Showing entry for Guanine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0002912
Compound NameGuanine
Structure
FormulaC5H5N5O
InchiKeyUYTPUPDQBNUYGX-UHFFFAOYSA-N
SMILESNC1=NC(=O)C2=C(N1)N=CN2
InchiInChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
IUPAC2-amino-6,7-dihydro-3H-purin-6-one
Molecular Weight151.13
Pubchem Id135398634
Chembl IdCHEMBL219568
Targets of Information Source
DrugBank DB02377
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q9X1T2 BXGT022112 Purine nucleoside phosphorylase unreviewed - TM_1596 experimental -
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP experimental -
P45563 BXGT010469 Purine nucleoside phosphorylase 2 reviewed - xapA experimental -
P0A9M5 BXGT007194 Xanthine phosphoribosyltransferase reviewed - gpt experimental -
P30793 BXGT009466 GTP cyclohydrolase 1 reviewed Enzyme GCH1 experimental inhibitor
PDB GUN
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P0A9M5 BXGT007194 Xanthine phosphoribosyltransferase reviewed gpt - - - - -
P10297 BXGT007555 Antiviral protein I reviewed PAP1 - - - - -
O58843 BXGT004817 tRNA-guanine(15) transglycosylase reviewed tgtA - - - - -
Q9SF23 BXGT021583 Dihydroneopterin aldolase 1 reviewed FOLB1 - - - - -
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed PNP Enzyme - - - -
Q9X1T2 BXGT022112 Purine nucleoside phosphorylase unreviewed TM_1596 - - - - -
P0ACP7 BXGT007269 HTH-type transcriptional repressor PurR reviewed purR - - - - -
Q03629 BXGT012731 Uncharacterized protein YML079W reviewed YML079W - - - - -
Q00511 BXGT012529 Uricase reviewed uaZ - - - - -
P45563 BXGT010469 Purine nucleoside phosphorylase 2 reviewed xapA - - - - -
Q97MB6 BXGT019812 Cytosine/guanine deaminase related protein unreviewed CA_C0282 - - - - -
Q65751 BXGT016141 Leucine zipper protein unreviewed VP4 - - - - -
P07132 BXGT006555 Core protein VP4 reviewed Segment-4 - - - - -
A1L259 BXGT001022 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase reviewed urad - - - - -
Q89NG0 BXGT017745 Guanine deaminase unreviewed blr3880 - - - - -
P28720 BXGT009288 Queuine tRNA-ribosyltransferase reviewed tgt - - - - -
Q9KTK0 BXGT020999 NADPH-dependent 7-cyano-7-deazaguanine reductase reviewed queF - - - - -
D9J2T9 BXGT003028 Ribosome inactivating protein unreviewed RIP - - - - -
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed XDH - - - - -
O55236 BXGT004749 mRNA-capping enzyme reviewed Rngtt - - - - -
Q2T1V0 BXGT014206 Dihydroneopterin aldolase unreviewed BTH_I0291 - - - - -
Q0PA35 BXGT013127 Bifunctional protein FolD reviewed folD - - - - -
Q8V635 BXGT024163 Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virio unreviewed - - - - -
Q936X6 BXGT025222 Bmp domain-containing protein unreviewed orf97 - - - 110 -
Q936X6 BXGT025222 Bmp domain-containing protein unreviewed orf97 - - - - -
P04632 BXGT006241 Calpain small subunit 1 reviewed CAPNS1 - - - - -
P0A6X3 BXGT007078 RNA-binding protein Hfq reviewed hfq - - - - -
Binding DB 50200094
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012080 Purine nucleoside phosphorylase reviewed Pnp 5000 - - -
reviewed BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP 5000 - - -
reviewed BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP - 5000 - -
reviewed BXGT005982 Ricin reviewed - - 900000 - -
reviewed BXGT011128 Purine nucleoside phosphorylase reviewed PNP - - 160 -
reviewed BXGT011128 Purine nucleoside phosphorylase reviewed PNP - - 120 -
CHEMBL CHEMBL219568
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9FBI2 BXGT020357 Shiga toxin subunit A reviewed - stxA Inhibition - - -
P55859 BXGT011128 Purine nucleoside phosphorylase reviewed - PNP Kd '=' 3300 nM
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP Ki '=' 5000 nM
Q9FBI2 BXGT020357 Shiga toxin subunit A reviewed - stxA IC50 '=' 11500 nM
Q9FBI2 BXGT020357 Shiga toxin subunit A reviewed - stxA Delta Tm '=' 4 degrees C
P02879 BXGT005982 Ricin reviewed - IC50 '=' 900000 nM
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase reviewed Enzyme HPRT1 Km '=' 1900 nM
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP IC50 '=' 5000 nM
P55859 BXGT011128 Purine nucleoside phosphorylase reviewed - PNP Kd '=' 120 nM
Q9Y2T3 BXGT022246 Guanine deaminase reviewed Enzyme GDA Km '=' 11210 nM
P26281 BXGT009097 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase reviewed - folK Kd '=' 38000 nM
P85973 BXGT012080 Purine nucleoside phosphorylase reviewed - Pnp Ratio '=' 3 -
P85973 BXGT012080 Purine nucleoside phosphorylase reviewed - Pnp Ki '=' 5000 nM
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP Inhibition '=' 80 %
P55859 BXGT011128 Purine nucleoside phosphorylase reviewed - PNP Kd '=' 160 nM
P26281 BXGT009097 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase reviewed - folK Inhibition '=' 48 %
P55859 BXGT011128 Purine nucleoside phosphorylase reviewed - PNP Kieq '=' 4000 nM
Q9FBI2 BXGT020357 Shiga toxin subunit A reviewed - stxA Activity - - -
Q9FBI2 BXGT020357 Shiga toxin subunit A reviewed - stxA Inhibition '=' 88 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00022 Oat Avena sativa Cereals and cereal products
BXGF00125 Rice Oryza sativa Cereals and cereal products
BXGF00150 Guava Psidium guajava Fruits
BXGF00187 Common wheat Triticum aestivum Cereals and cereal products
BXGF00246 Red beetroot Beta vulgaris var. rubra Vegetables
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF01093 Fritillaria pallidiflora Fritillaria pallidiflora Medicinal Plant
BXGF01347 Fritillaria delavayi Fritillaria delavayi Medicinal Plant
BXGF01413 Fritillaria verticillata Fritillaria verticillata Medicinal Plant
BXGF01479 Fritillaria cirrhosa Fritillaria cirrhosa Medicinal Plant
BXGF01776 Fritillaria prezewalskii Fritillaria prezewalskii Others
BXGF01913 Fritillaria unibracteata Fritillaria unibracteata Medicinal Plant
BXGF02725 Fritillaria walujewii Fritillaria walujewii Medicinal Plant
BXGF03439 Fritillaria przewalskii Fritillaria przewalskii Medicinal Plant
BXGF04103 Fritillaria taipaiensis Fritillaria taipaiensis Others
BXGF05281 Fritillaria thunbergii Fritillaria thunbergii Medicinal Plant
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF05505 Fritillaria ussuriensis Fritillaria ussuriensis Medicinal Plant
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease