Showing entry for Sprouty-related, EVH1 domain-containing protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025789
Protein NameSprouty-related, EVH1 domain-containing protein 1
Uniport IdQ7Z699
GeneSPRED1
Gene Id161742
DomainSprouty; WH1
Pfam PF05210   PF00568  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008543 fibroblast growth factor receptor signaling pathway
Biological Process GO:0000188 inactivation of MAPK activity
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Biological Process GO:0010719 negative regulation of epithelial to mesenchymal transition
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:1902747 negative regulation of lens fiber cell differentiation
Biological Process GO:0043409 negative regulation of MAPK cascade
Biological Process GO:0010801 negative regulation of peptidyl-threonine phosphorylation
Biological Process GO:0010923 negative regulation of phosphatase activity
Biological Process GO:0006469 negative regulation of protein kinase activity
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process GO:0043408 regulation of MAPK cascade
Biological Process GO:0090311 regulation of protein deacetylation
Biological Process GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
molecular function GO:0019902 phosphatase binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0030291 protein serine/threonine kinase inhibitor activity
molecular function GO:0005173 stem cell factor receptor binding
cellular component GO:0005901 caveola
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-190236 Signaling by FGFR
R-HSA-5654736 Signaling by FGFR1
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027830 BXGD002046 neurofibroma Neoplasms; Nervous System Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028326 BXGD002075 Noonan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0080024 BXGD003104 Piebaldism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0206728 BXGD004273 Plexiform Neurofibroma Neoplasms; Nervous System Diseases
C0221263 BXGD004427 Cafe-au-Lait Spots Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0265541 BXGD005545 Cranioschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0432072 BXGD008718 Dysmorphic features
C0497552 BXGD009067 Congenital neurologic anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0521525 BXGD009139 Short neck
C0553586 BXGD009401 Cafe-au-lait macules with pulmonary stenosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0745730 BXGD010132 Multiple lipomata Neoplasms
C0796000 BXGD010774 Multiple non-ossifying fibromatosis
C0856169 BXGD011096 Endothelial dysfunction
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1835884 BXGD014061 Triangular face
C1837404 BXGD014229 High, narrow palate
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1842180 BXGD014504 CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1855728 BXGD015536 Low posterior hairline
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1860335 BXGD015979 Axillary freckling Skin and Connective Tissue Diseases
C1969623 BXGD016782 NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C4025790 BXGD021791 Specific learning disability
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein