adisease

Showing entry for Malnutrition

General Disease Information
BXGD Id	BXGD003942
Disease Name	Malnutrition
Disease CUI Id	C0162429
MeSH Codes	C18
Disease Class Name	Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0025031
Human Phenotype Ontology Term	Abnormality of the digestive system
Disease Ontology Id	DOID:0014667
Disease Ontology Class Name	disease of metabolism
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
A5YKK6	BXGT001378	CCR4-NOT transcription complex subunit 1	23019	reviewed	Transcription factor
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14939	BXGT004115	Phospholipase D2	5338	reviewed
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O43181	BXGT004576	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	4724	reviewed
O43353	BXGT004589	Receptor-interacting serine/threonine-protein kinase 2	8767	reviewed	Kinase
O43521	BXGT004598	Bcl-2-like protein 11	10018	reviewed
O43612	BXGT004605	Orexin	3060	reviewed
O43678	BXGT004613	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	4695	reviewed	Enzyme
O43776	BXGT004624	Asparagine--tRNA ligase, cytoplasmic	4677	reviewed	Enzyme
O43826	BXGT004629	Glucose-6-phosphate exchanger SLC37A4	2542	reviewed	Transporter
O60427	BXGT004875	Acyl-CoA (8-3)-desaturase	3992	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O75030	BXGT005096	Microphthalmia-associated transcription factor	4286	reviewed
O75251	BXGT005107	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	374291	reviewed
O75369	BXGT005119	Filamin-B	2317	reviewed
O75923	BXGT005166	Dysferlin	8291	reviewed	Transporter
O76054	BXGT005172	SEC14-like protein 2	23541	reviewed
O94762	BXGT005329	ATP-dependent DNA helicase Q5	9400	reviewed	Enzyme
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
O95864	BXGT005403	Acyl-CoA 6-desaturase	9415	reviewed
P00338	BXGT005504	L-lactate dehydrogenase A chain	3939	reviewed	Enzyme
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00480	BXGT005551	Ornithine carbamoyltransferase, mitochondrial	5009	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00742	BXGT005636	Coagulation factor X	2159	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P00918	BXGT005690	Carbonic anhydrase 2	760	reviewed
P01008	BXGT005713	Antithrombin-III	462	reviewed	Enzyme modulator
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01833	BXGT005788	Polymeric immunoglobulin receptor	5284	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02655	BXGT005912	Apolipoprotein C-II	344	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02765	BXGT005952	Alpha-2-HS-glycoprotein	197	reviewed	Enzyme modulator
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P03951	BXGT006117	Coagulation factor XI	2160	reviewed	Enzyme
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04070	BXGT006143	Vitamin K-dependent protein C	5624	reviewed	Enzyme
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P04745	BXGT006255	Alpha-amylase 1	278	reviewed
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05062	BXGT006305	Fructose-bisphosphate aldolase B	229	reviewed
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05155	BXGT006328	Plasma protease C1 inhibitor	710	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05546	BXGT006367	Heparin cofactor 2	3053	reviewed	Enzyme modulator
P06276	BXGT006430	Cholinesterase	590	reviewed
P06401	BXGT006436	Progesterone receptor	5241	reviewed	Nuclear receptor
P06681	BXGT006468	Complement C2	717	reviewed
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07093	BXGT006544	Glia-derived nexin	5270	reviewed	Enzyme modulator
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P07814	BXGT006680	Bifunctional glutamate/proline--tRNA ligase	2058	reviewed	Enzyme
P07902	BXGT006697	Galactose-1-phosphate uridylyltransferase	2592	reviewed	Enzyme
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08174	BXGT006739	Complement decay-accelerating factor	1604	reviewed
P08603	BXGT006798	Complement factor H	3075	reviewed
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09848	BXGT006929	Lactase-phlorizin hydrolase	3938	reviewed	Enzyme
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12830	BXGT007852	Cadherin-1	999	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P13866	BXGT007963	Sodium/glucose cotransporter 1	6523	reviewed	Transporter
P14060	BXGT007978	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	3283	reviewed	Enzyme
P14410	BXGT008009	Sucrase-isomaltase, intestinal	6476	reviewed	Enzyme
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14550	BXGT008019	Aldo-keto reductase family 1 member A1	10327	reviewed	Enzyme
P14616	BXGT008026	Insulin receptor-related protein	3645	reviewed	Kinase
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15090	BXGT008079	Fatty acid-binding protein, adipocyte	2167	reviewed
P15941	BXGT008176	Mucin-1	4582	reviewed
P16109	BXGT008194	P-selectin	6403	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19971	BXGT008537	Thymidine phosphorylase	1890	reviewed	Enzyme
P20132	BXGT008546	L-serine dehydratase/L-threonine deaminase	10993	reviewed	Enzyme
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21439	BXGT008649	Phosphatidylcholine translocator ABCB4	5244	reviewed	Transporter
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P22087	BXGT008729	rRNA 2'-O-methyltransferase fibrillarin	2091	reviewed	Enzyme
P22352	BXGT008758	Glutathione peroxidase 3	2878	reviewed	Enzyme
P22680	BXGT008794	Cholesterol 7-alpha-monooxygenase	1581	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24752	BXGT008993	Acetyl-CoA acetyltransferase, mitochondrial	38	reviewed	Enzyme
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P27352	BXGT009174	Cobalamin binding intrinsic factor	2694	reviewed
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P30043	BXGT009394	Flavin reductase (NADPH)	645	reviewed	Enzyme
P30793	BXGT009466	GTP cyclohydrolase 1	2643	reviewed	Enzyme
P30988	BXGT009491	Calcitonin receptor	799	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P32320	BXGT009622	Cytidine deaminase	978	reviewed	Enzyme
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P34947	BXGT009774	G protein-coupled receptor kinase 5	2869	reviewed	Kinase
P35414	BXGT009829	Apelin receptor	187	reviewed	G-protein coupled receptor
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P36021	BXGT009893	Monocarboxylate transporter 8	6567	reviewed	Transporter
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38571	BXGT010054	Lysosomal acid lipase/cholesteryl ester hydrolase	3988	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P41208	BXGT010233	Centrin-2	1069	reviewed	Calcium-binding protein
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42858	BXGT010341	Huntingtin	3064	reviewed
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P46063	BXGT010501	ATP-dependent DNA helicase Q1	5965	reviewed	Enzyme
P48029	BXGT010606	Sodium- and chloride-dependent creatine transporter 1	6535	reviewed	Transporter
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P50406	BXGT010796	5-hydroxytryptamine receptor 6	3362	reviewed	G-protein coupled receptor
P50440	BXGT010798	Glycine amidinotransferase, mitochondrial	2628	reviewed
P52788	BXGT010953	Spermine synthase	6611	reviewed
P53396	BXGT010988	ATP-citrate synthase	47	reviewed	Enzyme
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P55055	BXGT011101	Oxysterols receptor LXR-beta	7376	reviewed	Nuclear receptor
P60174	BXGT011294	Triosephosphate isomerase	7167	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60891	BXGT011337	Ribose-phosphate pyrophosphokinase 1	5631	reviewed	Kinase
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P63261	BXGT011512	Actin, cytoplasmic 2	71	reviewed	Cellular structure
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P81172	BXGT011935	Hepcidin	57817	reviewed
Q00796	BXGT012549	Sorbitol dehydrogenase	6652	reviewed	Enzyme
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q03518	BXGT012723	Antigen peptide transporter 1	6890	reviewed	Transporter
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q04844	BXGT012789	Acetylcholine receptor subunit epsilon	1145	reviewed	Ion channel
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q10589	BXGT013203	Bone marrow stromal antigen 2	684	reviewed
Q12882	BXGT013276	Dihydropyrimidine dehydrogenase [NADP(+)]	1806	reviewed	Enzyme
Q12959	BXGT013283	Disks large homolog 1	1739	reviewed	Receptor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13526	BXGT013369	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5300	reviewed
Q13541	BXGT013371	Eukaryotic translation initiation factor 4E-binding protein 1	1978	reviewed	Nucleic acid binding
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14353	BXGT013463	Guanidinoacetate N-methyltransferase	2593	reviewed
Q15223	BXGT013551	Nectin-1	5818	reviewed
Q15582	BXGT013581	Transforming growth factor-beta-induced protein ig-h3	7045	reviewed	Signaling
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16674	BXGT013655	Melanoma-derived growth regulatory protein	8190	reviewed
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q6ZVN8	BXGT016641	Hemojuvelin	148738	reviewed
Q76LX8	BXGT016870	A disintegrin and metalloproteinase with thrombospondin motifs 13	11093	reviewed	Enzyme
Q8TEK3	BXGT018822	Histone-lysine N-methyltransferase, H3 lysine-79 specific	84444	reviewed	Epigenetic regulator
Q92959	BXGT019400	Solute carrier organic anion transporter family member 2A1	6578	reviewed	Transporter
Q969Q1	BXGT019610	E3 ubiquitin-protein ligase TRIM63	84676	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99759	BXGT019960	Mitogen-activated protein kinase kinase kinase 3	4215	reviewed	Kinase
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9HCN6	BXGT020535	Platelet glycoprotein VI	51206	reviewed	Receptor
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NYA1	BXGT021254	Sphingosine kinase 1	8877	reviewed	Kinase
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UHD2	BXGT021697	Serine/threonine-protein kinase TBK1	29110	reviewed	Kinase
Q9UKA9	BXGT021740	Polypyrimidine tract-binding protein 2	58155	reviewed
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q9ULV0	BXGT021763	Unconventional myosin-Vb	4645	reviewed	Cellular structure
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y600	BXGT022311	Cysteine sulfinic acid decarboxylase	51380	reviewed	Enzyme
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
Q5JP69	BXGT022691	C3/C5 convertase	717	unreviewed
Q15397	BXGT022873	Pumilio homolog 3	9933	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
O14793	BXGT023280	Growth/differentiation factor 8	2660	reviewed	Signaling
O60502	BXGT023392	Protein O-GlcNAcase	10724	reviewed
Q9H8S9	BXGT023504	MOB kinase activator 1A	55233	reviewed	Enzyme modulator
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
Q9UKP6	BXGT024239	Urotensin-2 receptor	2837	reviewed	G-protein coupled receptor
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
Q9H0W8	BXGT024746	Protein SMG9	56006	reviewed
Q695T7	BXGT024794	Sodium-dependent neutral amino acid transporter B(0)AT1	340024	reviewed
P98082	BXGT025047	Disabled homolog 2	1601	reviewed	Signaling
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
P18858	BXGT025156	DNA ligase 1	3978	reviewed	Enzyme
P27918	BXGT025485	Properdin	5199	reviewed
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed
V9HWB9	BXGT026149	L-lactate dehydrogenase	3939	unreviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}