Showing entry for Arachidonate 5-lipoxygenase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007824
Protein NameArachidonate 5-lipoxygenase
Uniport IdP12527
GeneAlox5
Gene Id25290
DomainLipoxygenase; PLAT
Pfam PF00305   PF01477  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0036336 dendritic cell migration
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0051122 hepoxilin biosynthetic process
Biological Process GO:0006959 humoral immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0002232 leukocyte chemotaxis involved in inflammatory response
Biological Process GO:0002523 leukocyte migration involved in inflammatory response
Biological Process GO:1901753 leukotriene A4 biosynthetic process
Biological Process GO:0019370 leukotriene biosynthetic process
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:0002540 leukotriene production involved in inflammatory response
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0034440 lipid oxidation
Biological Process GO:2001301 lipoxin biosynthetic process
Biological Process GO:0019372 lipoxygenase pathway
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0001937 negative regulation of endothelial cell proliferation
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:1903573 negative regulation of response to endoplasmic reticulum stress
Biological Process GO:1903671 negative regulation of sprouting angiogenesis
Biological Process GO:0061044 negative regulation of vascular wound healing
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:1904960 positive regulation of cytochrome-c oxidase activity
Biological Process GO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:1900407 regulation of cellular response to oxidative stress
Biological Process GO:1900015 regulation of cytokine production involved in inflammatory response
Biological Process GO:0045598 regulation of fat cell differentiation
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0106014 regulation of inflammatory response to wounding
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:1903426 regulation of reactive oxygen species biosynthetic process
Biological Process GO:0055093 response to hyperoxia
Biological Process GO:0007584 response to nutrient
Biological Process GO:0019233 sensory perception of pain
molecular function GO:0004051 arachidonate 5-lipoxygenase activity
molecular function GO:0016787 hydrolase activity
molecular function GO:0005506 iron ion binding
molecular function GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0005635 nuclear envelope
cellular component GO:0005641 nuclear envelope lumen
cellular component GO:0016363 nuclear matrix
cellular component GO:0031965 nuclear membrane
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0042383 sarcolemma
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000016 Butein 272.25
BXGC0000070 Caffeic acid ethyl ester 208.21
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000470 Chalconaringenin 272.25
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000663 Papain 206.28
BXGC0001857 Caffeic acid 180.16
BXGC0002043 Acacetin 284.26
BXGC0003066 Phenols 199.27
BXGC0003397 Lipoxygenase 229.2
BXGC0003485 Naphthalen-1-ol 144.17
BXGC0003810 Cirsilion 330.29
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0008707 Isoliquiritigenin 256.25
BXGC0017077 Campneoside I 654.22
BXGC0022781 Echinacoside 786.26
BXGC0025876 Acetoside 624.21
BXGC0028680 Zerumbone 218.17
BXGC0031724 2-Methylnaphthalen-1-Ol 158.07
BXGC0038051 Calythropsin 286.08
BXGC0039787 2',4'-Dihydroxychalcone 240.08
BXGC0040344 Forsythoside B 756.25
BXGC0042448 cylindol A 318.07
BXGC0045254 Sb-202190 331.11
BXGC0045863 n.a 590.2
BXGC0045871 n.a 736.26
BXGC0046200 Crocetin Monogentibiosyl Ester 652.27
BXGC0046244 n.a 740.22
BXGC0049858 Chalcone 208.09
BXGC0052325 Calceolarioside A 478.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein