Showing entry for Lethal factor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008169
Protein NameLethal factor
Uniport IdP15917
Genelef
Gene Id3361711;45025515
DomainAnthrax-tox_M; ATLF
Pfam PF09156   PF07737  
OrganismBacillus anthracis
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0043409 negative regulation of MAPK cascade
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0009405 pathogenesis
Biological Process GO:0044533 positive regulation of apoptotic process in other organism
Biological Process GO:0006508 proteolysis
Biological Process GO:0035897 proteolysis in other organism
Biological Process GO:1903140 regulation of establishment of endothelial barrier
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
molecular function GO:0046872 metal ion binding
molecular function GO:0008237 metallopeptidase activity
molecular function GO:0090729 toxin activity
cellular component GO:0005576 extracellular region
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5339562 Uptake and actions of bacterial toxins
R-HSA-5663205 Infectious disease
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000164 Oxoglaucine 351.35
BXGC0000194 Sanguinarine 332.33
BXGC0000204 Theophylline 180.16
BXGC0000288 L-Proline 115.13
BXGC0000340 Kaempferol 286.24
BXGC0000368 Gallic acid 170.12
BXGC0000383 (S)-Naringenin 272.25
BXGC0000430 Gossypol 518.55
BXGC0000436 Glycerol 92.09
BXGC0000500 2,4-Dihydroxybenzoic acid 154.12
BXGC0000502 Gentisic acid 154.12
BXGC0000503 2,6-Dihydroxybenzoic acid 154.12
BXGC0000505 Protocatechuic acid 154.12
BXGC0000528 Salicylic acid 138.12
BXGC0000530 Hydroquinone 110.11
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000563 1H-Indole-3-methanol 147.17
BXGC0000655 Harmalol 200.24
BXGC0000679 Palmidrol 299.49
BXGC0000952 6-Oxocamphor 457.91
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0001426 (S)-Isocorydine 341.4
BXGC0001502 Caffeine 194.19
BXGC0001544 Harmaline 214.26
BXGC0001615 (E)-Zeatin 219.24
BXGC0001626 3-Aminopropanoic acid 89.09
BXGC0001630 Arginine 174.2
BXGC0001789 Silibinin 482.44
BXGC0001842 Bergapten 216.19
BXGC0001995 Maltol 126.11
BXGC0002011 Isoeugenol 164.2
BXGC0002052 Aesculetin 178.14
BXGC0002144 Tetradecanoic acid 228.37
BXGC0003066 Phenols 199.27
BXGC0003218 Foluene 92.14
BXGC0003396 Legumelin 394.42
BXGC0003647 Ethyl linilenate 306.49
BXGC0003705 Chloride 35.45
BXGC0003707 Estrogen 268.36
BXGC0003894 Phospholipase 343.36
BXGC0004197 Isopentyl acetate 130.18
BXGC0004280 2,4-Pentanedione 100.12
BXGC0004284 Hexanedioic acid 146.14
BXGC0004285 Agmatine 130.19
BXGC0004560 Benzoic acid 122.12
BXGC0004576 2-tert-Butyl-1,4-benzenediol 166.22
BXGC0004709 N-(2-Hydroxybenzoyl)glycine 195.17
BXGC0004764 (R)-Octopamine 153.18
BXGC0004955 N-Phenyl-2-naphthylamine 219.28
BXGC0005030 2-Acetylthiazole 127.16
BXGC0005053 3-Hydroxy-2H-pyran-2-one 112.08
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005624 Genistein 270.24
BXGC0005668 2-Methoxyphenol 124.14
BXGC0005793 Baicalein 270.24
BXGC0005869 Riboflavine 376.36
BXGC0005881 Urea 60.06
BXGC0005898 2,3-Dihydroxybenzoic acid 154.12
BXGC0005915 Formononetin 268.27
BXGC0005935 3,4',7-Trihydroxyflavone 270.24
BXGC0005982 Curcumin 368.38
BXGC0006057 (Z)-Resveratrol 228.25
BXGC0006073 Capsaicin 305.41
BXGC0006115 Xanthotoxin 216.19
BXGC0006186 L-Aspartic acid 133.1
BXGC0006193 Ellagic acid 302.19
BXGC0006213 Psoralen 186.17
BXGC0006291 Scopoletin 192.17
BXGC0006306 Myricetin 318.24
BXGC0006389 Rotenone 394.42
BXGC0006635 Luteolin 286.24
BXGC0007014 Harman 182.22
BXGC0007028 beta-Thujaplicin 164.2
BXGC0007029 Emodin 270.24
BXGC0007052 Olomoucine 298.34
BXGC0007524 3-(Dimethylaminomethyl)indole 174.24
BXGC0007560 alpha-Mangostin 410.46
BXGC0007675 Pyridine 79.1
BXGC0008184 Phloretin 274.27
BXGC0009409 7-Methyl-3-methylene-1,6-octadiene 136.24
BXGC0009649 Dihydrocapsaicin 307.43
BXGC0012352 Chelerythrine 348.12
BXGC0013359 (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid 180.04
BXGC0014454 Beta-Peltatin A 414.13
BXGC0014602 Kojic Acid 142.03
BXGC0015080 6,7-Dimethoxy-2-Methyl-3,4-Dihydroisoquinolin-1-One 221.11
BXGC0015236 (6R)-6-[(5R)-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl]-6H-Furo[3,4-G][1,3]Benzodioxol-8-One 367.11
BXGC0015594 4-Nonylphenol 220.18
BXGC0015879 Chlorhexidine 504.2
BXGC0016468 (2S)-2-Hydroxy-2-(4-Hydroxy-3-Methoxyphenyl)Acetic Acid 198.05
BXGC0016470 Camptothecin 348.11
BXGC0017515 (R)-Pinocembrin 256.07
BXGC0018073 2-Phenylethyl (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoate 284.1
BXGC0018165 Cyclopentanes 70.08
BXGC0018252 Embelin 294.18
BXGC0018772 Pseudoephedrine 165.12
BXGC0019164 Raloxifene 473.17
BXGC0020024 Lawsone 174.03
BXGC0021237 (-)-Usnic Acid 344.09
BXGC0021831 Spartioidine 333.16
BXGC0021931 [(1S,5R)-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl] (2R)-3-Hydroxy-2-Phenylpropanoate 289.17
BXGC0022449 Vitamin B2 376.14
BXGC0022544 Digoxin 780.43
BXGC0022978 Biphenyl-4-Amine 169.09
BXGC0023872 Adenine 135.05
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024915 Dehydroglaucine 353.16
BXGC0025017 Bergamottin 338.15
BXGC0025485 Transtorine 189.04
BXGC0026249 Naramycin B 281.16
BXGC0026802 2,4-Dimethylphenol 122.07
BXGC0027421 Paclitaxel 853.33
BXGC0027480 (2E,4E)-Deca-2,4-Dienal 152.12
BXGC0027735 [(5R,5Ar,8Ar,9R)-8-Oxo-9-(3,4,5-Trimethoxyphenyl)-5A,6,8A,9-Tetrahydro-5H-[2]Benzofuro[5,6-F][1,3]Benzodioxol-5-Yl] Acetate 456.14
BXGC0028696 Cichoric Acid 474.08
BXGC0028981 Serine 105.04
BXGC0029291 Diphyllin 380.09
BXGC0030138 Colchicine 399.17
BXGC0030714 Daphnoretin 352.06
BXGC0030815 (S)-Verapamil 454.28
BXGC0031068 2,5-Dimethylfuran 96.06
BXGC0031622 Podofilox 414.13
BXGC0032684 Pyrene 202.08
BXGC0033776 Cycloheximide 281.16
BXGC0033797 3-hydroxypicolinic acid 139.03
BXGC0034006 Fluoranthene 202.08
BXGC0034077 (2Z,4Z)-5-(1,3-Benzodioxol-5-Yl)-1-Piperidin-1-Ylpenta-2,4-Dien-1-One 285.14
BXGC0036362 Sodium Lauryl Sulfate 265.15
BXGC0036476 D-Glutamate 147.05
BXGC0036605 pyromeconic acid 112.02
BXGC0037152 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 516.18
BXGC0037224 Dichloroacetic Acid 127.94
BXGC0037666 Retinal 284.21
BXGC0037718 Ethacrynic Acid 302.01
BXGC0037722 Pomiferin 420.16
BXGC0037954 Pimaric Acid 302.22
BXGC0038329 iodoform 393.72
BXGC0038466 Tuberostemonine 375.24
BXGC0039019 Harmol 198.08
BXGC0039046 Digitonin 1228.57
BXGC0039350 Gs-39783 337.16
BXGC0039684 Berberine Chloride 336.12
BXGC0040228 4'-Demethyldeoxypodophyllotoxin 384.12
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0040528 2-Picolinic Acid 123.03
BXGC0041054 Bis(2-Ethylhexyl) Phthalate 390.28
BXGC0041195 Boldine 327.15
BXGC0041560 Thiram 239.99
BXGC0042127 Oxyquinoline 145.05
BXGC0042231 Pyridine-2,3-Diol 111.03
BXGC0042252 Homoharringtonine 545.26
BXGC0042270 acetohydroxamic acid 75.03
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042562 Acrylamide 71.04
BXGC0042626 Pyrrole-2-Carboxylic Acid 111.03
BXGC0043126 Nicardipine 479.21
BXGC0043230 Glabranin 324.14
BXGC0043639 1-Tert-Butyl-2-Methoxy-4-Methyl-3,5-Dinitrobenzene 268.11
BXGC0044200 Menadione 172.05
BXGC0044637 1400W 177.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0045746 Diphenyleneiodonium 278.97
BXGC0045812 Trifluoperazine 407.16
BXGC0046510 Tpck 351.07
BXGC0046737 Berbamine 608.29
BXGC0047086 4-[(2R)-2-[(1R,3R,5S)-3,5-Dimethyl-2-Oxocyclohexyl]-2-Hydroxyethyl]Piperidine-2,6-Dione 281.16
BXGC0047127 Hydron;2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline;Chloride 355.18
BXGC0047867 Dalfampridine 94.05
BXGC0048244 1H-Quinolin-2-One 145.05
BXGC0049397 Olvanil 417.32
BXGC0049633 4-Aminophenol 109.05
BXGC0049926 Conessine 356.32
BXGC0050044 Hydrastine 383.14
BXGC0050599 tetrandrine 622.3
BXGC0050854 Ricinine 164.06
BXGC0051013 N-Phenylnaphthalen-1-Amine 219.1
BXGC0051864 Aristolochic Acid 341.05
BXGC0052374 Reserpine 608.27
BXGC0053235 Fraxetin 208.04
BXGC0053629 Esatenolol 266.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein