Showing entry for Suppressor of cytokine signaling 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019012
Protein NameSuppressor of cytokine signaling 4
Uniport IdQ8WXH5
GeneSOCS4
Gene Id122809
DomainSH2; SOCS; SOCS_box
Pfam PF00017   PF12610   PF07525  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04917 Prolactin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04930 Type II diabetes mellitus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0046854 phosphatidylinositol phosphorylation
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0040008 regulation of growth
molecular function GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
cellular component GO:0005942 phosphatidylinositol 3-kinase complex
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0202202 BXGD004082 Protein measurement
C0282313 BXGD006803 Condition, Preneoplastic Neoplasms
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0919747 BXGD011439 Cytokine storm
C1269955 BXGD012005 Tumor Cell Invasion
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein