Showing entry for DNA ligase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025156
Protein NameDNA ligase 1
Uniport IdP18858
GeneLIG1
Gene Id3978
DomainDNA_ligase_A_C; DNA_ligase_A_M; DNA_ligase_A_N
Pfam PF04679   PF01068   PF04675  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03030 DNA replication
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
2. Genetic Information Processing 2.4 Replication and repair hsa03420 Nucleotide excision repair
2. Genetic Information Processing 2.4 Replication and repair hsa03430 Mismatch repair
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0006284 base-excision repair
Biological Process GO:0051301 cell division
Biological Process GO:0071897 DNA biosynthetic process
Biological Process GO:0006266 DNA ligation
Biological Process GO:0051103 DNA ligation involved in DNA repair
Biological Process GO:0006310 DNA recombination
Biological Process GO:0006281 DNA repair
Biological Process GO:0006273 lagging strand elongation
Biological Process GO:0006298 mismatch repair
Biological Process GO:0006297 nucleotide-excision repair, DNA gap filling
Biological Process GO:1903461 Okazaki fragment processing involved in mitotic DNA replication
Biological Process GO:0006283 transcription-coupled nucleotide-excision repair
molecular function GO:0005524 ATP binding
molecular function GO:0003677 DNA binding
molecular function GO:0003910 DNA ligase (ATP) activity
molecular function GO:0003909 DNA ligase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-157579 Telomere Maintenance
R-HSA-162587 HIV Life Cycle
R-HSA-162594 Early Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-174414 Processive synthesis on the C-strand of the telomere
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis
R-HSA-180786 Extension of Telomeres
R-HSA-5358508 Mismatch Repair
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5663205 Infectious disease
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-69183 Processive synthesis on the lagging strand
R-HSA-69186 Lagging Strand Synthesis
R-HSA-69190 DNA strand elongation
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-73884 Base Excision Repair
R-HSA-73886 Chromosome Maintenance
R-HSA-73894 DNA Repair
R-HSA-73933 Resolution of Abasic Sites (AP sites)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263641 BXGD005337 Epithelial hyperplasia of skin Pathological Conditions, Signs and Symptoms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C4016019 BXGD020257 DNA Ligase I Deficiency
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein