Showing entry for Cytochrome P450 1B1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013656
Protein NameCytochrome P450 1B1
Uniport IdQ16678
GeneCYP1B1
Gene Id1545
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00380 Tryptophan metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0048514 blood vessel morphogenesis
Biological Process GO:0007155 cell adhesion
Biological Process GO:0006725 cellular aromatic compound metabolic process
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0071603 endothelial cell-cell adhesion
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0019373 epoxygenase P450 pathway
Biological Process GO:0008210 estrogen metabolic process
Biological Process GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
Biological Process GO:0046466 membrane lipid catabolic process
Biological Process GO:0033629 negative regulation of cell adhesion mediated by integrin
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0032088 negative regulation of NF-kappaB transcription factor activity
Biological Process GO:0006809 nitric oxide biosynthetic process
Biological Process GO:0097267 omega-hydroxylase P450 pathway
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0010575 positive regulation of vascular endothelial growth factor production
Biological Process GO:2000377 regulation of reactive oxygen species metabolic process
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0061304 retinal blood vessel morphogenesis
Biological Process GO:0042574 retinal metabolic process
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0008202 steroid metabolic process
Biological Process GO:0016125 sterol metabolic process
Biological Process GO:0009404 toxin metabolic process
Biological Process GO:0002930 trabecular meshwork development
Biological Process GO:0007601 visual perception
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0070330 aromatase activity
molecular function GO:0101020 estrogen 16-alpha-hydroxylase activity
molecular function GO:0020037 heme binding
molecular function GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
molecular function GO:0005506 iron ion binding
molecular function GO:0004497 monooxygenase activity
molecular function GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
molecular function GO:0019825 oxygen binding
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-556833 Metabolism of lipids
R-HSA-5579000 Defective CYP1B1 causes Glaucoma
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000786 BXGD000010 Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003076 BXGD000171 Aniridia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007104 BXGD000427 Female Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007117 BXGD000433 Basal cell carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009363 BXGD000599 Congenital ocular coloboma (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013592 BXGD000857 Ectropion Eye Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016034 BXGD001034 Breast Fibrocystic Disease Skin and Connective Tissue Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017605 BXGD001126 Angle Closure Glaucoma Eye Diseases
C0017606 BXGD001127 Primary angle-closure glaucoma Eye Diseases
C0017612 BXGD001129 Glaucoma, Open-Angle Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018671 BXGD001211 Head and Neck Neoplasms Neoplasms
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020302 BXGD001373 Hydrophthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021171 BXGD001488 Bloch Sulzberger syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023453 BXGD001652 L2 Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026640 BXGD001912 Mouth Neoplasms Neoplasms; Stomatognathic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033027 BXGD002388 Preleukemia Neoplasms; Hemic and Lymphatic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0035302 BXGD002527 Retinal Artery Occlusion Eye Diseases; Cardiovascular Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035328 BXGD002537 Retinal Vein Occlusion Eye Diseases; Cardiovascular Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038505 BXGD002765 Sturge-Weber Syndrome Neoplasms; Nervous System Diseases; Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0043346 BXGD003043 Xeroderma Pigmentosum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085109 BXGD003125 Corneal Neovascularization Pathological Conditions, Signs and Symptoms; Eye Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0152136 BXGD003548 Low Tension Glaucoma Eye Diseases
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152252 BXGD003572 Anterior synechiae Pathological Conditions, Signs and Symptoms
C0152253 BXGD003573 Posterior synechiae Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0153535 BXGD003661 Malignant melanoma of skin of upper limb Neoplasms; Skin and Connective Tissue Diseases
C0153536 BXGD003662 Malignant melanoma of skin of lower limb Neoplasms; Skin and Connective Tissue Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205646 BXGD004098 Adenoma, Basal Cell Neoplasms
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0205648 BXGD004100 Adenoma, Microcystic Neoplasms
C0205649 BXGD004101 Adenoma, Monomorphic Neoplasms
C0205650 BXGD004102 Papillary adenoma Neoplasms
C0205651 BXGD004103 Adenoma, Trabecular Neoplasms
C0206669 BXGD004229 Hepatocellular Adenoma Digestive System Diseases; Neoplasms
C0206710 BXGD004258 Basal Cell Neoplasm Neoplasms
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235259 BXGD004735 Subcapsular cataract Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235653 BXGD004762 Malignant neoplasm of female breast Neoplasms; Skin and Connective Tissue Diseases
C0235752 BXGD004766 Port-Wine Stain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236075 BXGD004810 Menopausal symptom
C0238033 BXGD004861 Carcinoma of Male Breast Neoplasms; Skin and Connective Tissue Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0238694 BXGD004953 Peripheral arthritis Musculoskeletal Diseases
C0241688 BXGD005107 Peripheral visual field loss
C0241880 BXGD005120 Endometriosis of pelvis Female Urogenital Diseases and Pregnancy Complications
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242787 BXGD005195 Malignant neoplasm of male breast Neoplasms; Skin and Connective Tissue Diseases; Endocrine System Diseases
C0265341 BXGD005524 Rieger syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0266525 BXGD005686 Irido-corneal dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0268381 BXGD005922 Primary amyloidosis Neoplasms; Nutritional and Metabolic Diseases; Immune System Diseases
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278601 BXGD006547 Inflammatory Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0311237 BXGD006868 Goniodysgenesis
C0311251 BXGD006870 Simple buphthalmos
C0334294 BXGD007025 Multiple adenomatous polyps Neoplasms
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0343641 BXGD007636 Human papilloma virus infection Infections
C0344299 BXGD007663 Temporal pallor of optic disc Eye Diseases; Nervous System Diseases
C0344559 BXGD007695 Irido-corneo-trabecular dysgenesis (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0345326 BXGD007727 Congenital phimosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0403766 BXGD008309 Acquired phimosis Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0406208 BXGD008330 Suntan
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0521158 BXGD009130 Recurrent tumor
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596321 BXGD009642 Chemical Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600142 BXGD009696 Hot flushes Pathological Conditions, Signs and Symptoms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0741682 BXGD010039 Premenopausal breast cancer
C0745744 BXGD010133 End Stage Liver Disease Digestive System Diseases
C0751676 BXGD010549 Basal Cell Cancer Neoplasms
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0796176 BXGD010809 STUVE-WIEDEMANN SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases
C0812437 BXGD010850 Oculo-dento-digital syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0856901 BXGD011124 Retinol Deficiency Nutritional and Metabolic Diseases
C0857112 BXGD011136 Bilateral glaucoma Eye Diseases
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1274700 BXGD012040 Postmenopausal frontal fibrosing alopecia
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1299694 BXGD012264 Glaucomatous visual field defect
C1304119 BXGD012325 Chronic stable plaque psoriasis
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1333001 BXGD012578 Childhood Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1527390 BXGD013285 Neoplasms, Intracranial Neoplasms; Nervous System Diseases
C1533041 BXGD013307 Primary congenital glaucoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1536999 BXGD013348 cancer angiogenesis
C1608408 BXGD013434 Malignant transformation
C1611743 BXGD013456 Familial (FPAH)
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1827377 BXGD013770 Slow acetylator due to N-acetyltransferase enzyme variant
C1832977 BXGD013891 GLAUCOMA 3, PRIMARY INFANTILE, B Eye Diseases
C1842028 BXGD014488 GLAUCOMA 1, OPEN ANGLE, A Eye Diseases
C1856439 BXGD015607 GLAUCOMA 3, PRIMARY CONGENITAL, A Eye Diseases
C1856441 BXGD015608 Late onset congenital glaucoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1858556 BXGD015805 OVERLAP CONNECTIVE TISSUE DISEASE Eye Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1862382 BXGD016125 SVEINSSON CHORIORETINAL ATROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1862389 BXGD016126 ATRIAL SEPTAL DEFECT 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1862839 BXGD016137 Anterior segment mesenchymal dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1865427 BXGD016327 GLAUCOMA 1, OPEN ANGLE, D (disorder) Eye Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931456 BXGD018024 Prostate cancer, familial Neoplasms; Male Urogenital Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C2981140 BXGD018209 Glaucoma of childhood Eye Diseases
C3152182 BXGD018461 Anterior chamber anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3278153 BXGD018729 GLAUCOMA, PRIMARY OPEN ANGLE, JUVENILE-ONSET
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3495489 BXGD018988 Rieger eye malformation sequence Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3711383 BXGD019388 Early-Onset Glaucoma Eye Diseases
C3805911 BXGD019493 Increased cup-to-disc ratio
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4016760 BXGD020372 GLAUCOMA, EARLY-ONSET, DIGENIC
C4023327 BXGD021153 Central opacification of the cornea
C4023330 BXGD021155 Abnormal Descemet membrane morphology
C4025845 BXGD021825 Abnormality iris morphology
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4068743 BXGD022002 Juvenile open angle
C4072686 BXGD022004 Cardiovascular disease+Pulmonary disease
C4085595 BXGD022120 AL-RAQAD SYNDROME
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4255374 BXGD022314 Frontal fibrosing alopecia
C4282128 BXGD022420 PATENT DUCTUS ARTERIOSUS 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4310623 BXGD022603 ANTERIOR SEGMENT DYSGENESIS 6
C4310809 BXGD022675 ANTERIOR SEGMENT DYSGENESIS 5
C4477011 BXGD022903 Thinning of Descemet membrane
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4551507 BXGD023327 Buphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4552100 BXGD023488 Lynch Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721779 BXGD023769 Ovarian cancer stage IV
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722328 BXGD023800 Hereditary Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000314 Isorhamnetin 316.26
BXGC0000340 Kaempferol 286.24
BXGC0000363 Galangin 270.24
BXGC0000365 Medicarpin 270.28
BXGC0000378 (S)-4',7-Dihydroxy-3',8-diprenylflavanone 392.49
BXGC0000379 3-Hydroxyglabrol 408.49
BXGC0000383 (S)-Naringenin 272.25
BXGC0000516 Diosmetin 300.26
BXGC0000642 4-Aminobenzoic acid 137.14
BXGC0001026 Eupatorin 344.32
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001778 Scutellarein 286.24
BXGC0001842 Bergapten 216.19
BXGC0001876 Chrysoeriol 300.26
BXGC0001962 Hesperetin 302.28
BXGC0002043 Acacetin 284.26
BXGC0002071 Apigenin 270.24
BXGC0002610 Aniline 93.13
BXGC0002789 Isoimperatorin 270.28
BXGC0002801 Phellopterin 300.31
BXGC0002916 Melatonin 232.28
BXGC0003487 Plumbagin 188.18
BXGC0003776 Flavones 222.24
BXGC0003810 Cirsilion 330.29
BXGC0003813 Genkwanin 284.26
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0005584 4'-O-Methylglabridin 338.4
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0005915 Formononetin 268.27
BXGC0005919 Biochanin A 284.27
BXGC0006259 Isopimpinellin 246.22
BXGC0006306 Myricetin 318.24
BXGC0006326 Imperatorin 270.28
BXGC0006362 Estrone 270.37
BXGC0006635 Luteolin 286.24
BXGC0007810 p-Mentha-1,8-dien-7-ol 152.24
BXGC0008167 Chrysin 254.24
BXGC0008676 Haem 616.49
BXGC0008707 Isoliquiritigenin 256.25
BXGC0008747 Tamarixetin 316.26
BXGC0008840 Kaempferide 300.26
BXGC0008973 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether 358.34
BXGC0011627 Glycyrrhetic acid 470.69
BXGC0014707 Dehydroevodiamine 302.13
BXGC0014947 Glabridin 324.14
BXGC0015681 (E)-3,4,3',5'-Tetramethoxystilbene 300.14
BXGC0017248 Evodiamine 303.14
BXGC0018882 Liquirtigenin 256.07
BXGC0020302 Hortiacine 317.12
BXGC0020800 Testosterone 288.21
BXGC0021403 Cannabinol 310.19
BXGC0023497 Pterostilbene 256.11
BXGC0025017 Bergamottin 338.15
BXGC0025887 5-Hydroxyflavone 238.06
BXGC0026595 Glycyrrhizin 822.4
BXGC0028278 Rutaecarpine 287.11
BXGC0031425 Homoeriodictyol 302.08
BXGC0031717 Purpurin 256.04
BXGC0032310 Pinocembrin 256.07
BXGC0032684 Pyrene 202.08
BXGC0036691 Isosakutanetin 286.08
BXGC0037482 3-[(E)-2-(4-Hydroxyphenyl)Ethenyl]-5-Methoxyphenol 242.09
BXGC0039083 Pinosylvin 212.08
BXGC0039172 Oxyresveratrol 244.07
BXGC0039397 Athraquinones A 240.04
BXGC0039476 Eriodictyol 288.06
BXGC0039750 Resveratrol 4'-Methyl Ether 242.09
BXGC0040150 Cannabidiol 314.22
BXGC0041820 Schisantherin E 538.22
BXGC0042510 Fluoxetine 309.13
BXGC0044218 demethyleneberberine 324.12
BXGC0045292 11-Methoxyrutecarprine 317.12
BXGC0047281 Berberine 336.12
BXGC0047871 7-Hydroxyflavone 238.06
BXGC0048123 thalifendine 322.11
BXGC0049147 2-Methoxyruteacaprine 317.12
BXGC0051357 Trismethoxyresveratrol 270.13
BXGC0052224 Ginsenoside Rh2 622.44
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein