acompound

Showing entry for Uracil

General Compound Information
BXGC Id	BXGC0003675
Compound Name	Uracil
Structure
Formula	C4H4N2O2
InchiKey	ISAKRJDGNUQOIC-UHFFFAOYSA-N
SMILES	O=C1NC=CC(=O)N1
Inchi	InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
IUPAC	1,2,3,4-tetrahydropyrimidine-2,4-dione
Molecular Weight	112.09
Pubchem Id	1174
Chembl Id	CHEMBL566

Targets of Information Source

DrugBank

DB03419

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P0AA43	BXGT007206	Ribosomal small subunit pseudouridine synthase A	reviewed	-	rsuA	experimental; investigational	-
P10186	BXGT007545	Uracil-DNA glycosylase	reviewed	-	UL2	experimental; investigational	-
Q8X444	BXGT019036	Uracil-DNA glycosylase	reviewed	-	ung	experimental; investigational	-
Q12882	BXGT013276	Dihydropyrimidine dehydrogenase [NADP(+)]	reviewed	Enzyme	DPYD	experimental; investigational	-
Q9NWZ5	BXGT021240	Uridine-cytidine kinase-like 1	reviewed	Kinase	UCKL1	experimental; investigational	-
Q5SKC5	BXGT015766	Type-4 uracil-DNA glycosylase	reviewed	-	udg	experimental; investigational	-
P77836	BXGT011823	Pyrimidine-nucleoside phosphorylase	reviewed	-	pdp	experimental; investigational	-

PDB

URA

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Q26998	BXGT013924	Uracil phosphoribosyltransferase	reviewed	uprt	-	-	-	-	-
P77836	BXGT011823	Pyrimidine-nucleoside phosphorylase	reviewed	pdp	-	-	-	-	-
P13051	BXGT007877	Uracil-DNA glycosylase	reviewed	UNG	-	-	-	-	-
P12295	BXGT007792	Uracil-DNA glycosylase	reviewed	ung	-	-	-	-	-
Q28943	BXGT013956	Dihydropyrimidine dehydrogenase [NADP(+)]	reviewed	DPYD	-	-	-	-	-
P0AA43	BXGT007206	Ribosomal small subunit pseudouridine synthase A	reviewed	rsuA	-	-	-	-	-
Q9YGN6	BXGT022383	Single-strand selective monofunctional uracil DNA glycosylase	reviewed	smug1	-	-	-	-	-
P12758	BXGT007845	Uridine phosphorylase	reviewed	udp	-	-	-	-	-
P23540	BXGT008881	Ribonuclease MC	reviewed		-	-	-	-	-
P10186	BXGT007545	Uracil-DNA glycosylase	reviewed	UL2	-	-	-	-	-
Q5SKC5	BXGT015766	Type-4 uracil-DNA glycosylase	reviewed	udg	-	88	-	-	-
Q00511	BXGT012529	Uricase	reviewed	uaZ	-	-	-	-	-
P0A1F6	BXGT006985	Uridine phosphorylase	reviewed	udp	-	-	-	-	-
O95045	BXGT005344	Uridine phosphorylase 2	reviewed	UPP2	Enzyme	-	-	-	-
Q57VZ2	BXGT015159	Nucleoside phosphorylase, putative	unreviewed	Tb927.8.4430	-	-	-	-	-
D0VWU0	BXGT002730	Uracil-DNA glycosylase	unreviewed		-	-	-	-	-
A5PJH9	BXGT001350	Uridine phosphorylase	unreviewed	UPP1	-	-	-	-	-
P0ACU2	BXGT007274	HTH-type transcriptional regulator RutR	reviewed	rutR	-	-	-	-	-
Q9KT71	BXGT020996	Uridine phosphorylase	unreviewed	VC_1034	-	-	-	-	-
P0AGM7	BXGT007379	Uracil permease	reviewed	uraA	-	-	-	-	-
Q5XA29	BXGT015907	Uridine phosphorylase	unreviewed	M6_Spy1599	-	-	-	-	-
Q81P86	BXGT017355	Aminoglycoside N(3)-acetyltransferase	unreviewed	aacC7	-	-	-	-	-
G3J531	BXGT003478	Uracil-5-carboxylate decarboxylase	unreviewed	CCM_01452	-	-	-	-	-
D9J2T9	BXGT003028	Ribosome inactivating protein	unreviewed	RIP	-	-	-	-	-
Q91UM2	BXGT019299	Uracil-DNA glycosylase	reviewed	UNG	-	-	-	-	-
Q9K4U1	BXGT020874	Uridine phosphorylase	unreviewed	udp	-	-	-	-	-
G4VGI0	BXGT003512	Putative uridine phosphorylase	reviewed	UPPA	-	-	-	-	-
P9WFQ9	BXGT012247	Uracil-DNA glycosylase	reviewed	ung	-	-	-	-	-
P20536	BXGT008581	Uracil-DNA glycosylase	reviewed	UNG	-	-	-	-	-
Q8E9X9	BXGT018079	Uridine phosphorylase	unreviewed	udp	-	-	-	-	-
Q96YD0	BXGT019761	Type-4 uracil-DNA glycosylase	reviewed	STK_22380	-	-	-	-	-
Q89XR0	BXGT017749	Blr0248 protein	unreviewed	blr0248	-	-	-	-	-
P75898	BXGT011760	Pyrimidine monooxygenase RutA	reviewed	rutA	-	-	-	-	-
P0AGM8	BXGT007380	Uracil permease	reviewed	uraA	-	-	-	-	-
A0QP43	BXGT023728	Uracil DNA glycosylase superfamily protein	unreviewed	MSMEG_0265	-	-	-	-	-
I7F541	BXGT024359	Type-4 uracil-DNA glycosylase	unreviewed	MSMEI_0259	-	-	-	-	-
A0A410UCT3	BXGT024581	Uridine phosphorylase	unreviewed	up	-	-	-	-	-

Binding DB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM

CHEMBL

CHEMBL566

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	3162	nM
Q13148	BXGT013318	TAR DNA-binding protein 43	reviewed	-	TARDBP	Potency	-	35481	nM
O42713	BXGT004563	Polyphenol oxidase 2	reviewed	-	PPO2	Inhibition	-	-	-

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00042	Safflower	Carthamus tinctorius	Herbs and Spices
BXGF00063	Saffron	Crocus sativus	Herbs and Spices
BXGF00125	Rice	Oryza sativa	Cereals and cereal products
BXGF00187	Common wheat	Triticum aestivum	Cereals and cereal products
BXGF00205	Corn	Zea mays	Cereals and cereal products
BXGF00212	Chinese chives	Allium tuberosum	Herbs and Spices
BXGF00337	Ginkgo nuts	Ginkgo biloba	Herbs and Spices
BXGF00522	Narrowleaf cattail	Typha angustifolia	Vegetables
BXGF01093	Fritillaria pallidiflora	Fritillaria pallidiflora	Medicinal Plant
BXGF01185	Aloe vera	Aloe vera	Medicinal Plant
BXGF01323	Pinellia pedatisecta	Pinellia pedatisecta	Medicinal Plant
BXGF01347	Fritillaria delavayi	Fritillaria delavayi	Medicinal Plant
BXGF01413	Fritillaria verticillata	Fritillaria verticillata	Medicinal Plant
BXGF01479	Fritillaria cirrhosa	Fritillaria cirrhosa	Medicinal Plant
BXGF01776	Fritillaria prezewalskii	Fritillaria prezewalskii	Others
BXGF01787	Cotyledon fimbriata turcz	Cotyledon fimbriata turcz	Others
BXGF01885	Aconitum triphyllum	Aconitum triphyllum	Others
BXGF01900	Aloe ferox	Aloe ferox	Medicinal Plant
BXGF01913	Fritillaria unibracteata	Fritillaria unibracteata	Medicinal Plant
BXGF02049	Angelica sinensis	Angelica sinensis	Medicinal Plant
BXGF02725	Fritillaria walujewii	Fritillaria walujewii	Medicinal Plant
BXGF02847	Podocarpus elongata	Podocarpus elongata	Others
BXGF03078	Chrysanthemum x morifolium	Chrysanthemum x morifolium	Medicinal Plant
BXGF03348	Panax notoginseng	Panax notoginseng	Medicinal Plant
BXGF03432	Chrysanthemum indicum	Chrysanthemum indicum	Medicinal Plant
BXGF03439	Fritillaria przewalskii	Fritillaria przewalskii	Medicinal Plant
BXGF03444	Gastrodia elata	Gastrodia elata	Medicinal Plant
BXGF03919	Xanthium strumarium	Xanthium strumarium	Medicinal Plant
BXGF04103	Fritillaria taipaiensis	Fritillaria taipaiensis	Others
BXGF04600	Typha orientalis	Typha orientalis	Medicinal Plant
BXGF04631	Aloe spicata	Aloe spicata	Medicinal Plant
BXGF04680	Eschweilera coriacea	Eschweilera coriacea	Human Edible Plant
BXGF04889	Pogostemon cablin	Pogostemon cablin	Medicinal Plant
BXGF04920	Aconitum carmichaeli	Aconitum carmichaeli	Medicinal Plant
BXGF04926	Aloe africana	Aloe africana	Medicinal Plant
BXGF05159	Eucalyptus cladocalyx	Eucalyptus cladocalyx	Medicinal Plant
BXGF05281	Fritillaria thunbergii	Fritillaria thunbergii	Medicinal Plant
BXGF05330	Arum ternatum thunb	Arum ternatum thunb	Others
BXGF05360	Aconitum ciliare	Aconitum ciliare	Others
BXGF05365	Aconitum carmichaelii	Aconitum carmichaelii	Medicinal Plant
BXGF05505	Fritillaria ussuriensis	Fritillaria ussuriensis	Medicinal Plant
BXGF05510	Ulva pertusa	Ulva pertusa	Medicinal Plant
BXGF05571	Ziziphus jujuba	Ziziphus jujuba	Medicinal Plant
BXGF05576	Lagotis brevituba	Lagotis brevituba	Others
BXGF05688	Salvadora persica	Salvadora persica	Medicinal Plant
BXGF05722	Hedysarum polybotrys	Hedysarum polybotrys	Medicinal Plant
BXGF05851	Aconitum japonicum	Aconitum japonicum	Medicinal Plant
BXGF05915	Fritillaria hupehensis	Fritillaria hupehensis	Medicinal Plant
BXGF06106	Aconitum kusnezoffii	Aconitum kusnezoffii	Others
BXGF06268	Zanthoxylum nitidum	Zanthoxylum nitidum	Medicinal Plant
BXGF06321	Peltodon longipes	Peltodon longipes	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}