Showing entry for Idiopathic pulmonary arterial hypertension


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD018555
Disease NameIdiopathic pulmonary arterial hypertension
Disease CUI IdC3203102
MeSH Codes C08  
Disease Class NameRespiratory Tract Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0002086   HP:0001626  
Human Phenotype Ontology TermAbnormality of the respiratory system; Abnormality of the cardiovascular system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 6446 reviewed Kinase
O00238 BXGT003900 Bone morphogenetic protein receptor type-1B 658 reviewed Kinase
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00429 BXGT003919 Dynamin-1-like protein 10059 reviewed Enzyme modulator
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 1111 reviewed Kinase
O14788 BXGT004100 Tumor necrosis factor ligand superfamily member 11 8600 reviewed Signaling
O15120 BXGT004129 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 10555 reviewed
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15439 BXGT004169 Multidrug resistance-associated protein 4 10257 reviewed Transporter
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O15553 BXGT004181 Pyrin 4210 reviewed
O43255 BXGT004579 E3 ubiquitin-protein ligase SIAH2 6478 reviewed
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O43826 BXGT004629 Glucose-6-phosphate exchanger SLC37A4 2542 reviewed Transporter
O43915 BXGT004636 Vascular endothelial growth factor D 2277 reviewed Signaling
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O60858 BXGT004903 E3 ubiquitin-protein ligase TRIM13 10206 reviewed
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75116 BXGT005100 Rho-associated protein kinase 2 9475 reviewed Kinase
O75390 BXGT005123 Citrate synthase, mitochondrial 1431 reviewed Enzyme
O75460 BXGT005127 Serine/threonine-protein kinase/endoribonuclease IRE1 2081 reviewed Kinase
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
O94760 BXGT005328 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 23576 reviewed Enzyme
O95390 BXGT005377 Growth/differentiation factor 11 10220 reviewed Signaling
O95477 BXGT005383 Phospholipid-transporting ATPase ABCA1 19 reviewed Transporter
O95835 BXGT005400 Serine/threonine-protein kinase LATS1 9113 reviewed Kinase
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
O96028 BXGT005417 Histone-lysine N-methyltransferase NSD2 7468 reviewed Epigenetic regulator
P00439 BXGT005539 Phenylalanine-4-hydroxylase 5053 reviewed
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00742 BXGT005636 Coagulation factor X 2159 reviewed Enzyme
P00746 BXGT005638 Complement factor D 1675 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00750 BXGT005642 Tissue-type plasminogen activator 5327 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P00915 BXGT005689 Carbonic anhydrase 1 759 reviewed
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01042 BXGT005722 Kininogen-1 3827 reviewed Enzyme modulator
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02818 BXGT005969 Osteocalcin 632 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03886 BXGT006108 NADH-ubiquinone oxidoreductase chain 1 4535 reviewed Enzyme
P03905 BXGT006113 NADH-ubiquinone oxidoreductase chain 4 4538 reviewed Enzyme
P03915 BXGT006114 NADH-ubiquinone oxidoreductase chain 5 4540 reviewed Enzyme
P03923 BXGT006115 NADH-ubiquinone oxidoreductase chain 6 4541 reviewed
P03950 BXGT006116 Angiogenin 283 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04062 BXGT006140 Lysosomal acid glucosylceramidase 2629 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04731 BXGT006251 Metallothionein-1A 4489 reviewed
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05106 BXGT006315 Integrin beta-3 3690 reviewed Receptor
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P05556 BXGT006368 Integrin beta-1 3688 reviewed Receptor
P05787 BXGT006385 Keratin, type II cytoskeletal 8 3856 reviewed
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P06744 BXGT006494 Glucose-6-phosphate isomerase 2821 reviewed Enzyme
P06870 BXGT006518 Kallikrein-1 3816 reviewed Enzyme
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07237 BXGT006576 Protein disulfide-isomerase 5034 reviewed
P07305 BXGT006594 Histone H1.0 3005 reviewed Nucleic acid binding
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08246 BXGT006756 Neutrophil elastase 1991 reviewed Enzyme
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08397 BXGT006768 Porphobilinogen deaminase 3145 reviewed Enzyme
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08603 BXGT006798 Complement factor H 3075 reviewed
P08670 BXGT006810 Vimentin 7431 reviewed
P08758 BXGT006821 Annexin A5 308 reviewed
P08865 BXGT006832 40S ribosomal protein SA 3921 reviewed Nucleic acid binding
P08887 BXGT006835 Interleukin-6 receptor subunit alpha 3570 reviewed Signaling
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P10144 BXGT007541 Granzyme B 3002 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10599 BXGT007583 Thioredoxin 7295 reviewed
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11308 BXGT007684 Transcriptional regulator ERG 2078 reviewed Transcription factor
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 5292 reviewed Kinase
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11712 BXGT007738 Cytochrome P450 2C9 1559 reviewed
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12724 BXGT007837 Eosinophil cationic protein 6037 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src 6714 reviewed Kinase
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P13688 BXGT007943 Carcinoembryonic antigen-related cell adhesion molecule 1 634 reviewed
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14618 BXGT008027 Pyruvate kinase PKM 5315 reviewed Kinase
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15151 BXGT008089 Poliovirus receptor 5817 reviewed
P15289 BXGT008102 Arylsulfatase A 410 reviewed Enzyme
P15309 BXGT008105 Prostatic acid phosphatase 55 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16109 BXGT008194 P-selectin 6403 reviewed
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P17643 BXGT008323 5,6-dihydroxyindole-2-carboxylic acid oxidase 7306 reviewed Enzyme
P17655 BXGT008325 Calpain-2 catalytic subunit 824 reviewed Enzyme
P17861 BXGT008348 X-box-binding protein 1 7494 reviewed
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18848 BXGT008432 Cyclic AMP-dependent transcription factor ATF-4 468 reviewed
P18850 BXGT008433 Cyclic AMP-dependent transcription factor ATF-6 alpha 22926 reviewed
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19429 BXGT008479 Troponin I, cardiac muscle 7137 reviewed Cellular structure
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P20827 BXGT008606 Ephrin-A1 1942 reviewed Kinase
P21333 BXGT008638 Filamin-A 2316 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21583 BXGT008667 Kit ligand 4254 reviewed
P21709 BXGT008685 Ephrin type-A receptor 1 2041 reviewed Kinase
P21796 BXGT008690 Voltage-dependent anion-selective channel protein 1 7416 reviewed
P21817 BXGT008693 Ryanodine receptor 1 6261 reviewed Ion channel
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P22460 BXGT008774 Potassium voltage-gated channel subfamily A member 5 3741 reviewed Ion channel
P22736 BXGT008800 Nuclear receptor subfamily 4 group A member 1 3164 reviewed Nuclear receptor
P22749 BXGT008803 Granulysin 10578 reviewed
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23141 BXGT008830 Liver carboxylesterase 1 1066 reviewed Enzyme
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23297 BXGT008848 Protein S100-A1 6271 reviewed Calcium-binding protein
P23786 BXGT008906 Carnitine O-palmitoyltransferase 2, mitochondrial 1376 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24530 BXGT008975 Endothelin receptor type B 1910 reviewed G-protein coupled receptor
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P25440 BXGT009044 Bromodomain-containing protein 2 6046 reviewed Epigenetic regulator
P25705 BXGT009060 ATP synthase subunit alpha, mitochondrial 498 reviewed Transporter
P25774 BXGT009066 Cathepsin S 1520 reviewed Enzyme
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28222 BXGT009238 5-hydroxytryptamine receptor 1B 3351 reviewed G-protein coupled receptor
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29218 BXGT009322 Inositol monophosphatase 1 3612 reviewed Enzyme
P29320 BXGT009332 Ephrin type-A receptor 3 2042 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29460 BXGT009348 Interleukin-12 subunit beta 3593 reviewed Signaling
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30279 BXGT009415 G1/S-specific cyclin-D2 894 reviewed Enzyme modulator
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31946 BXGT009588 14-3-3 protein beta/alpha 7529 reviewed Chaperone
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35414 BXGT009829 Apelin receptor 187 reviewed G-protein coupled receptor
P35475 BXGT009837 Alpha-L-iduronidase 3425 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 2324 reviewed Kinase
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36551 BXGT009927 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 1371 reviewed Enzyme
P36894 BXGT009939 Bone morphogenetic protein receptor type-1A 657 reviewed Kinase
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37023 BXGT009953 Serine/threonine-protein kinase receptor R3 94 reviewed Kinase
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38435 BXGT010040 Vitamin K-dependent gamma-carboxylase 2677 reviewed
P38571 BXGT010054 Lysosomal acid lipase/cholesteryl ester hydrolase 3988 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P39060 BXGT010088 Collagen alpha-1(XVIII) chain 80781 reviewed
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P41182 BXGT010231 B-cell lymphoma 6 protein 604 reviewed
P41595 BXGT010267 5-hydroxytryptamine receptor 2B 3357 reviewed G-protein coupled receptor
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42226 BXGT010288 Signal transducer and activator of transcription 6 6778 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42702 BXGT010335 Leukemia inhibitory factor receptor 3977 reviewed Signaling
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase 10135 reviewed Signaling
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46934 BXGT010553 E3 ubiquitin-protein ligase NEDD4 4734 reviewed Enzyme
P46939 BXGT010555 Utrophin 7402 reviewed
P47712 BXGT010577 Cytosolic phospholipase A2 5321 reviewed Enzyme
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49023 BXGT010672 Paxillin 5829 reviewed Cellular structure
P49116 BXGT010678 Nuclear receptor subfamily 2 group C member 2 7182 reviewed Nuclear receptor
P49419 BXGT010705 Alpha-aminoadipic semialdehyde dehydrogenase 501 reviewed Enzyme
P49450 BXGT010710 Histone H3-like centromeric protein A 1058 reviewed
P49585 BXGT010712 Choline-phosphate cytidylyltransferase A 5130 reviewed
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49840 BXGT010749 Glycogen synthase kinase-3 alpha 2931 reviewed Kinase
P49888 BXGT010756 Estrogen sulfotransferase 6783 reviewed
P49902 BXGT010758 Cytosolic purine 5'-nucleotidase 22978 reviewed Enzyme
P49908 BXGT010760 Selenoprotein P 6414 reviewed Extracellular structure
P49913 BXGT010761 Cathelicidin antimicrobial peptide 820 reviewed
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P50416 BXGT010797 Carnitine O-palmitoyltransferase 1, liver isoform 1374 reviewed Enzyme
P50579 BXGT010812 Methionine aminopeptidase 2 10988 reviewed
P51575 BXGT010861 P2X purinoceptor 1 5023 reviewed Ion channel
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P53985 BXGT011022 Monocarboxylate transporter 1 6566 reviewed Transporter
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P54750 BXGT011072 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5136 reviewed
P55957 BXGT011137 BH3-interacting domain death agonist 637 reviewed
P56524 BXGT011176 Histone deacetylase 4 9759 reviewed Epigenetic regulator
P58004 BXGT011222 Sestrin-2 83667 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61586 BXGT011375 Transforming protein RhoA 387 reviewed Enzyme modulator
P61587 BXGT011376 Rho-related GTP-binding protein RhoE 390 reviewed Enzyme modulator
P62314 BXGT011420 Small nuclear ribonucleoprotein Sm D1 6632 reviewed Nucleic acid binding
P62736 BXGT011452 Actin, aortic smooth muscle 59 reviewed Cellular structure
P62937 BXGT011471 Peptidyl-prolyl cis-trans isomerase A 5478 reviewed
P63165 BXGT011506 Small ubiquitin-related modifier 1 7341 reviewed
P63244 BXGT011510 Receptor of activated protein C kinase 1 10399 reviewed
P63261 BXGT011512 Actin, cytoplasmic 2 71 reviewed Cellular structure
P68871 BXGT011615 Hemoglobin subunit beta 3043 reviewed
P69892 BXGT011647 Hemoglobin subunit gamma-2 3048 reviewed
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P81172 BXGT011935 Hepcidin 57817 reviewed
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D 776 reviewed Ion channel
Q02083 BXGT012633 N-acylethanolamine-hydrolyzing acid amidase 27163 reviewed Enzyme
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta 5467 reviewed Nuclear receptor
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q05586 BXGT012826 Glutamate receptor ionotropic, NMDA 1 2902 reviewed Ion channel
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06830 BXGT012894 Peroxiredoxin-1 5052 reviewed Enzyme
Q07837 BXGT012943 Neutral and basic amino acid transport protein rBAT 6519 reviewed Transporter
Q07954 BXGT012950 Prolow-density lipoprotein receptor-related protein 1 4035 reviewed
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q08722 BXGT013002 Leukocyte surface antigen CD47 961 reviewed
Q09428 BXGT013036 ATP-binding cassette sub-family C member 8 6833 reviewed Transporter
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13464 BXGT013357 Rho-associated protein kinase 1 6093 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13873 BXGT013398 Bone morphogenetic protein receptor type-2 659 reviewed Kinase
Q14108 BXGT013440 Lysosome membrane protein 2 950 reviewed Receptor
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14289 BXGT013459 Protein-tyrosine kinase 2-beta 2185 reviewed Kinase
Q14571 BXGT013485 Inositol 1,4,5-trisphosphate receptor type 2 3709 reviewed Ion channel
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 5163 reviewed Kinase
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15717 BXGT013589 ELAV-like protein 1 1994 reviewed
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q15811 BXGT013600 Intersectin-1 6453 reviewed Enzyme modulator
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q16647 BXGT013648 Prostacyclin synthase 5740 reviewed
Q16654 BXGT013650 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 5166 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16678 BXGT013656 Cytochrome P450 1B1 1545 reviewed Enzyme
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q16875 BXGT013686 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 5209 reviewed Kinase
Q32MK0 BXGT014323 Myosin light chain kinase 3 91807 reviewed Kinase
Q6NUK1 BXGT016429 Calcium-binding mitochondrial carrier protein SCaMC-1 29957 reviewed Transporter
Q76LX8 BXGT016870 A disintegrin and metalloproteinase with thrombospondin motifs 13 11093 reviewed Enzyme
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q86TU7 BXGT017608 Actin-histidine N-methyltransferase 84193 reviewed
Q8IVS2 BXGT018349 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial 27349 reviewed
Q8NE86 BXGT018552 Calcium uniporter protein, mitochondrial 90550 reviewed Ion channel
Q8NEB9 BXGT018553 Phosphatidylinositol 3-kinase catalytic subunit type 3 5289 reviewed Kinase
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q8NET8 BXGT018557 Transient receptor potential cation channel subfamily V member 3 162514 reviewed Ion channel
Q8TDS5 BXGT018813 Oxoeicosanoid receptor 1 165140 reviewed G-protein coupled receptor
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 151306 reviewed G-protein coupled receptor
Q8TDV0 BXGT018815 Probable G-protein coupled receptor 151 134391 reviewed G-protein coupled receptor
Q92547 BXGT019355 DNA topoisomerase 2-binding protein 1 11073 reviewed
Q92993 BXGT019403 Histone acetyltransferase KAT5 10524 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96IY4 BXGT019678 Carboxypeptidase B2 1361 reviewed Enzyme
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q99572 BXGT019935 P2X purinoceptor 7 5027 reviewed Ion channel
Q99683 BXGT019947 Mitogen-activated protein kinase kinase kinase 5 4217 reviewed Kinase
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 2034 reviewed Transcription factor
Q9BYF1 BXGT020186 Angiotensin-converting enzyme 2 59272 reviewed Enzyme
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9HBA0 BXGT020516 Transient receptor potential cation channel subfamily V member 4 59341 reviewed Ion channel
Q9HC29 BXGT020526 Nucleotide-binding oligomerization domain-containing protein 2 64127 reviewed Enzyme
Q9HCE7 BXGT020532 E3 ubiquitin-protein ligase SMURF1 57154 reviewed Enzyme
Q9NPC2 BXGT021150 Potassium channel subfamily K member 9 51305 reviewed Ion channel
Q9NPH5 BXGT021159 NADPH oxidase 4 50507 reviewed Enzyme
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 23410 reviewed Epigenetic regulator
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9P246 BXGT021298 Stromal interaction molecule 2 57620 reviewed
Q9P2K8 BXGT021302 eIF-2-alpha kinase GCN2 440275 reviewed
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UIK4 BXGT021720 Death-associated protein kinase 2 23604 reviewed Kinase
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9ULV1 BXGT021764 Frizzled-4 8322 reviewed G-protein coupled receptor
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UQL6 BXGT021813 Histone deacetylase 5 10014 reviewed Epigenetic regulator
Q9Y234 BXGT022211 Lipoyltransferase 1, mitochondrial 51601 reviewed Enzyme
Q9Y3D6 BXGT022257 Mitochondrial fission 1 protein 51024 reviewed
Q9Y3Z3 BXGT022268 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 25939 reviewed
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y4U1 BXGT022285 Methylmalonic aciduria and homocystinuria type C protein 25974 reviewed
Q9Y5S8 BXGT022302 NADPH oxidase 1 27035 reviewed
Q9Y5X0 BXGT022305 Sorting nexin-10 29887 reviewed
Q9Y6K9 BXGT022333 NF-kappa-B essential modulator 8517 reviewed Kinase
Q01995 BXGT022678 Transgelin 6876 reviewed Cellular structure
Q9NQG6 BXGT022733 Mitochondrial dynamics protein MID51 54471 reviewed
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q9UK05 BXGT023094 Growth/differentiation factor 2 2658 reviewed Signaling
P17752 BXGT023118 Tryptophan 5-hydroxylase 1 7166 reviewed
Q01543 BXGT023137 Friend leukemia integration 1 transcription factor 2313 reviewed Transcription factor
Q9GZQ8 BXGT023414 Microtubule-associated proteins 1A/1B light chain 3B 81631 reviewed Cellular structure
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
O15198 BXGT024049 Mothers against decapentaplegic homolog 9 4093 reviewed Transcription factor
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
P63167 BXGT024120 Dynein light chain 1, cytoplasmic 8655 reviewed Cellular structure
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
O95399 BXGT024237 Urotensin-2 10911 reviewed
P08123 BXGT024477 Collagen alpha-2(I) chain 1278 reviewed
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
P16104 BXGT024571 Histone H2AX 3014 reviewed Nucleic acid binding
O43583 BXGT024866 Density-regulated protein 8562 reviewed Enzyme
Q12888 BXGT024878 TP53-binding protein 1 7158 reviewed Epigenetic regulator
Q8IZA0 BXGT025026 Dyslexia-associated protein KIAA0319-like protein 79932 reviewed
O14649 BXGT025486 Potassium channel subfamily K member 3 3777 reviewed Ion channel
P19474 BXGT025520 E3 ubiquitin-protein ligase TRIM21 6737 reviewed
Q9H1K1 BXGT025766 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial 23479 reviewed
Q7Z699 BXGT025789 Sprouty-related, EVH1 domain-containing protein 1 161742 reviewed Receptor
P51798 BXGT026083 H(+)/Cl(-) exchange transporter 7 1186 reviewed Ion channel
Q8N122 BXGT026091 Regulatory-associated protein of mTOR 57521 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease