adisease

Showing entry for Tumor necrosis

General Disease Information
BXGD Id	BXGD006957
Disease Name	Tumor necrosis
Disease CUI Id	C0333516
MeSH Codes	C23
Disease Class Name	Pathological Conditions, Signs and Symptoms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00767	BXGT003949	Acyl-CoA desaturase	6319	reviewed
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14757	BXGT004092	Serine/threonine-protein kinase Chk1	1111	reviewed	Kinase
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O15553	BXGT004181	Pyrin	4210	reviewed
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O43521	BXGT004598	Bcl-2-like protein 11	10018	reviewed
O60858	BXGT004903	E3 ubiquitin-protein ligase TRIM13	10206	reviewed
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O95150	BXGT005351	Tumor necrosis factor ligand superfamily member 15	9966	reviewed	Signaling
O96013	BXGT005414	Serine/threonine-protein kinase PAK 4	10298	reviewed	Kinase
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08138	BXGT006729	Tumor necrosis factor receptor superfamily member 16	4804	reviewed	Receptor
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08670	BXGT006810	Vimentin	7431	reviewed
P08758	BXGT006821	Annexin A5	308	reviewed
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09210	BXGT006868	Glutathione S-transferase A2	2939	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10144	BXGT007541	Granzyme B	3002	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11678	BXGT007736	Eosinophil peroxidase	8288	reviewed	Enzyme
P12724	BXGT007837	Eosinophil cationic protein	6037	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15151	BXGT008089	Poliovirus receptor	5817	reviewed
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15941	BXGT008176	Mucin-1	4582	reviewed
P16070	BXGT008186	CD44 antigen	960	reviewed
P16109	BXGT008194	P-selectin	6403	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P17861	BXGT008348	X-box-binding protein 1	7494	reviewed
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P22736	BXGT008800	Nuclear receptor subfamily 4 group A member 1	3164	reviewed	Nuclear receptor
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23458	BXGT008868	Tyrosine-protein kinase JAK1	3716	reviewed	Kinase
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27352	BXGT009174	Cobalamin binding intrinsic factor	2694	reviewed
P27815	BXGT009208	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	5141	reviewed
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	3290	reviewed
P29317	BXGT009331	Ephrin type-A receptor 2	1969	reviewed	Kinase
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30086	BXGT009400	Phosphatidylethanolamine-binding protein 1	5037	reviewed	Enzyme modulator
P30536	BXGT009435	Translocator protein	706	reviewed
P31939	BXGT009584	Bifunctional purine biosynthesis protein PURH	471	reviewed	Enzyme
P32302	BXGT009619	C-X-C chemokine receptor type 5	643	reviewed	G-protein coupled receptor
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P35613	BXGT009856	Basigin	682	reviewed
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P43405	BXGT010386	Tyrosine-protein kinase SYK	6850	reviewed	Kinase
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49711	BXGT010728	Transcriptional repressor CTCF	10664	reviewed	Transcription factor
P49767	BXGT010739	Vascular endothelial growth factor C	7424	reviewed	Signaling
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P50750	BXGT010818	Cyclin-dependent kinase 9	1025	reviewed	Kinase
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P55157	BXGT011108	Microsomal triglyceride transfer protein large subunit	4547	reviewed	Transporter
P55212	BXGT011112	Caspase-6	839	reviewed	Enzyme
P56817	BXGT011200	Beta-secretase 1	23621	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61006	BXGT011345	Ras-related protein Rab-8A	4218	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
P78536	BXGT011847	Disintegrin and metalloproteinase domain-containing protein 17	6868	reviewed
P98066	BXGT012225	Tumor necrosis factor-inducible gene 6 protein	7130	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q02763	BXGT012667	Angiopoietin-1 receptor	7010	reviewed	Kinase
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q05397	BXGT012815	Focal adhesion kinase 1	5747	reviewed	Kinase
Q05513	BXGT012820	Protein kinase C zeta type	5590	reviewed	Kinase
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q13093	BXGT013310	Platelet-activating factor acetylhydrolase	7941	reviewed	Enzyme
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q13489	BXGT013364	Baculoviral IAP repeat-containing protein 3	330	reviewed	Enzyme modulator
Q13546	BXGT013372	Receptor-interacting serine/threonine-protein kinase 1	8737	reviewed	Kinase
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15118	BXGT013540	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	5163	reviewed	Kinase
Q15223	BXGT013551	Nectin-1	5818	reviewed
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15582	BXGT013581	Transforming growth factor-beta-induced protein ig-h3	7045	reviewed	Signaling
Q15831	BXGT013604	Serine/threonine-protein kinase STK11	6794	reviewed	Kinase
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16666	BXGT013654	Gamma-interferon-inducible protein 16	3428	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16790	BXGT013670	Carbonic anhydrase 9	768	reviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q6ZQY3	BXGT016636	Acidic amino acid decarboxylase GADL1	339896	reviewed
Q8TD43	BXGT018806	Transient receptor potential cation channel subfamily M member 4	54795	reviewed	Ion channel
Q92887	BXGT019389	Canalicular multispecific organic anion transporter 1	1244	reviewed	Transporter
Q96A70	BXGT019615	Antizyme inhibitor 2	113451	reviewed	Enzyme
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96EP0	BXGT019650	E3 ubiquitin-protein ligase RNF31	55072	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BXH1	BXGT020167	Bcl-2-binding component 3	27113	reviewed
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H0F7	BXGT020435	ADP-ribosylation factor-like protein 6	84100	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9H6X2	BXGT020486	Anthrax toxin receptor 1	84168	reviewed	Receptor
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y572	BXGT022289	Receptor-interacting serine/threonine-protein kinase 3	11035	reviewed	Kinase
Q9Y5S8	BXGT022302	NADPH oxidase 1	27035	reviewed
Q9Y6K9	BXGT022333	NF-kappa-B essential modulator	8517	reviewed	Kinase
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
Q14807	BXGT024966	Kinesin-like protein KIF22	3835	reviewed	Cellular structure
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor
P19532	BXGT026110	Transcription factor E3	7030	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}