Showing entry for Oxoglaucine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000164
Compound NameOxoglaucine
Structure
FormulaC20H17NO5
InchiKeyZYKCETVKVRJFGD-UHFFFAOYSA-N
SMILESCOC1=CC2=C(C=C1OC)C1=C(OC)C(OC)=CC3=C1C(=NC=C3)C2=O
InchiInChI=1S/C20H17NO5/c1-23-13-8-11-12(9-14(13)24-2)19(22)18-16-10(5-6-21-18)7-15(25-3)20(26-4)17(11)16/h5-9H,1-4H3
IUPAC4,5,15,16-tetramethoxy-10-azatetracyclo[7.7.1.02,?.013,1?]heptadeca-1(16),2(7),3,5,9,11,13(17),14-octaen-8-one
Molecular Weight351.35
Pubchem Id97662
Chembl IdCHEMBL470881
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 52491
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT022194 Zinc finger protein mex-5 reviewed mex-5 - - - 834
CHEMBL CHEMBL470881
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 12589 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 5173 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 39810 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 4109 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 1000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 3349 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 7943 nM
P42858 BXGT010341 Huntingtin reviewed - HTT Potency '=' 1778 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 15848 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 3548 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 12589 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 3162 nM
Q92793 BXGT019374 CREB-binding protein reviewed - CREBBP Potency '=' 3162 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 6309 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 8199 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 8912 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 2511 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 3548 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 8912 nM
Q9XUB2 BXGT022194 Zinc finger protein mex-5 reviewed - mex-5 EC50 '=' 834 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 22387 nM
Q92793 BXGT019374 CREB-binding protein reviewed - CREBBP Potency '=' 1000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 4217 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 25118 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 7943 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 22387 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 4109 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 12589 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 3539 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 14125 nM
G5EF15 BXGT003524 Cytoplasmic zinc-finger protein unreviewed - pos-1 EC50 '=' 68553 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 1995 nM
Q92793 BXGT019374 CREB-binding protein reviewed - CREBBP Potency '=' 158 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 7079 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 10000 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 100000 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 31622 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 7079 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 39810 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '>' 20000 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Activity '=' 64 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 15848 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '>' 20000 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 19952 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Activity '=' 89 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00301 Cherimoya Annona cherimola Fruits
BXGF00446 Sugar apple Annona squamosa Fruits
BXGF00822 Beverages Beverages
BXGF00823 Fruits Fruits
BXGF01060 Baccharis grandicapitulata Baccharis grandicapitulata Others
BXGF01079 Renealmia alpinia Renealmia alpinia Human Edible Plant
BXGF01207 Morella pensylvanica Morella pensylvanica Others
BXGF01276 Delphinium giraldii Delphinium giraldii Medicinal Plant
BXGF01337 Stellaria media Stellaria media Medicinal Plant
BXGF01461 Liriodendron tulipifera Liriodendron tulipifera Medicinal Plant
BXGF01493 Curcuma aeruginosa Curcuma aeruginosa Medicinal Plant
BXGF01603 Piper brachystachyum Piper brachystachyum Medicinal Plant
BXGF01688 Tephroseris kirilowii Tephroseris kirilowii Medicinal Plant
BXGF01731 Corydalis turtschaninovii Corydalis turtschaninovii Human Edible Plant
BXGF01967 Senecio congestus Senecio congestus Medicinal Plant
BXGF02081 Glaucium oxylobum Glaucium oxylobum Others
BXGF02124 Papaver pseudocanescens Papaver pseudocanescens Others
BXGF02242 Sideritis dasygnaphala Sideritis dasygnaphala Others
BXGF02265 Xylopia aethiopica Xylopia aethiopica Medicinal Plant
BXGF02382 Gutierrezia dracunculoides Gutierrezia dracunculoides Others
BXGF02423 Psidium acutangulum Psidium acutangulum Human Edible Plant
BXGF02440 Beesia calthifolia Beesia calthifolia Others
BXGF02483 Bursera kerberi Bursera kerberi Others
BXGF02514 Helenium integrifolium Helenium integrifolium Others
BXGF02543 Rhododendron mucronulatum Rhododendron mucronulatum Medicinal Plant
BXGF02570 Euonymus fortunei Euonymus fortunei Medicinal Plant
BXGF02613 Phlomis crinita Phlomis crinita Medicinal Plant
BXGF02665 Crotalaria stolzii Crotalaria stolzii Others
BXGF02682 Selinum libanotis Selinum libanotis Others
BXGF02718 Melampodium leucanthum Melampodium leucanthum Others
BXGF02734 Clerodendrum trichotomum Clerodendrum trichotomum Medicinal Plant
BXGF02750 Juniperus scopulorum Juniperus scopulorum Medicinal Plant
BXGF02785 Clinacanthus nutans Clinacanthus nutans Medicinal Plant
BXGF02827 Alstonia angustiloba Alstonia angustiloba Others
BXGF02840 Lasianthaea podocephala Lasianthaea podocephala Others
BXGF02855 Eucalyptus albens Eucalyptus albens Others
BXGF02908 Pellacalyx axillaris Pellacalyx axillaris Others
BXGF02950 Boschniakia rossica Boschniakia rossica Medicinal Plant
BXGF03368 Gelsemium elegans Gelsemium elegans Medicinal Plant
BXGF03817 Coffea liberica var. dewevrei Coffea liberica var. dewevrei Medicinal Plant
BXGF04006 Corydalis ternata Corydalis ternata Others
BXGF04011 Botrychium ternatum Botrychium ternatum Medicinal Plant
BXGF04902 Lupinus cosentinii Lupinus cosentinii Others
BXGF04912 Corydalis rhizoma Corydalis rhizoma Others
BXGF05318 Hedysarum gmelini Hedysarum gmelini Others
BXGF05465 Euploca racemosa Euploca racemosa Others
BXGF05994 Corydalis yanhusuo Corydalis yanhusuo Medicinal Plant
BXGF06271 Artemisia pectinata Artemisia pectinata Others
BXGF06307 Zephyranthes flava Zephyranthes flava Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease