Showing entry for Adenylosuccinate synthetase isozyme 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018495
Protein NameAdenylosuccinate synthetase isozyme 1
Uniport IdQ8N142
GeneADSS1
Gene Id122622
DomainAdenylsucc_synt
Pfam PF00709  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044208 'de novo' AMP biosynthetic process
Biological Process GO:0006167 AMP biosynthetic process
Biological Process GO:0006531 aspartate metabolic process
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0071257 cellular response to electrical stimulus
Biological Process GO:0006541 glutamine metabolic process
Biological Process GO:0002376 immune system process
Biological Process GO:0046040 IMP metabolic process
Biological Process GO:0009168 purine ribonucleoside monophosphate biosynthetic process
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0042594 response to starvation
molecular function GO:0051015 actin filament binding
molecular function GO:0004019 adenylosuccinate synthase activity
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0042301 phosphate ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis
R-HSA-8956320 Nucleobase biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0022575 BXGD001555 Keratoconjunctivitis Sicca Eye Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153519 BXGD003660 Malignant neoplasm of connective and other soft tissue, site unspecified Neoplasms
C0162154 BXGD003922 Atrophic scar Pathological Conditions, Signs and Symptoms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239043 BXGD004960 Difficulty chewing
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0409338 BXGD008381 Flexion contracture - elbow
C0427055 BXGD008601 Facial Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0560346 BXGD009475 Difficulty running Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0577655 BXGD009536 Quadriceps weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0751336 BXGD010392 Distal Muscular Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332922 BXGD012556 Cervical Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1834696 BXGD013989 Hyporeflexia of lower limbs
C1836057 BXGD014076 Muscle fiber splitting
C1836450 BXGD014117 Distal lower limb muscle weakness
C1836451 BXGD014118 Distal lower limb amyotrophy
C1837323 BXGD014220 Decreased Achilles reflex
C1838579 BXGD014323 Pseudobulbar signs
C1843570 BXGD014595 Tip-toe gait
C1848736 BXGD014970 Distal amyotrophy
C1853932 BXGD015366 Rimmed vacuoles on biopsy
C1854494 BXGD015409 Slow progression
C1858719 BXGD015822 Facial muscle weakness of muscles innervated by CN VII
C1866141 BXGD016379 Foot dorsiflexor weakness
C2230441 BXGD016958 Triceps weakness
C3150620 BXGD018314 Distal upper limb muscle weakness
C4021523 BXGD020650 Upper limb amyotrophy
C4024603 BXGD021335 Atrophy of quadriceps femoris muscle Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4310754 BXGD022651 MYOPATHY, DISTAL, 5
C4692845 BXGD023591 BLEPHAROSPASM, BENIGN ESSENTIAL, SUSCEPTIBILITY TO
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006186 L-Aspartic acid 133.1
BXGC0048845 Guanosine Triphosphate 522.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein