Showing entry for Adrenocortical carcinoma


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004241
Disease NameAdrenocortical carcinoma
Disease CUI IdC0206686
MeSH Codes C04   C19  
Disease Class NameNeoplasms; Endocrine System Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0000818   HP:0002664  
Human Phenotype Ontology TermAbnormality of the endocrine system; Neoplasm
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 6446 reviewed Kinase
O00255 BXGT003903 Menin 4221 reviewed
O00512 BXGT003933 B-cell CLL/lymphoma 9 protein 607 reviewed
O14638 BXGT004077 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 5169 reviewed Enzyme
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15169 BXGT004134 Axin-1 8312 reviewed
O95180 BXGT005358 Voltage-dependent T-type calcium channel subunit alpha-1H 8912 reviewed Ion channel
O95750 BXGT005395 Fibroblast growth factor 19 9965 reviewed Signaling
P00450 BXGT005544 Ceruloplasmin 1356 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05023 BXGT006294 Sodium/potassium-transporting ATPase subunit alpha-1 476 reviewed Transporter
P05093 BXGT006313 Steroid 17-alpha-hydroxylase/17,20 lyase 1586 reviewed
P05108 BXGT006317 Cholesterol side-chain cleavage enzyme, mitochondrial 1583 reviewed
P06401 BXGT006436 Progesterone receptor 5241 reviewed Nuclear receptor
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08670 BXGT006810 Vimentin 7431 reviewed
P09104 BXGT006856 Gamma-enolase 2026 reviewed Enzyme
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P11474 BXGT007710 Steroid hormone receptor ERR1 2101 reviewed Nuclear receptor
P11509 BXGT007716 Cytochrome P450 2A6 1548 reviewed
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11717 BXGT007740 Cation-independent mannose-6-phosphate receptor 3482 reviewed Receptor
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P13647 BXGT007937 Keratin, type II cytoskeletal 5 3852 reviewed
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15085 BXGT008077 Carboxypeptidase A1 1357 reviewed Enzyme
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 231 reviewed Enzyme
P15538 BXGT008137 Cytochrome P450 11B1, mitochondrial 1584 reviewed
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha 5566 reviewed Kinase
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P19099 BXGT008456 Cytochrome P450 11B2, mitochondrial 1585 reviewed
P20273 BXGT008557 B-cell receptor CD22 933 reviewed
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P23921 BXGT008927 Ribonucleoside-diphosphate reductase large subunit 6240 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24752 BXGT008993 Acetyl-CoA acetyltransferase, mitochondrial 38 reviewed Enzyme
P25713 BXGT009062 Metallothionein-3 4504 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P34969 BXGT009777 5-hydroxytryptamine receptor 7 3363 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40926 BXGT010207 Malate dehydrogenase, mitochondrial 4191 reviewed Enzyme
P42330 BXGT010301 Aldo-keto reductase family 1 member C3 8644 reviewed Enzyme
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48544 BXGT010641 G protein-activated inward rectifier potassium channel 4 3762 reviewed Ion channel
P48546 BXGT010642 Gastric inhibitory polypeptide receptor 2696 reviewed G-protein coupled receptor
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P51787 BXGT010889 Potassium voltage-gated channel subfamily KQT member 1 3784 reviewed Ion channel
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P52564 BXGT010932 Dual specificity mitogen-activated protein kinase kinase 6 5608 reviewed Kinase
P54802 BXGT011081 Alpha-N-acetylglucosaminidase 4669 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P63261 BXGT011512 Actin, cytoplasmic 2 71 reviewed Cellular structure
P78504 BXGT011844 Protein jagged-1 182 reviewed
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP 331 reviewed Enzyme modulator
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01118 BXGT012570 Sodium channel protein type 7 subunit alpha 6332 reviewed Ion channel
Q01718 BXGT012609 Adrenocorticotropic hormone receptor 4158 reviewed G-protein coupled receptor
Q01970 BXGT012627 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 5331 reviewed Enzyme
Q02643 BXGT012660 Growth hormone-releasing hormone receptor 2692 reviewed G-protein coupled receptor
Q04609 BXGT012768 Glutamate carboxypeptidase 2 2346 reviewed Enzyme
Q06520 BXGT012880 Bile salt sulfotransferase 6822 reviewed
Q07075 BXGT012917 Glutamyl aminopeptidase 2028 reviewed Enzyme
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q13085 BXGT013309 Acetyl-CoA carboxylase 1 31 reviewed
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13233 BXGT013330 Mitogen-activated protein kinase kinase kinase 1 4214 reviewed Kinase
Q13285 BXGT013335 Steroidogenic factor 1 2516 reviewed Nuclear receptor
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13423 BXGT013352 NAD(P) transhydrogenase, mitochondrial 23530 reviewed Enzyme
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase 9833 reviewed Kinase
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15392 BXGT013566 Delta(24)-sterol reductase 1718 reviewed Enzyme
Q15599 BXGT013583 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 9351 reviewed
Q15637 BXGT013586 Splicing factor 1 7536 reviewed Nucleic acid binding
Q15788 BXGT013598 Nuclear receptor coactivator 1 8648 reviewed Kinase
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16658 BXGT013651 Fascin 6624 reviewed Cellular structure
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 51548 reviewed Epigenetic regulator
Q8NBP7 BXGT018541 Proprotein convertase subtilisin/kexin type 9 255738 reviewed Enzyme
Q8WYK2 BXGT019020 Jun dimerization protein 2 122953 reviewed Transcription factor
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q96EP0 BXGT019650 E3 ubiquitin-protein ligase RNF31 55072 reviewed
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q9HCR9 BXGT020537 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 50940 reviewed
Q9NR28 BXGT021178 Diablo homolog, mitochondrial 56616 reviewed
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UER7 BXGT021672 Death domain-associated protein 6 1616 reviewed
Q9UIF7 BXGT021717 Adenine DNA glycosylase 4595 reviewed Enzyme
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q92847 BXGT022673 Growth hormone secretagogue receptor type 1 2693 reviewed G-protein coupled receptor
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
P07954 BXGT023939 Fumarate hydratase, mitochondrial 2271 reviewed Enzyme
O95399 BXGT024237 Urotensin-2 10911 reviewed
P19532 BXGT026110 Transcription factor E3 7030 reviewed
P07320 BXGT026150 Gamma-crystallin D 1421 reviewed
P78329 BXGT026166 Phylloquinone omega-hydroxylase CYP4F2 8529 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease