Showing entry for Macrophage receptor MARCO


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021674
Protein NameMacrophage receptor MARCO
Uniport IdQ9UEW3
GeneMARCO
Gene Id8685
DomainCollagen; SRCR
Pfam PF01391   PF00530  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0043277 apoptotic cell clearance
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0006897 endocytosis
Biological Process GO:0045087 innate immune response
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0006898 receptor-mediated endocytosis
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0038024 cargo receptor activity
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0038187 pattern recognition receptor activity
molecular function GO:0005044 scavenger receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0005581 collagen trimer
cellular component GO:0005737 cytoplasm
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001486 BXGD000056 Adenovirus Infections Infections
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026946 BXGD001951 Mycoses Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037116 BXGD002666 Silicosis Respiratory Tract Diseases; Occupational Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0085435 BXGD003176 Arthritis, Reactive Infections; Musculoskeletal Diseases
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0876973 BXGD011322 Infectious Lung Disorder Infections; Respiratory Tract Diseases
C0949691 BXGD011585 Spondylarthropathies Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1444844 BXGD013079 Juvenile idiopathic arthritis, enthesitis related arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C1609538 BXGD013444 Latent Tuberculosis Infections
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3203653 BXGD018569 IgG4-Related Sclerosing Disease Immune System Diseases
C4021107 BXGD020557 Non-obstructive azoospermia Male Urogenital Diseases
C4087124 BXGD022132 Immunoglobulin G4-Related Disease Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002923 Silicon oxide 60.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein