Showing entry for Lipoxygenase


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0003397
Compound NameLipoxygenase
Structure
FormulaC10H10F3N3
InchiKeyCPXGGWXJNQSFEP-UHFFFAOYSA-N
SMILESNC1=NN(CC1)C1=CC=CC(=C1)C(F)(F)F
InchiInChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
IUPAC1-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine
Molecular Weight229.2
Pubchem Id47795
Chembl IdCHEMBL274642
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50000540
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 7600 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 5800 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 5000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 1300 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 13000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 2000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 750 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 5600 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 97000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 4900 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - 213000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 12000 - -
reviewed BXGT016082 Prostaglandin G/H synthase 1 reviewed Ptgs1 - 800 - -
reviewed BXGT011858 Prostaglandin G/H synthase 2 reviewed PTGS2 - 1300 - -
reviewed BXGT016082 Prostaglandin G/H synthase 1 reviewed Ptgs1 - 6000 - -
reviewed BXGT016082 Prostaglandin G/H synthase 1 reviewed Ptgs1 - 5000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - - - 30
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 12000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 1000 - -
reviewed BXGT006137 Phospholipase A2 reviewed Pla2g1b - >25000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 890 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 3000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - - - 6800
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 20000 - -
CHEMBL CHEMBL274642
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Inhibition - - -
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 2000 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 6000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 6000 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 5000 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Inhibition '=' 5 %
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 EC50 '=' 6800 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 890 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 Change '=' 10 uM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 12000 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 7600 nM
P04055 BXGT006137 Phospholipase A2 reviewed - Pla2g1b IC50 '>' 25000 nM
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 1300 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 1300 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 ED50 '>' 300 mg.kg-1
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 Change '=' 11 uM
O62698 BXGT004925 Prostaglandin G/H synthase 2 reviewed - PTGS2 COI '=' 30 %
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 EC50 '=' 30 mg kg-1
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 3000 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 18 %
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 Change '=' 4 uM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Change '=' 4 uM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 Change '=' 8 uM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Change '=' 8 uM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 12000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 12000 nM
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Activity - - -
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 1300 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 1000 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 5600 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 97000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 97000 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 20000 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 5000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 5000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 213000 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 750 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 13000 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 5800 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 5800 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 4900 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 800 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 800 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00085 Soy bean Glycine max Soy
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease