Showing entry for E3 ubiquitin-protein ligase RNF31


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019650
Protein NameE3 ubiquitin-protein ligase RNF31
Uniport IdQ96EP0
GeneRNF31
Gene Id55072
DomainE3_UbLigase_RBR; HOIP-UBA; IBR; PUB; PUB_1
Pfam PF18091   PF16678   PF01485   PF09409   PF18486  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0023035 CD40 signaling pathway
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:1903955 positive regulation of protein targeting to mitochondrion
Biological Process GO:0097039 protein linear polyubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0043130 ubiquitin binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0035631 CD40 receptor complex
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0071797 LUBAC complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0017923 BXGD001154 Glycogen Storage Disease Type IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0024214 BXGD001745 Lymphangiectasis Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032000 BXGD002318 Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2062441 BXGD016897 Influenza A
C3267073 BXGD018613 Autoinflammatory disease
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4014605 BXGD020154 POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCY
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein