Showing entry for TAR DNA-binding protein 43


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013318
Protein NameTAR DNA-binding protein 43
Uniport IdQ13148
GeneTARDBP
Gene Id23435
DomainRRM_1; TDP43_N
Pfam PF00076   PF18694  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061158 3'-UTR-mediated mRNA destabilization
Biological Process GO:0070935 3'-UTR-mediated mRNA stabilization
Biological Process GO:0006397 mRNA processing
Biological Process GO:0043922 negative regulation by host of viral transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0071765 nuclear inner membrane organization
Biological Process GO:0032024 positive regulation of insulin secretion
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0048511 rhythmic process
Biological Process GO:0008380 RNA splicing
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0042802 identical protein binding
molecular function GO:0003730 mRNA 3'-UTR binding
molecular function GO:0097157 pre-mRNA intronic binding
molecular function GO:0003723 RNA binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0035061 interchromatin granule
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005726 perichromatin fibrils
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003635 BXGD000214 Apraxias Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017075 BXGD001089 Ganglioneuroma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0023066 BXGD001605 Laryngospasm Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023827 BXGD001707 liposarcoma Neoplasms
C0024408 BXGD001768 Machado-Joseph Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0024517 BXGD001780 Major depression, single episode Mental Disorders
C0025202 BXGD001832 melanoma Neoplasms
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026884 BXGD001945 Mutism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027813 BXGD002041 Neuritis Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0027877 BXGD002055 Neuronal Ceroid-Lipofuscinoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034935 BXGD002497 Babinski Reflex
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0043352 BXGD003045 Xerostomia Stomatognathic Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085220 BXGD003142 Cerebral Amyloid Angiopathy Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085655 BXGD003226 Polymyositis Musculoskeletal Diseases; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0154682 BXGD003731 Lateral Sclerosis Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205858 BXGD004135 General Paralysis Infections; Nervous System Diseases
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0221014 BXGD004364 Reactive systemic amyloidosis Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0221166 BXGD004397 Paraparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234133 BXGD004624 Extrapyramidal sign
C0234410 BXGD004665 Physiologic disinhibition
C0234958 BXGD004702 Muscle degeneration Musculoskeletal Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0238190 BXGD004890 Inclusion Body Myositis (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0241816 BXGD005115 Global brain atrophy
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0264733 BXGD005422 Ventricular dilatation (disorder) Cardiovascular Diseases
C0265218 BXGD005467 Neu-Laxova syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0268279 BXGD005881 Lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270726 BXGD006093 Alexander Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0270763 BXGD006099 Familial Motor Neuron Disease Nervous System Diseases
C0270790 BXGD006105 Quadriparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270952 BXGD006139 Muscular Dystrophy, Oculopharyngeal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278608 BXGD006549 Adult Liposarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279984 BXGD006703 Childhood Liposarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282513 BXGD006808 Primary Progressive Aphasia (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0334583 BXGD007124 Pilocytic Astrocytoma Neoplasms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338460 BXGD007179 Argyrophilic grain disease
C0338462 BXGD007180 Semantic Dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349217 BXGD007894 Depressive episode, unspecified Mental Disorders; Behavior and Behavior Mechanisms
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393554 BXGD008087 Amyotrophic Lateral Sclerosis With Dementia Nutritional and Metabolic Diseases; Nervous System Diseases
C0393570 BXGD008093 Corticobasal degeneration Nervous System Diseases
C0406778 BXGD008372 Dermatopathia pigmentosa reticularis Pathological Conditions, Signs and Symptoms; Neoplasms; Skin and Connective Tissue Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424296 BXGD008525 Social disinhibition Mental Disorders
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426980 BXGD008599 Motor symptoms
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520716 BXGD009103 Pallidopontonigral degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0521175 BXGD009134 Neuropil Threads
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0543859 BXGD009298 Amyotrophic Lateral Sclerosis, Guam Form Nutritional and Metabolic Diseases; Nervous System Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700635 BXGD009897 Strudwick syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751706 BXGD010559 Primary Progressive Nonfluent Aphasia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751713 BXGD010564 Inclusion Body Myopathy, Sporadic Musculoskeletal Diseases; Nervous System Diseases
C0751783 BXGD010592 Lafora Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0796274 BXGD010828 Brown-Vialetto-Van Laere Syndrome 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0869474 BXGD011306 Dyscalculia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0878486 BXGD011364 Arteriolosclerosis Cardiovascular Diseases
C0917981 BXGD011423 Progressive Muscular Atrophy Nervous System Diseases
C0948379 BXGD011533 Impaired insulin secretion
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C0973461 BXGD011595 Dysphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1389113 BXGD012965 Generalized amyotrophy
C1504404 BXGD013141 Hippocampal sclerosis
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1720037 BXGD013665 Supranuclear gaze palsy
C1833662 BXGD013936 INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders
C1838681 BXGD014337 Rapidly progressive
C1839780 BXGD014405 FRAGILE X TREMOR/ATAXIA SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1843792 BXGD014606 FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED
C1846566 BXGD014829 Degeneration of the lateral corticospinal tracts
C1849485 BXGD015057 Neuronal loss in the cerebral cortex
C1849722 BXGD015081 Polyglucosan Body Disease, Adult Form Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1853723 BXGD015354 MYOPATHY, DISTAL 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Nervous System Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C1861736 BXGD016072 SPINOCEREBELLAR ATAXIA 31 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1865412 BXGD016326 Abnormal lower motor neuron morphology
C1867773 BXGD016471 CEREBRAL AMYLOID ANGIOPATHY, ITM2B-RELATED, 1
C1868594 BXGD016511 Perry Syndrome Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C1883018 BXGD016594 Severe Aplastic Anemia Hemic and Lymphatic Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C2677565 BXGD017377 AMYOTROPHIC LATERAL SCLEROSIS 10 (disorder)
C2678065 BXGD017398 Myofibrillar Myopathy Musculoskeletal Diseases; Nervous System Diseases
C2718017 BXGD017522 TDP-43 Proteinopathies Nutritional and Metabolic Diseases; Nervous System Diseases
C2750737 BXGD017675 DIARRHEA 5, WITH TUFTING ENTEROPATHY, CONGENITAL Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Nutritional and Metabolic Diseases
C2931784 BXGD018062 Amyloid angiopathy Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C3148872 BXGD018272 FRONTOTEMPORAL DEMENTIA WITH TDP43 INCLUSIONS, TARDBP-RELATED
C3150169 BXGD018295 FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED
C3150171 BXGD018296 FTLD-TDP, TARDBP-RELATED
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3502417 BXGD019045 Amyotrophic Lateral Sclerosis 10 Nutritional and Metabolic Diseases; Nervous System Diseases
C3536715 BXGD019070 AA amyloidosis Nutritional and Metabolic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C3811918 BXGD019664 GRN-related frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C3887938 BXGD019929 Deuteranomaly Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3888102 BXGD019952 Frontotemporal Dementia With Motor Neuron Disease Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C4011788 BXGD020116 Behavioral variant of frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C4014650 BXGD020156 Abnormal mitochondrial morphology
C4020732 BXGD020474 Mitochondrial abnormalities
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4022588 BXGD020929 Fatigable weakness of swallowing muscles
C4024896 BXGD021461 Motor neuron atrophy
C4025723 BXGD021757 Abnormal upper motor neuron morphology
C4082299 BXGD022088 Bulbar palsy Nervous System Diseases
C4082769 BXGD022094 Chronic Traumatic Encephalopathy Nervous System Diseases; Wounds and Injuries
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4274665 BXGD022355 Logopenic progressive aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4285807 BXGD022455 Behavioral and psychological symptoms of dementia
C4302404 BXGD022541 Non-amnestic Alzheimer disease Nervous System Diseases; Mental Disorders
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551583 BXGD023361 Cerebral cortical atrophy
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551777 BXGD023410 Brown-Vialetto-Van Laere syndrome Nervous System Diseases
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000204 Theophylline 180.16
BXGC0000388 Nobiletin 402.39
BXGC0000478 2,4,6-Tribromophenol 330.8
BXGC0000521 (+)-Asarinin 354.35
BXGC0000651 Harmalan 184.24
BXGC0000663 Papain 206.28
BXGC0001076 4-Hydroxyderricin 338.4
BXGC0001077 Xanthoangelol D 354.4
BXGC0001079 Xanthoangelol 392.49
BXGC0001080 Xanthoangelol B 408.49
BXGC0001127 3'-Dimethylallylkievitone 424.49
BXGC0001325 Progesterone 314.46
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0001428 Piperlongine 317.34
BXGC0001429 (E,E)-Piperlonguminine 273.33
BXGC0001476 Girinimbine 263.33
BXGC0001515 Cinchonidine 294.39
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001733 Tangeritin 372.37
BXGC0001779 Tetramethylscutellarein 342.34
BXGC0001823 Morusinol 438.47
BXGC0001954 trans-p-Methoxycinnamic acid 178.18
BXGC0002043 Acacetin 284.26
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002445 Nonanoic acid 158.24
BXGC0002781 Flavonoids 224.25
BXGC0002789 Isoimperatorin 270.28
BXGC0002796 Nicotine 162.23
BXGC0002801 Phellopterin 300.31
BXGC0002830 Sarkosin 89.09
BXGC0002906 Caffeic acid ester 284.31
BXGC0002971 alpha-Lipoic acid 206.33
BXGC0003255 Lochnocarpol A 408.49
BXGC0003456 1,4-Benzoquinone 108.09
BXGC0003457 alpha-Allocryptopine 369.41
BXGC0003675 Uracil 112.09
BXGC0003678 Sphondin 216.19
BXGC0003707 Estrogen 268.36
BXGC0003852 Nigrin B 506.47
BXGC0004132 Zosimin 328.36
BXGC0004187 D-Malic acid 134.09
BXGC0004199 2-Methylbutanoic acid 102.13
BXGC0004353 Thiamine hydrochloride 337.27
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0004738 Myo-Inositol 180.16
BXGC0004955 N-Phenyl-2-naphthylamine 219.28
BXGC0004999 Benzothiazole 135.19
BXGC0005017 4,7-Dihydroxy-2H-1-benzopyran-2-one 178.14
BXGC0005654 Naringin 580.53
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005800 Piperanine 287.35
BXGC0005852 Xanthoxyletin 258.27
BXGC0005894 Azelaic acid 188.22
BXGC0005908 7-Methoxy-2-methylisoflavone 266.29
BXGC0005917 Genistin 432.38
BXGC0005919 Biochanin A 284.27
BXGC0005981 (S)-4',5,7-Trihydroxy-8-prenylflavanone 340.38
BXGC0005982 Curcumin 368.38
BXGC0005989 Auraptene 298.38
BXGC0006115 Xanthotoxin 216.19
BXGC0006259 Isopimpinellin 246.22
BXGC0006326 Imperatorin 270.28
BXGC0006362 Estrone 270.37
BXGC0007028 beta-Thujaplicin 164.2
BXGC0008169 5,7-Dimethylchrysin 282.29
BXGC0008181 Morusin 420.45
BXGC0009332 Pelanin 356.5
BXGC0009984 Pyrafoline D 347.45
BXGC0009993 (R)-Mahanine 347.45
BXGC0010010 3,8''-Biapigenin 538.46
BXGC0012496 13-epi-sclareol 308.27
BXGC0013115 Psoromic Acid 358.07
BXGC0013582 Curcumin 368.13
BXGC0014059 2-Methoxy-1,4-Naphthoquinone 188.05
BXGC0014947 Glabridin 324.14
BXGC0015031 Diethyl Phthalate 222.09
BXGC0015208 Getiacaulein 288.06
BXGC0015314 1-(2,6-Dihydroxyphenyl)Dodecan-1-One 292.2
BXGC0015879 Chlorhexidine 504.2
BXGC0016028 Castanospermine 189.1
BXGC0016444 Asarinin 354.11
BXGC0016567 (E)-1-(4-Nitrophenyl)-3-Thiophen-2-Ylprop-2-En-1-One 259.03
BXGC0016725 sphaeropsidin C 332.2
BXGC0017003 Decursin 328.13
BXGC0017757 Androstenedione 286.19
BXGC0018071 Totarol 286.23
BXGC0018403 Hydroxyprogesterone 330.22
BXGC0018948 perillyl alcohol 152.12
BXGC0020381 N-Phenylpropionamide 149.08
BXGC0020385 atraric acid 196.07
BXGC0020756 4-(1,3-Benzothiazol-2-Yl)-2-Methylaniline 240.07
BXGC0020800 Testosterone 288.21
BXGC0021134 (S)(+)Carvone 150.1
BXGC0021180 1-Oxo-2H-Isoquinoline-4-Carboxylic Acid 189.04
BXGC0021255 4-[(3S)-8,8-Dimethyl-3,4-Dihydro-2H-Pyrano[2,3-F]Chromen-3-Yl]Benzene-1,3-Diol 324.14
BXGC0021553 Perillic Acid 166.1
BXGC0021600 Ilepcimide 259.12
BXGC0021766 sesamin 354.11
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
BXGC0022231 Ursodiol 392.29
BXGC0022310 Sesamin 354.11
BXGC0022806 1-(5-Thiophen-2-Ylthiophen-2-Yl)Ethanone 208
BXGC0023497 Pterostilbene 256.11
BXGC0023754 4',7-Dimethoxyisoflavone 282.09
BXGC0023872 Adenine 135.05
BXGC0024086 Gomisin M2 386.17
BXGC0024208 3-(3,4-Dimethoxyphenyl)-7-Methoxychromen-4-One 312.1
BXGC0024331 7-O-Ac-afromosin 340.09
BXGC0024813 Demethoxycurcumin 338.12
BXGC0024929 Visnagin 230.06
BXGC0025757 Calcimycin 523.27
BXGC0025887 5-Hydroxyflavone 238.06
BXGC0025979 Alisol B 472.36
BXGC0026109 Nelumol A 346.21
BXGC0026480 Osajin 404.16
BXGC0026935 Triclosan 287.95
BXGC0026943 Toxyloxanthone C 328.09
BXGC0027063 Rocaglamide 505.21
BXGC0027639 sanggenon A 436.15
BXGC0028278 Rutaecarpine 287.11
BXGC0028710 Kokusaginine 259.08
BXGC0029585 Biochanin A, Dimethyl Ether 312.1
BXGC0029807 Anisocoumarin H 314.15
BXGC0030164 cudraxanthone H 380.16
BXGC0030197 Prostaglandin B1 336.23
BXGC0030321 Isophthalic Acid 166.03
BXGC0030690 Savinin 352.09
BXGC0030696 2,3-Dimethoxyxanthen-9-One 256.07
BXGC0030879 Mesodihydroguaiaretic Acid 330.18
BXGC0031040 Atrazine 215.09
BXGC0031090 Kazinol B 392.2
BXGC0031109 2-Prop-1-En-2-Yl-2,3-Dihydrofuro[3,2-G]Chromen-7-One 228.08
BXGC0031326 Paxilline 435.24
BXGC0031717 Purpurin 256.04
BXGC0031881 4-methoxy-5-hydroxycanthin-6-one 266.07
BXGC0033130 Benzoin 212.08
BXGC0033179 Daphneolon 270.13
BXGC0033776 Cycloheximide 281.16
BXGC0033960 3-Hydroxybenzo[C]Chromen-6-One 212.05
BXGC0034576 2-(4-Hydroxyphenyl)Ethyl 4-Methoxybenzoate 272.1
BXGC0034673 selinidin 328.13
BXGC0034778 Artemisinin 282.15
BXGC0035364 MLS002703042 548.26
BXGC0035575 6-(2-Methylbut-3-En-2-Yl)Furo[3,2-G]Chromen-7-One 254.09
BXGC0036632 Austrobailignan 6 328.17
BXGC0037722 Pomiferin 420.16
BXGC0038066 Rescinnamine 634.29
BXGC0038322 Kavain 230.09
BXGC0038486 (2S)-3-[(2S,3S)-5,7-Dihydroxy-2-(4-Methoxyphenyl)-4-Oxo-2,3-Dihydrochromen-3-Yl]-5,7-Dihydroxy-2-(4-Methoxyphenyl)-2,3-Dihydrochromen-4-One 570.15
BXGC0038577 Magnolol 266.13
BXGC0039172 Oxyresveratrol 244.07
BXGC0039270 4-Amino-1H-Imidazole-5-Carboxamide 126.05
BXGC0039397 Athraquinones A 240.04
BXGC0039807 Nootkatin 232.15
BXGC0040492 (3R)-8-Hydroxy-3-(4-Hydroxyphenyl)-3,4-Dihydroisochromen-1-One 256.07
BXGC0040779 Gerontoxanthone I 396.16
BXGC0041240 Atenolol 266.16
BXGC0041560 Thiram 239.99
BXGC0041896 (2R,3R,4R)-2-(Hydroxymethyl)Pyrrolidine-3,4-Diol 133.07
BXGC0042105 Verrucarin A 502.22
BXGC0042211 4-Octylphenol 206.17
BXGC0042237 Ecdysterone 480.31
BXGC0042240 3-(Furan-3-Yl)-3A,7-Dimethyl-3,4,5,6-Tetrahydro-2-Benzofuran-1-One 232.11
BXGC0042253 Dihydrojasmonic Acid, Methyl Ester 226.16
BXGC0042414 2-[(E)-2-Phenylethenyl]-2,3-Dihydropyran-6-One 200.08
BXGC0042546 5-Hydroxy-2-(4-Hydroxyphenyl)-7-Methoxy-2,3-Dihydrochromen-4-One 286.08
BXGC0043055 Palmatine Chloride 352.15
BXGC0043462 medicarpin 270.09
BXGC0043578 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One 266.09
BXGC0044200 Menadione 172.05
BXGC0044388 artemisinine 282.15
BXGC0044857 Sp-600125 220.06
BXGC0046510 Tpck 351.07
BXGC0046964 Deacetylgedunin 440.22
BXGC0047086 4-[(2R)-2-[(1R,3R,5S)-3,5-Dimethyl-2-Oxocyclohexyl]-2-Hydroxyethyl]Piperidine-2,6-Dione 281.16
BXGC0048801 Sid24823998 254.09
BXGC0049447 acetate 59.01
BXGC0049521 4-Propoxybenzoic Acid 180.08
BXGC0049738 Dexibuprofen 206.13
BXGC0050880 Cudraflavone B 420.16
BXGC0051982 Mannitol 182.08
BXGC0052330 Xanthoxylol 356.13
BXGC0052948 Tanshinone I 276.08
BXGC0053274 4-(2,3-Dihydroxy-3-Methylbutoxy)Furo[3,2-G]Chromen-7-One 304.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein