adisease

Showing entry for Cerebellar Ataxia

General Disease Information
BXGD Id	BXGD000475
Disease Name	Cerebellar Ataxia
Disease CUI Id	C0007758
MeSH Codes	C23 C10
Disease Class Name	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00305	BXGT003907	Voltage-dependent L-type calcium channel subunit beta-4	785	reviewed	Ion channel
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O00522	BXGT003935	Krev interaction trapped protein 1	889	reviewed
O00555	BXGT003936	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	773	reviewed	Ion channel
O14773	BXGT004096	Tripeptidyl-peptidase 1	1200	reviewed	Enzyme
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O15305	BXGT004152	Phosphomannomutase 2	5373	reviewed	Enzyme
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43424	BXGT004592	Glutamate receptor ionotropic, delta-2	2895	reviewed	Ion channel
O43497	BXGT004596	Voltage-dependent T-type calcium channel subunit alpha-1G	8913	reviewed	Ion channel
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43813	BXGT004628	Glutathione S-transferase LANCL1	10314	reviewed
O43896	BXGT004632	Kinesin-like protein KIF1C	10749	reviewed	Cellular structure
O60242	BXGT004861	Adhesion G protein-coupled receptor B3	577	reviewed	G-protein coupled receptor
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60313	BXGT004871	Dynamin-like 120 kDa protein, mitochondrial	4976	reviewed	Enzyme modulator
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
O95405	BXGT005379	Zinc finger FYVE domain-containing protein 9	9372	reviewed
O95551	BXGT005384	Tyrosyl-DNA phosphodiesterase 2	51567	reviewed
O95831	BXGT005399	Apoptosis-inducing factor 1, mitochondrial	9131	reviewed	Enzyme
O95970	BXGT005409	Leucine-rich glioma-inactivated protein 1	9211	reviewed
O96017	BXGT005415	Serine/threonine-protein kinase Chk2	11200	reviewed	Kinase
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00846	BXGT005674	ATP synthase subunit a	4508	reviewed	Transporter
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P03905	BXGT006113	NADH-ubiquinone oxidoreductase chain 4	4538	reviewed	Enzyme
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04156	BXGT006156	Major prion protein	5621	reviewed
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P05129	BXGT006322	Protein kinase C gamma type	5582	reviewed	Kinase
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06241	BXGT006429	Tyrosine-protein kinase Fyn	2534	reviewed	Kinase
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06493	BXGT006445	Cyclin-dependent kinase 1	983	reviewed	Kinase
P06753	BXGT006498	Tropomyosin alpha-3 chain	7170	reviewed	Cellular structure
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07902	BXGT006697	Galactose-1-phosphate uridylyltransferase	2592	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08397	BXGT006768	Porphobilinogen deaminase	3145	reviewed	Enzyme
P08559	BXGT006788	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	5160	reviewed
P08865	BXGT006832	40S ribosomal protein SA	3921	reviewed	Nucleic acid binding
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09238	BXGT006875	Stromelysin-2	4319	reviewed	Enzyme
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P09936	BXGT006943	Ubiquitin carboxyl-terminal hydrolase isozyme L1	7345	reviewed	Enzyme
P0DP23	BXGT007520	Calmodulin-1	808	reviewed
P0DP24	BXGT007521	Calmodulin-2	808	reviewed
P10153	BXGT007544	Non-secretory ribonuclease	6036	reviewed
P10253	BXGT007550	Lysosomal alpha-glucosidase	2548	reviewed	Enzyme
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11387	BXGT007696	DNA topoisomerase 1	7150	reviewed	Enzyme
P11388	BXGT007697	DNA topoisomerase 2-alpha	7153	reviewed
P13637	BXGT007933	Sodium/potassium-transporting ATPase subunit alpha-3	478	reviewed	Transporter
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16389	BXGT008221	Potassium voltage-gated channel subfamily A member 2	3737	reviewed	Ion channel
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17658	BXGT008326	Potassium voltage-gated channel subfamily A member 6	3742	reviewed	Ion channel
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19634	BXGT008504	Sodium/hydrogen exchanger 1	6548	reviewed	Transporter
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22460	BXGT008774	Potassium voltage-gated channel subfamily A member 5	3741	reviewed	Ion channel
P22557	BXGT008783	5-aminolevulinate synthase, erythroid-specific, mitochondrial	212	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28676	BXGT009284	Grancalcin	25801	reviewed
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P30307	BXGT009421	M-phase inducer phosphatase 3	995	reviewed	Enzyme
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35219	BXGT009797	Carbonic anhydrase-related protein	767	reviewed
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P35498	BXGT009838	Sodium channel protein type 1 subunit alpha	6323	reviewed	Ion channel
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42658	BXGT010327	Dipeptidyl aminopeptidase-like protein 6	1804	reviewed	Enzyme
P42858	BXGT010341	Huntingtin	3064	reviewed
P43003	BXGT010347	Excitatory amino acid transporter 1	6507	reviewed	Transporter
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46939	BXGT010555	Utrophin	7402	reviewed
P48547	BXGT010643	Potassium voltage-gated channel subfamily C member 1	3746	reviewed	Ion channel
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49448	BXGT010709	Glutamate dehydrogenase 2, mitochondrial	2747	reviewed	Enzyme
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49588	BXGT010713	Alanine--tRNA ligase, cytoplasmic	16	reviewed	Nucleic acid binding
P49638	BXGT010720	Alpha-tocopherol transfer protein	7274	reviewed	Transporter
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49914	BXGT010762	5-formyltetrahydrofolate cyclo-ligase	10588	reviewed	Enzyme
P49916	BXGT010764	DNA ligase 3	3980	reviewed	Enzyme
P49959	BXGT010766	Double-strand break repair protein MRE11	4361	reviewed
P50993	BXGT010826	Sodium/potassium-transporting ATPase subunit alpha-2	477	reviewed	Transporter
P51665	BXGT010874	26S proteasome non-ATPase regulatory subunit 7	5713	reviewed	Enzyme
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54578	BXGT011056	Ubiquitin carboxyl-terminal hydrolase 14	9097	reviewed	Enzyme
P54803	BXGT011082	Galactocerebrosidase	2581	reviewed
P54886	BXGT011092	Delta-1-pyrroline-5-carboxylate synthase	5832	reviewed	Enzyme
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P78352	BXGT011836	Disks large homolog 4	1742	reviewed	Receptor
P78508	BXGT011845	ATP-sensitive inward rectifier potassium channel 10	3766	reviewed	Ion channel
P82251	BXGT011971	b(0,+)-type amino acid transporter 1	11136	reviewed	Transporter
P98155	BXGT012226	Very low-density lipoprotein receptor	7436	reviewed
Q01082	BXGT012567	Spectrin beta chain, non-erythrocytic 1	6711	reviewed
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q05193	BXGT012810	Dynamin-1	1759	reviewed	Enzyme modulator
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q09470	BXGT013037	Potassium voltage-gated channel subfamily A member 1	3736	reviewed	Ion channel
Q12756	BXGT013261	Kinesin-like protein KIF1A	547	reviewed	Cellular structure
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13255	BXGT013332	Metabotropic glutamate receptor 1	2911	reviewed	G-protein coupled receptor
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13363	BXGT013344	C-terminal-binding protein 1	1487	reviewed	Transcription factor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13885	BXGT013400	Tubulin beta-2A chain	7280	reviewed	Cellular structure
Q14003	BXGT013434	Potassium voltage-gated channel subfamily C member 3	3748	reviewed	Ion channel
Q14232	BXGT013457	Translation initiation factor eIF-2B subunit alpha	1967	reviewed
Q14643	BXGT013493	Inositol 1,4,5-trisphosphate receptor type 1	3708	reviewed	Ion channel
Q14671	BXGT013496	Pumilio homolog 1	9698	reviewed	Nucleic acid binding
Q14721	BXGT013502	Potassium voltage-gated channel subfamily B member 1	3745	reviewed	Ion channel
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q16099	BXGT013620	Glutamate receptor ionotropic, kainate 4	2900	reviewed	Ion channel
Q16512	BXGT013631	Serine/threonine-protein kinase N1	5585	reviewed	Kinase
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16566	BXGT013639	Calcium/calmodulin-dependent protein kinase type IV	814	reviewed	Kinase
Q16595	BXGT013643	Frataxin, mitochondrial	2395	reviewed	Enzyme
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q5JTZ9	BXGT015458	Alanine--tRNA ligase, mitochondrial	57505	reviewed	Nucleic acid binding
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q6PI48	BXGT016471	Aspartate--tRNA ligase, mitochondrial	55157	reviewed	Enzyme
Q7Z2E3	BXGT017246	Aprataxin	54840	reviewed	Nucleic acid binding
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8IWQ3	BXGT018355	Serine/threonine-protein kinase BRSK2	9024	reviewed	Kinase
Q8IX04	BXGT018358	Ubiquitin-conjugating enzyme E2 variant 3	55293	reviewed	Enzyme
Q8NI60	BXGT018572	Atypical kinase COQ8A, mitochondrial	56997	reviewed	Kinase
Q8TE04	BXGT018818	Pantothenate kinase 1	53354	reviewed	Kinase
Q92796	BXGT019376	Disks large homolog 3	1741	reviewed
Q96AP4	BXGT019618	Zinc finger-containing ubiquitin peptidase 1	221302	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PR1	BXGT019710	Potassium voltage-gated channel subfamily C member 2	3747	reviewed	Ion channel
Q96Q89	BXGT019716	Kinesin-like protein KIF20B	9585	reviewed	Cellular structure
Q96T60	BXGT019745	Bifunctional polynucleotide phosphatase/kinase	11284	reviewed
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99653	BXGT019945	Calcineurin B homologous protein 1	11261	reviewed
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q9BXM7	BXGT020172	Serine/threonine-protein kinase PINK1, mitochondrial	65018	reviewed	Kinase
Q9GZZ9	BXGT020430	Ubiquitin-like modifier-activating enzyme 5	79876	reviewed	Enzyme
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9H4W6	BXGT020478	Transcription factor COE3	253738	reviewed
Q9H8P0	BXGT020497	Polyprenol reductase	79644	reviewed
Q9HCG7	BXGT020533	Non-lysosomal glucosylceramidase	57704	reviewed
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	55775	reviewed	Enzyme
Q9NW15	BXGT021229	Anoctamin-10	55129	reviewed
Q9NWX6	BXGT021238	Probable tRNA(His) guanylyltransferase	54974	reviewed
Q9NY47	BXGT021249	Voltage-dependent calcium channel subunit alpha-2/delta-2	9254	reviewed	Ion channel
Q9NYL2	BXGT021259	Mitogen-activated protein kinase kinase kinase 20	51776	reviewed	Kinase
Q9NZJ4	BXGT021274	Sacsin	26278	reviewed
Q9UGI6	BXGT021681	Small conductance calcium-activated potassium channel protein 3	3782	reviewed	Ion channel
Q9UGM6	BXGT021687	Tryptophan--tRNA ligase, mitochondrial	10352	reviewed
Q9UH99	BXGT021693	SUN domain-containing protein 2	25777	reviewed	Cellular structure
Q9UIK4	BXGT021720	Death-associated protein kinase 2	23604	reviewed	Kinase
Q9UK17	BXGT021735	Potassium voltage-gated channel subfamily D member 3	3752	reviewed	Ion channel
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UMR5	BXGT021776	Lysosomal thioesterase PPT2	9374	reviewed	Enzyme
Q9UPZ9	BXGT021804	Serine/threonine-protein kinase ICK	22858	reviewed	Kinase
Q9UQD0	BXGT021811	Sodium channel protein type 8 subunit alpha	6334	reviewed	Ion channel
Q9Y2M0	BXGT022241	Fanconi-associated nuclease 1	22909	reviewed
Q9NYP7	BXGT022661	Elongation of very long chain fatty acids protein 5	60481	reviewed	Enzyme
Q9Y5W7	BXGT022783	Sorting nexin-14	57231	reviewed	Enzyme modulator
Q7Z624	BXGT022792	Calmodulin-lysine N-methyltransferase	79823	reviewed
P09622	BXGT023116	Dihydrolipoyl dehydrogenase, mitochondrial	1738	reviewed	Enzyme
P19875	BXGT023294	C-X-C motif chemokine 2	2920	reviewed	Signaling
Q9UBP0	BXGT023601	Spastin	6683	reviewed	Cellular structure
A6NGN9	BXGT023893	IgLON family member 5	402665	reviewed
P0DP25	BXGT024595	Calmodulin-3	808	reviewed
O43583	BXGT024866	Density-regulated protein	8562	reviewed	Enzyme
Q9UNE7	BXGT025000	E3 ubiquitin-protein ligase CHIP	10273	reviewed
Q9Y4W6	BXGT025025	AFG3-like protein 2	10939	reviewed	Enzyme
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
P18858	BXGT025156	DNA ligase 1	3978	reviewed	Enzyme
Q05086	BXGT025648	Ubiquitin-protein ligase E3A	7337	reviewed
Q6IQ55	BXGT025689	Tau-tubulin kinase 2	146057	reviewed	Kinase
P35251	BXGT025853	Replication factor C subunit 1	5981	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}