Showing entry for Solute carrier family 12 member 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024658
Protein NameSolute carrier family 12 member 4
Uniport IdQ9UP95
GeneSLC12A4
Gene Id6560
Domain_permease; SLC12
Pfam PF00324   PF03522  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0140157 ammonium import across plasma membrane
Biological Process GO:0006884 cell volume homeostasis
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0055064 chloride ion homeostasis
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0055075 potassium ion homeostasis
Biological Process GO:1990573 potassium ion import across plasma membrane
molecular function GO:0008519 ammonium transmembrane transporter activity
molecular function GO:0015379 potassium:chloride symporter activity
molecular function GO:0019901 protein kinase binding
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-382551 Transport of small molecules
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-426117 Cation-coupled Chloride cotransporters
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0024534 BXGD001784 Malaria, Cerebral Infections; Nervous System Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0342895 BXGD007579 Fish-Eye Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein