Showing entry for Uracil-DNA glycosylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007877
Protein NameUracil-DNA glycosylase
Uniport IdP13051
GeneUNG
Gene Id7374
DomainUDG
Pfam PF03167  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
6. Human Diseases 6.3 Immune diseases hsa05340 Primary immunodeficiency
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006284 base-excision repair
Biological Process GO:0097510 base-excision repair, AP site formation via deaminated base removal
Biological Process GO:0045008 depyrimidination
Biological Process GO:0006281 DNA repair
Biological Process GO:0045190 isotype switching
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0016446 somatic hypermutation of immunoglobulin genes
Biological Process GO:0016032 viral process
molecular function GO:0003684 damaged DNA binding
molecular function GO:0043024 ribosomal small subunit binding
molecular function GO:0004844 uracil DNA N-glycosylase activity
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010418 BXGD000671 Cryptosporidiosis Digestive System Diseases; Infections; Animal Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0014534 BXGD000924 Epididymitis Male Urogenital Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028084 BXGD002071 Nightmares
C0035369 BXGD002543 Retroviridae Infections Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0266999 BXGD005725 Vesicular Stomatitis Infections; Stomatognathic Diseases; Animal Diseases
C0272236 BXGD006327 Hyperimmunoglobulin M syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398689 BXGD008216 Hyper-IgM Immunodeficiency Syndrome, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0497169 BXGD009054 hiv-infection/aids Infections
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1720956 BXGD013695 Hyper-IgM Immunodeficiency Syndrome, Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1720957 BXGD013696 Hyper-IgM Immunodeficiency Syndrome, Type 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1720958 BXGD013697 Hyper-IgM Immunodeficiency Syndrome, Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1842528 BXGD014521 Impaired Ig class switch recombination
C1842777 BXGD014537 Recurrent upper and lower respiratory tract infections
C1844383 BXGD014628 Recurrent bacterial infection Infections
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3887605 BXGD019902 Nightmare Disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003675 Uracil 112.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein