acompound

Showing entry for 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether

General Compound Information
BXGC Id	BXGC0008973
Compound Name	6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether
Structure
Formula	C19H18O7
InchiKey	QEWSAPKRFOFQIU-UHFFFAOYSA-N
SMILES	COC1=C(OC)C=C(C=C1)C1=CC(=O)C2=C(O)C(OC)=C(OC)C=C2O1
Inchi	InChI=1S/C19H18O7/c1-22-12-6-5-10(7-14(12)23-2)13-8-11(20)17-15(26-13)9-16(24-3)19(25-4)18(17)21/h5-9,21H,1-4H3
IUPAC	2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-chromen-4-one
Molecular Weight	358.34
Pubchem Id	152430
Chembl Id	CHEMBL226508

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50092614

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT010223	Delta-type opioid receptor	reviewed	G-protein coupled receptor	OPRD1	3100	-	-	-

CHEMBL

CHEMBL226508

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P41145	BXGT010225	Kappa-type opioid receptor	reviewed	G-protein coupled receptor	OPRK1	Activity	'='	7	%
Q07014	BXGT012913	Tyrosine-protein kinase Lyn	reviewed	-	Lyn	Activity	-	-	-
P21708	BXGT008684	Mitogen-activated protein kinase 3	reviewed	-	Mapk3	Activity	-	-	-
P63086	BXGT011494	Mitogen-activated protein kinase 1	reviewed	-	Mapk1	Activity	-	-	-
P49185	BXGT010682	Mitogen-activated protein kinase 8	reviewed	-	Mapk8	Activity	-	-	-
P41143	BXGT010223	Delta-type opioid receptor	reviewed	G-protein coupled receptor	OPRD1	Ki	'='	3100	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	IC50	'='	900	nM
P10686	BXGT007601	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	reviewed	-	Plcg1	Activity	-	-	-
Q64725	BXGT016130	Tyrosine-protein kinase SYK	reviewed	-	Syk	Activity	-	-	-
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	Inhibition	'='	7	%
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	IC50	'>'	10000	nM
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Activity	'='	4	%
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	Ki	'='	780	nM
P35372	BXGT009823	Mu-type opioid receptor	reviewed	G-protein coupled receptor	OPRM1	Activity	'='	9	%
P21554	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	Activity	'='	3	%
P41143	BXGT010223	Delta-type opioid receptor	reviewed	G-protein coupled receptor	OPRD1	Activity	'='	86	%
P41143	BXGT010223	Delta-type opioid receptor	reviewed	G-protein coupled receptor	OPRD1	Activity	'='	32	%
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	IC50	'>'	10000	nM
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	Inhibition	'='	96	%
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	IC50	'>'	10000	nM
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	Inhibition	'='	80	%
Q16678	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	Inhibition	'='	70	%
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Inhibition	'='	9	%
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	Inhibition	'='	5	%
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	IC50	'='	1380	nM
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	Ki	'='	1420	nM
Q16678	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	IC50	'='	2500	nM
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	Inhibition	'='	13	%
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	IC50	'>'	10000	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	Inhibition	'='	90	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00056	Mandarin orange (Clementine, Tangerine)	Citrus reticulata	Fruits
BXGF00075	Black crowberry	Empetrum nigrum	Fruits
BXGF00111	Cornmint	Mentha arvensis	Herbs and Spices
BXGF00112	Spearmint	Mentha spicata	Herbs and Spices
BXGF00125	Rice	Oryza sativa	Cereals and cereal products
BXGF00165	Common sage	Salvia officinalis	Herbs and Spices
BXGF00168	Winter savory	Satureja montana	Herbs and Spices
BXGF00868	Clusia torresii	Clusia torresii	Others
BXGF00891	Artabotrys uncinatus	Artabotrys uncinatus	Others
BXGF00905	Scrophularia leucoclada	Scrophularia leucoclada	Others
BXGF00917	Rauvolfia tetraphylla	Rauvolfia tetraphylla	Medicinal Plant
BXGF01037	Ferula assa-foetida	Ferula assa-foetida	Medicinal Plant
BXGF01075	Arnebia decumbens	Arnebia decumbens	Others
BXGF01094	Asplenium nidus	Asplenium nidus	Human Edible Plant
BXGF01161	Nigella aristata	Nigella aristata	Others
BXGF01212	Crotalaria mitchellii	Crotalaria mitchellii	Others
BXGF01325	Murraya exotica	Murraya exotica	Medicinal Plant
BXGF01515	Polypodium vulgare	Polypodium vulgare	Medicinal Plant
BXGF01589	Glycosmis puberula	Glycosmis puberula	Others
BXGF01644	Otanthus maritimus	Otanthus maritimus	Others
BXGF01716	Mentha canadensis	Mentha canadensis	Medicinal Plant
BXGF01758	Cirsium helenioides	Cirsium helenioides	Others
BXGF01786	Berkheya rhapontica	Berkheya rhapontica	Medicinal Plant
BXGF01880	Stevia salicifolia	Stevia salicifolia	Others
BXGF01904	Orthosiphon aristatus	Orthosiphon aristatus	Medicinal Plant
BXGF01916	Clerodendrum cyrtophyllum	Clerodendrum cyrtophyllum	Medicinal Plant
BXGF01924	Handroanthus guayacan	Handroanthus guayacan	Others
BXGF01942	Acanthothamnus aphyllus	Acanthothamnus aphyllus	Others
BXGF01966	Chromolaena odorata	Chromolaena odorata	Medicinal Plant
BXGF01979	Cephalotaxus hainanensis	Cephalotaxus hainanensis	Others
BXGF02047	Vitex rotundifolia	Vitex rotundifolia	Medicinal Plant
BXGF02228	Pterocaulon rugosum	Pterocaulon rugosum	Others
BXGF02249	Ulmus laciniata	Ulmus laciniata	Medicinal Plant
BXGF02592	Ilex affinis	Ilex affinis	Human Edible Plant
BXGF02667	Anaxagorea clavata	Anaxagorea clavata	Others
BXGF02889	Salvia prionitis	Salvia prionitis	Medicinal Plant
BXGF02966	Achillea magnifica	Achillea magnifica	Others
BXGF02977	Jateorhiza palmata	Jateorhiza palmata	Medicinal Plant
BXGF03009	Crinum stuhlmannii	Crinum stuhlmannii	Others
BXGF03016	Ephedra lomatolepis	Ephedra lomatolepis	Others
BXGF03144	Stenostomum lucidum	Stenostomum lucidum	Others
BXGF03147	Beyeria brevifolia	Beyeria brevifolia	Others
BXGF03172	Picradeniopsis oppositifolia	Picradeniopsis oppositifolia	Others
BXGF03252	Tetraria capillaris	Tetraria capillaris	Others
BXGF03292	Maytenus guianensis	Maytenus guianensis	Others
BXGF03314	Saussurea triangulata	Saussurea triangulata	Others
BXGF03324	Phleum africanum	Phleum africanum	Others
BXGF03338	Lindera umbellata	Lindera umbellata	Medicinal Plant
BXGF03347	Stephania succifera	Stephania succifera	Medicinal Plant
BXGF03375	Clausena indica	Clausena indica	Human Edible Plant
BXGF03390	Gentiana olivieri	Gentiana olivieri	Medicinal Plant
BXGF03393	Stypandra imbricata	Stypandra imbricata	Others
BXGF03403	Vernonia serratuloides	Vernonia serratuloides	Others
BXGF03421	Kaempferia pulchra	Kaempferia pulchra	Medicinal Plant
BXGF03432	Chrysanthemum indicum	Chrysanthemum indicum	Medicinal Plant
BXGF03458	Ardisia macrocarpa	Ardisia macrocarpa	Human Edible Plant
BXGF03470	Chlorophytum malayense	Chlorophytum malayense	Medicinal Plant
BXGF03482	Gnetum cleistostachyum	Gnetum cleistostachyum	Others
BXGF03529	Pinus thunbergii	Pinus thunbergii	Medicinal Plant
BXGF03534	Drosera peltata	Drosera peltata	Medicinal Plant
BXGF03543	Teucrium alyssifolium	Teucrium alyssifolium	Others
BXGF03559	Orthosiphon stamineus	Orthosiphon stamineus	Medicinal Plant
BXGF03568	Senecio grandiflorus	Senecio grandiflorus	Others
BXGF03577	Zephyranthes carinata	Zephyranthes carinata	Medicinal Plant
BXGF03597	Angelica ursina	Angelica ursina	Medicinal Plant
BXGF03606	Pinus halepensis	Pinus halepensis	Medicinal Plant
BXGF03712	Arnica nevadensis	Arnica nevadensis	Others
BXGF03745	Odixia angusta	Odixia angusta	Others
BXGF03760	Prunus laurocerasus	Prunus laurocerasus	Medicinal Plant
BXGF03812	Ficus formosana	Ficus formosana	Human Edible Plant
BXGF03843	Dipterocarpus alatus	Dipterocarpus alatus	Medicinal Plant
BXGF03864	Echinops amplexicaulis	Echinops amplexicaulis	Medicinal Plant
BXGF03873	Quercus aegilops	Quercus aegilops	Medicinal Plant
BXGF03883	Chloranthus tianmushanensis	Chloranthus tianmushanensis	Others
BXGF03897	Prosopis glandulosa	Prosopis glandulosa	Human Edible Plant
BXGF03916	Aria pallescens	Aria pallescens	Others
BXGF03926	Simira eliezeriana	Simira eliezeriana	Others
BXGF03928	Celmisia petriei	Celmisia petriei	Others
BXGF03939	Senecio squalidus	Senecio squalidus	Medicinal Plant
BXGF03951	Araujia sericifera	Araujia sericifera	Medicinal Plant
BXGF03966	Artemisia monogyna	Artemisia monogyna	Others
BXGF03986	Epaltes gariepina	Epaltes gariepina	Others
BXGF03991	Seriphidium cinum	Seriphidium cinum	Medicinal Plant
BXGF04002	Dendrosenecio kilimanjari	Dendrosenecio kilimanjari	Others
BXGF04009	Isodon kameba	Isodon kameba	Medicinal Plant
BXGF04016	Pterocarpus grandiflorus	Pterocarpus grandiflorus	Others
BXGF04030	Chromolaena pulchella	Chromolaena pulchella	Others
BXGF04041	Bursaria spinosa	Bursaria spinosa	Human Edible Plant
BXGF04054	Taxodium mucronatum	Taxodium mucronatum	Medicinal Plant
BXGF04066	Gardenia fosbergii	Gardenia fosbergii	Others
BXGF04073	Vitex madiensis	Vitex madiensis	Medicinal Plant
BXGF04144	Agnorhiza bolanderi	Agnorhiza bolanderi	Others
BXGF04299	Cladrastis kentukea	Cladrastis kentukea	Others
BXGF04382	Murraya paniculata	Murraya paniculata	Medicinal Plant
BXGF04611	Artemisia argyi	Artemisia argyi	Medicinal Plant
BXGF04708	Sesbania punicea	Sesbania punicea	Others
BXGF04844	Primula veris	Primula veris	Medicinal Plant
BXGF05000	Citrus reticulate	Citrus reticulate	Others
BXGF05110	Euonymus maackii	Euonymus maackii	Others
BXGF05190	Ferula gummosa	Ferula gummosa	Medicinal Plant
BXGF05321	Dracaena ombet	Dracaena ombet	Others
BXGF05376	Eschscholzia californica	Eschscholzia californica	Medicinal Plant
BXGF05469	Pseudoxandra sclerocarpa	Pseudoxandra sclerocarpa	Others
BXGF05481	Populus tremula	Populus tremula	Medicinal Plant
BXGF05550	Morus yunnanensis	Morus yunnanensis	Others
BXGF05553	Astragalus inopinatus	Astragalus inopinatus	Others
BXGF05704	Securidaca inappendiculata	Securidaca inappendiculata	Medicinal Plant
BXGF05773	Myrica arborea	Myrica arborea	Others
BXGF05821	Nicotiana gossei	Nicotiana gossei	Medicinal Plant
BXGF05843	Pteris prolifera	Pteris prolifera	Others
BXGF05856	Isodon leucophyllus	Isodon leucophyllus	Medicinal Plant
BXGF05857	Iris domestica	Iris domestica	Medicinal Plant
BXGF06013	Iryanthera polyneura	Iryanthera polyneura	Others
BXGF06125	Senecio integerrimus	Senecio integerrimus	Others
BXGF06199	Polygala aureocauda	Polygala aureocauda	Others
BXGF06277	Vincetoxicum hirundinaria	Vincetoxicum hirundinaria	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}