adisease

Showing entry for Dehydration

General Disease Information
BXGD Id	BXGD000701
Disease Name	Dehydration
Disease CUI Id	C0011175
MeSH Codes	C23 C18
Disease Class Name	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001939
Human Phenotype Ontology Term	Abnormality of metabolism/homeostasis
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00141	BXGT003882	Serine/threonine-protein kinase Sgk1	6446	reviewed	Kinase
O00204	BXGT003893	Sulfotransferase family cytosolic 2B member 1	6820	reviewed
O00555	BXGT003936	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	773	reviewed	Ion channel
O15554	BXGT004182	Intermediate conductance calcium-activated potassium channel protein 4	3783	reviewed	Ion channel
O43521	BXGT004598	Bcl-2-like protein 11	10018	reviewed
O43570	BXGT004601	Carbonic anhydrase 12	771	reviewed
O43612	BXGT004605	Orexin	3060	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60931	BXGT004911	Cystinosin	1497	reviewed
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O95342	BXGT005373	Bile salt export pump	8647	reviewed	Transporter
O95644	BXGT005389	Nuclear factor of activated T-cells, cytoplasmic 1	4772	reviewed	Transcription factor
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P02730	BXGT005935	Band 3 anion transport protein	6521	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05108	BXGT006317	Cholesterol side-chain cleavage enzyme, mitochondrial	1583	reviewed
P05165	BXGT006334	Propionyl-CoA carboxylase alpha chain, mitochondrial	5095	reviewed	Enzyme
P05166	BXGT006335	Propionyl-CoA carboxylase beta chain, mitochondrial	5096	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08572	BXGT006791	Collagen alpha-2(IV) chain	1284	reviewed
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09848	BXGT006929	Lactase-phlorizin hydrolase	3938	reviewed	Enzyme
P0CG48	BXGT007468	Polyubiquitin-C	7316	reviewed	Nucleic acid binding
P0DMV8	BXGT007509	Heat shock 70 kDa protein 1A	3304	reviewed
P0DMV9	BXGT007510	Heat shock 70 kDa protein 1B	3304	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11142	BXGT007658	Heat shock cognate 71 kDa protein	3312	reviewed
P11912	BXGT007758	B-cell antigen receptor complex-associated protein alpha chain	973	reviewed	Receptor
P12277	BXGT007789	Creatine kinase B-type	1152	reviewed	Kinase
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P15085	BXGT008077	Carboxypeptidase A1	1357	reviewed	Enzyme
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15814	BXGT008159	Immunoglobulin lambda-like polypeptide 1	3543	reviewed
P16144	BXGT008200	Integrin beta-4	3691	reviewed	Receptor
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P19099	BXGT008456	Cytochrome P450 11B2, mitochondrial	1585	reviewed
P19623	BXGT008503	Spermidine synthase	6723	reviewed	Enzyme
P20132	BXGT008546	L-serine dehydratase/L-threonine deaminase	10993	reviewed	Enzyme
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21439	BXGT008649	Phosphatidylcholine translocator ABCB4	5244	reviewed	Transporter
P21549	BXGT008661	Serine--pyruvate aminotransferase	189	reviewed	Enzyme
P22033	BXGT008721	Methylmalonyl-CoA mutase, mitochondrial	4594	reviewed	Enzyme
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24752	BXGT008993	Acetyl-CoA acetyltransferase, mitochondrial	38	reviewed	Enzyme
P25929	BXGT009078	Neuropeptide Y receptor type 1	4886	reviewed	G-protein coupled receptor
P27708	BXGT009202	CAD protein	790	reviewed	Enzyme
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30101	BXGT009402	Protein disulfide-isomerase A3	2923	reviewed
P30518	BXGT009428	Vasopressin V2 receptor	554	reviewed	G-protein coupled receptor
P30536	BXGT009435	Translocator protein	706	reviewed
P31639	BXGT009556	Sodium/glucose cotransporter 2	6524	reviewed	Transporter
P32926	BXGT009680	Desmoglein-3	1830	reviewed	Cell adhesion
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P35914	BXGT009880	Hydroxymethylglutaryl-CoA lyase, mitochondrial	3155	reviewed	Enzyme
P37088	BXGT009961	Amiloride-sensitive sodium channel subunit alpha	6337	reviewed	Ion channel
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P41231	BXGT010240	P2Y purinoceptor 2	5029	reviewed	G-protein coupled receptor
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P47712	BXGT010577	Cytosolic phospholipase A2	5321	reviewed	Enzyme
P48048	BXGT010610	ATP-sensitive inward rectifier potassium channel 1	3758	reviewed	Ion channel
P48065	BXGT010617	Sodium- and chloride-dependent betaine transporter	6539	reviewed	Transporter
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P50053	BXGT010769	Ketohexokinase	3795	reviewed	Kinase
P51168	BXGT010842	Amiloride-sensitive sodium channel subunit beta	6338	reviewed	Ion channel
P51170	BXGT010843	Amiloride-sensitive sodium channel subunit gamma	6340	reviewed	Ion channel
P51512	BXGT010850	Matrix metalloproteinase-16	4325	reviewed	Enzyme
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51843	BXGT010897	Nuclear receptor subfamily 0 group B member 1	190	reviewed	Nuclear receptor
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P54819	BXGT011084	Adenylate kinase 2, mitochondrial	204	reviewed	Kinase
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61626	BXGT011382	Lysozyme C	4069	reviewed
P63104	BXGT011499	14-3-3 protein zeta/delta	7534	reviewed	Chaperone
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P78508	BXGT011845	ATP-sensitive inward rectifier potassium channel 10	3766	reviewed	Ion channel
P98177	BXGT012232	Forkhead box protein O4	4303	reviewed
Q00796	BXGT012549	Sorbitol dehydrogenase	6652	reviewed	Enzyme
Q01968	BXGT012626	Inositol polyphosphate 5-phosphatase OCRL-1	4952	reviewed	Enzyme
Q07973	BXGT012952	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	1591	reviewed	Enzyme
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q12882	BXGT013276	Dihydropyrimidine dehydrogenase [NADP(+)]	1806	reviewed	Enzyme
Q13085	BXGT013309	Acetyl-CoA carboxylase 1	31	reviewed
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13285	BXGT013335	Steroidogenic factor 1	2516	reviewed	Nuclear receptor
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q13621	BXGT013383	Solute carrier family 12 member 1	6557	reviewed	Transporter
Q14654	BXGT013495	ATP-sensitive inward rectifier potassium channel 11	3767	reviewed	Ion channel
Q15149	BXGT013547	Plectin	5339	reviewed	Cellular structure
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q8NCC3	BXGT018546	Group XV phospholipase A2	23659	reviewed	Enzyme
Q8WTS1	BXGT018985	1-acylglycerol-3-phosphate O-acyltransferase ABHD5	51099	reviewed
Q96EY8	BXGT019655	Corrinoid adenosyltransferase	326625	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PE7	BXGT019707	Methylmalonyl-CoA epimerase, mitochondrial	84693	reviewed	Enzyme
Q99527	BXGT019930	G-protein coupled estrogen receptor 1	2852	reviewed	G-protein coupled receptor
Q9C000	BXGT020206	NACHT, LRR and PYD domains-containing protein 1	22861	reviewed
Q9GZT4	BXGT020424	Serine racemase	63826	reviewed	Enzyme
Q9H7Z6	BXGT020493	Histone acetyltransferase KAT8	84148	reviewed
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9NP55	BXGT021141	BPI fold-containing family A member 1	51297	reviewed
Q9NR19	BXGT021175	Acetyl-coenzyme A synthetase, cytoplasmic	55902	reviewed	Enzyme
Q9NRN7	BXGT021191	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	60496	reviewed	Enzyme
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UBT2	BXGT021663	SUMO-activating enzyme subunit 2	10054	reviewed	Enzyme
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q9ULV0	BXGT021763	Unconventional myosin-Vb	4645	reviewed	Cellular structure
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y5Y6	BXGT022308	Suppressor of tumorigenicity 14 protein	6768	reviewed	Enzyme
P35232	BXGT022663	Prohibitin	5245	reviewed
Q92482	BXGT022676	Aquaporin-3	360	reviewed	Ion channel
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
Q9UP95	BXGT024658	Solute carrier family 12 member 4	6560	reviewed	Transporter
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}