Showing entry for Keratoconjunctivitis Sicca


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001555
Disease NameKeratoconjunctivitis Sicca
Disease CUI IdC0022575
MeSH Codes C11  
Disease Class NameEye Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0002715   HP:0000152   HP:0000478   HP:0001626  
Human Phenotype Ontology TermAbnormality of the immune system; Abnormality of head or neck; Abnormality of the eye; Abnormality of the cardiovascular system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O15553 BXGT004181 Pyrin 4210 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O75844 BXGT005156 CAAX prenyl protease 1 homolog 10269 reviewed Enzyme
O95696 BXGT005390 Bromodomain-containing protein 1 23774 reviewed
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05155 BXGT006328 Plasma protease C1 inhibitor 710 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06396 BXGT006435 Gelsolin 2934 reviewed Cellular structure
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P20701 BXGT008591 Integrin alpha-L 3683 reviewed
P20702 BXGT008592 Integrin alpha-X 3687 reviewed
P29033 BXGT009308 Gap junction beta-2 protein 2706 reviewed Cell-cell junction
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P61769 BXGT011383 Beta-2-microglobulin 567 reviewed Immune response
Q13394 BXGT013347 Putative nucleotidyltransferase MAB21L1 4081 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q15858 BXGT013610 Sodium channel protein type 9 subunit alpha 6335 reviewed Ion channel
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q8N142 BXGT018495 Adenylosuccinate synthetase isozyme 1 122622 reviewed Enzyme
Q96EQ8 BXGT019652 E3 ubiquitin-protein ligase RNF125 54941 reviewed
Q96KB5 BXGT019685 Lymphokine-activated killer T-cell-originated protein kinase 55872 reviewed Kinase
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q9BUF5 BXGT020135 Tubulin beta-6 chain 84617 reviewed Cellular structure
Q9C000 BXGT020206 NACHT, LRR and PYD domains-containing protein 1 22861 reviewed
Q9HC29 BXGT020526 Nucleotide-binding oligomerization domain-containing protein 2 64127 reviewed Enzyme
Q9NSE4 BXGT021207 Isoleucine--tRNA ligase, mitochondrial 55699 reviewed Enzyme
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NZ08 BXGT021266 Endoplasmic reticulum aminopeptidase 1 51752 reviewed Enzyme
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9UQD0 BXGT021811 Sodium channel protein type 8 subunit alpha 6334 reviewed Ion channel
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q9Y4W6 BXGT025025 AFG3-like protein 2 10939 reviewed Enzyme
P19474 BXGT025520 E3 ubiquitin-protein ligase TRIM21 6737 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease