT013444 Dystroglycan 1605 reviewed Receptor
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q14353 BXGT013463 Guanidinoacetate N-methyltransferase 2593 reviewed
Q14376 BXGT013464 UDP-glucose 4-epimerase 2582 reviewed
Q14643 BXGT013493 Inositol 1,4,5-trisphosphate receptor type 1 3708 reviewed Ion channel
Q14671 BXGT013496 Pumilio homolog 1 9698 reviewed Nucleic acid binding
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q14721 BXGT013502 Potassium voltage-gated channel subfamily B member 1 3745 reviewed Ion channel
Q15029 BXGT013524 116 kDa U5 small nuclear ribonucleoprotein component 9343 reviewed Enzyme
Q15131 BXGT013545 Cyclin-dependent kinase 10 8558 reviewed Kinase
Q15139 BXGT013546 Serine/threonine-protein kinase D1 5587 reviewed Kinase
Q15223 BXGT013551 Nectin-1 5818 reviewed
Q15233 BXGT013552 Non-POU domain-containing octamer-binding protein 4841 reviewed Nucleic acid binding
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16099 BXGT013620 Glutamate receptor ionotropic, kainate 4 2900 reviewed Ion channel
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16620 BXGT013645 BDNF/NT-3 growth factors receptor 4915 reviewed Kinase
Q16719 BXGT013662 Kynureninase 8942 reviewed Enzyme
Q7L3T8 BXGT016994 Probable proline--tRNA ligase, mitochondrial 25973 reviewed Enzyme
Q7Z3B3 BXGT017249 KAT8 regulatory NSL complex subunit 1 284058 reviewed
Q86UE8 BXGT017612 Serine/threonine-protein kinase tousled-like 2 11011 reviewed Kinase
Q8IWQ3 BXGT018355 Serine/threonine-protein kinase BRSK2 9024 reviewed Kinase
Q8IWS0 BXGT018356 PHD finger protein 6 84295 reviewed Nucleic acid binding
Q8IYD1 BXGT018366 Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 23708 reviewed Enzyme
Q8N0W4 BXGT018492 Neuroligin-4, X-linked 57502 reviewed
Q8NFD5 BXGT018560 AT-rich interactive domain-containing protein 1B 57492 reviewed
Q8NG31 BXGT018565 Kinetochore scaffold 1 57082 reviewed
Q8TD30 BXGT018805 Alanine aminotransferase 2 84706 reviewed Enzyme
Q8WWQ0 BXGT019003 PH-interacting protein 55023 reviewed Epigenetic regulator
Q8WZ42 BXGT019023 Titin 7273 reviewed Kinase
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92794 BXGT019375 Histone acetyltransferase KAT6A 7994 reviewed Enzyme
Q92796 BXGT019376 Disks large homolog 3 1741 reviewed
Q92834 BXGT019381 X-linked retinitis pigmentosa GTPase regulator 6103 reviewed
Q92963 BXGT019401 GTP-binding protein Rit1 6016 reviewed Enzyme modulator
Q96EQ8 BXGT019652 E3 ubiquitin-protein ligase RNF125 54941 reviewed
Q96S44 BXGT019738 EKC/KEOPS complex subunit TP53RK 112858 reviewed Kinase
Q96SW2 BXGT019743 Protein cereblon 51185 reviewed Enzyme
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha 6326 reviewed Ion channel
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 3028 reviewed Enzyme
Q9BXJ9 BXGT020170 N-alpha-acetyltransferase 15, NatA auxiliary subunit 80155 reviewed Enzyme
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9GZZ9 BXGT020430 Ubiquitin-like modifier-activating enzyme 5 79876 reviewed Enzyme
Q9H4W6 BXGT020478 Transcription factor COE3 253738 reviewed
Q9H9B1 BXGT020501 Histone-lysine N-methyltransferase EHMT1 79813 reviewed Epigenetic regulator
Q9NRF2 BXGT021185 SH2B adapter protein 1 25970 reviewed
Q9NRP7 BXGT021192 Serine/threonine-protein kinase 36 27148 reviewed Kinase
Q9NRR6 BXGT021193 Phosphatidylinositol polyphosphate 5-phosphatase type IV 56623 reviewed
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha 6328 reviewed Ion channel
Q9NZN1 BXGT021279 Interleukin-1 receptor accessory protein-like 1 11141 reviewed Receptor
Q9UDR5 BXGT021667 Alpha-aminoadipic semialdehyde synthase, mitochondrial 10157 reviewed
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B 10765 reviewed Epigenetic regulator
Q9UGM6 BXGT021687 Tryptophan--tRNA ligase, mitochondrial 10352 reviewed
Q9UHX1 BXGT021707 Poly(U)-binding-splicing factor PUF60 22827 reviewed
Q9UKE5 BXGT021741 TRAF2 and NCK-interacting protein kinase 23043 reviewed Kinase
Q9UKM7 BXGT021747 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 11253 reviewed Chaperone
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9ULJ6 BXGT021761 Zinc finger MIZ domain-containing protein 1 57178 reviewed
Q9UPP1 BXGT021800 Histone lysine demethylase PHF8 23133 reviewed
Q9UQD0 BXGT021811 Sodium channel protein type 8 subunit alpha 6334 reviewed Ion channel
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha 815 reviewed Kinase
Q9Y259 BXGT022219 Choline/ethanolamine kinase 1120 reviewed Kinase
Q9Y263 BXGT022220 Phospholipase A-2-activating protein 9373 reviewed Enzyme modulator
Q9Y2H9 BXGT022234 Microtubule-associated serine/threonine-protein kinase 1 22983 reviewed Kinase
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
Q96C86 BXGT022803 m7GpppX diphosphatase 28960 reviewed Enzyme
Q92785 BXGT023424 Zinc finger protein ubi-d4 5977 reviewed Enzyme
Q14657 BXGT024111 EKC/KEOPS complex subunit LAGE3 8270 reviewed
Q9NPF4 BXGT024113 Probable tRNA N6-adenosine threonylcarbamoyltransferase 55644 reviewed Enzyme
Q96L73 BXGT024676 Histone-lysine N-methyltransferase, H3 lysine-36 specific 64324 reviewed Epigenetic regulator
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
Q96DA2 BXGT025522 Ras-related protein Rab-39B 116442 reviewed
Q96HY7 BXGT025609 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial 55526 reviewed
Q05086 BXGT025648 Ubiquitin-protein ligase E3A 7337 reviewed
Q8TAB3 BXGT025819 Protocadherin-19 57526 reviewed
P35251 BXGT025853 Replication factor C subunit 1 5981 reviewed
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
Q8WXI2 BXGT026145 Connector enhancer of kinase suppressor of ras 2 22866 reviewed
Q8N573 BXGT026157 Oxidation resistance protein 1 55074 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease