Showing entry for Kelch-like protein 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021692
Protein NameKelch-like protein 3
Uniport IdQ9UH77
GeneKLHL3
Gene Id26249
DomainBACK; BTB; Kelch_1
Pfam PF07707   PF00651   PF01344  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0072156 distal tubule morphogenesis
Biological Process GO:0050801 ion homeostasis
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0070294 renal sodium ion absorption
Biological Process GO:0061912 selective autophagy
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0003779 actin binding
molecular function GO:0097602 cullin family protein binding
molecular function GO:0005198 structural molecule activity
cellular component GO:0031463 Cul3-RING ubiquitin ligase complex
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0024530 BXGD001783 Malaria Infections
C0033805 BXGD002427 Pseudohypoaldosteronism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085679 BXGD003235 Hyperchloremia Nutritional and Metabolic Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0220666 BXGD004316 ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE IIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0268436 BXGD005946 Pseudohypoaldosteronism, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1449842 BXGD013093 Pseudohypoaldosteronism, Type I, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449843 BXGD013094 Pseudohypoaldosteronism, Type I, Autosomal Recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449844 BXGD013095 Pseudohypoaldosteronism, Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1969073 BXGD016753 Hyperchloremic metabolic acidosis
C2713447 BXGD017501 Hyperpotassemia and Hypertension, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3469605 BXGD018917 PSEUDOHYPOALDOSTERONISM, TYPE IID Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3889261 BXGD020003 Other License Status
C4288936 BXGD022490 Hyperkalemic Mineralocorticoid Resistance
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein