Showing entry for ATPase MORC2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022345
Protein NameATPase MORC2
Uniport IdQ9Y6X9
GeneMORC2
Gene Id22880
DomainHATPase_c_3; Morc6_S5; zf-CW
Pfam PF17942   PF07496  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
Biological Process GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000792 heterochromatin
cellular component GO:0016363 nuclear matrix
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-75105 Fatty acyl-CoA biosynthesis
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027832 BXGD002048 Neurofibromatosis 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0034880 BXGD002488 Hyperacusis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152217 BXGD003560 Exophoria Eye Diseases; Nervous System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205713 BXGD004114 Roussy-Levy Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231274 BXGD004490 Intolerant of heat
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235198 BXGD004729 Unable to concentrate Mental Disorders
C0239842 BXGD005001 Tremor of hands
C0240309 BXGD005029 Hyperplasia of midface
C0241703 BXGD005109 High pitched voice
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263401 BXGD005298 Cutis marmorata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases; Wounds and Injuries
C0270911 BXGD006128 Charcot-Marie-Tooth Disease, Type Ia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270912 BXGD006129 Charcot-Marie-Tooth Disease, Type Ib Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0426415 BXGD008560 Large nose
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684219 BXGD009789 Myokymia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751036 BXGD010299 Hereditary Motor and Sensory Neuropathy Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0920299 BXGD011465 Overriding toe Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1837098 BXGD014198 Easy fatigability
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1849043 BXGD015000 Soft, doughy skin
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1854408 BXGD015397 Glabellar hemangioma Neoplasms
C1854494 BXGD015409 Slow progression
C1855580 BXGD015515 Exercise-induced muscle fatigue
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1866141 BXGD016379 Foot dorsiflexor weakness
C1867131 BXGD016440 Broad hallux
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3665983 BXGD019314 Oral aversion
C4022748 BXGD020979 Focal T2 hyperintense brainstem lesion
C4022774 BXGD020997 Focal T2 hyperintense thalamic lesion
C4022968 BXGD021047 Abnormal hypothalamus physiology
C4023802 BXGD021266 Hyperextensibility of the knee
C4023808 BXGD021268 Hyperextensibility at elbow
C4024165 BXGD021293 Prominent ear helix
C4024829 BXGD021432 Nevus flammeus nuchae Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4024926 BXGD021478 Focal T2 hyperintense basal ganglia lesion
C4225243 BXGD022188 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2Z
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein