Showing entry for L-glutamine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0012340
Compound NameL-glutamine
Structure
FormulaC5H10N2O3
InchiKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILESN[C@@H](CCC(N)=O)C(O)=O
InchiInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
IUPAC(2S)-2-amino-4-carbamoylbutanoic acid
Molecular Weight146.14
Pubchem Id5961
Chembl IdCHEMBL930
Targets of Information Source
DrugBank DB00130
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P17812 BXGT008345 CTP synthase 1 reviewed Enzyme CTPS1 approved; investigational; nutraceutical antagonist,substrate
Q06203 BXGT012862 Amidophosphoribosyltransferase reviewed Enzyme PPAT approved; investigational; nutraceutical substrate
P15104 BXGT008081 Glutamine synthetase reviewed Enzyme GLUL approved; investigational; nutraceutical product of
PDB GLN
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00968 BXGT005708 Carbamoyl-phosphate synthase large chain reviewed carB - - - - -
P0A6F1 BXGT007050 Carbamoyl-phosphate synthase small chain reviewed carA - - - - -
P22106 BXGT008732 Asparagine synthetase B [glutamine-hydrolyzing] reviewed asnB - - - - -
P00962 BXGT005705 Glutamine--tRNA ligase reviewed glnS - - - - -
Q9WYV8 BXGT022005 Release factor glutamine methyltransferase reviewed prmC - - - - -
Q5SIA8 BXGT015709 CTP synthase reviewed pyrG - - - - -
P0AEQ3 BXGT007325 Glutamine-binding periplasmic protein reviewed glnH - - - 500 -
P22262 BXGT008749 Listeriolysin regulatory protein reviewed prfA - - - - -
O59188 BXGT004838 Uncharacterized HTH-type transcriptional regulator PH1519 reviewed fl11 - - - - -
F9VNT4 BXGT003359 Glutamine receptor protein unreviewed grp - - - - -
P63488 BXGT011524 Glutamyl-tRNA(Gln) amidotransferase subunit A reviewed gatA - - - - -
P37528 BXGT009992 Pyridoxal 5'-phosphate synthase subunit PdxT reviewed pdxT - - - - -
Q71RI9 BXGT016702 Kynurenine--oxoglutarate transaminase 3 reviewed Kyat3 - - - - -
O66610 BXGT004952 Glutamyl-tRNA(Gln) amidotransferase subunit A reviewed gatA - - - - -
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed GLS Enzyme - - - -
Q9X0C8 BXGT022056 Imidazole glycerol phosphate synthase subunit HisH reviewed hisH - - - - -
Q837U7 BXGT017476 Putrescine carbamoyltransferase reviewed ptcA - - - - -
Q837S0 BXGT017475 Amino acid ABC transporter, amino acid-binding/permease protein unreviewed EF_0761 - - - 130 -
Q9CES5 BXGT020233 Glutamine ABC transporter permease and substrate binding protein protein unreviewed glnP - - - 1490 -
P82610 BXGT011983 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase reviewed MET6 - - - - -
P12425 BXGT007813 Glutamine synthetase reviewed glnA - - - - -
Q03557 BXGT012728 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial reviewed HER2 - - - - -
P12296 BXGT007793 Genome polyprotein reviewed - - - - -
A8JI83 BXGT001706 Nitrogen regulatory protein PII unreviewed GLB1 - - - - -
Q8IJR9 BXGT018293 GMP synthase [glutamine-hydrolyzing] unreviewed PF3D7_1012600 - - - - -
Q9RQJ2 BXGT021484 Peptidylarginine deiminase reviewed PG_1424 - - - - -
Q837S0 BXGT017475 Amino acid ABC transporter, amino acid-binding/permease protein unreviewed EF_0761 - - - - -
A0R5M9 BXGT000954 Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase reviewed egtC - - - - -
P12821 BXGT007849 Angiotensin-converting enzyme reviewed ACE Enzyme - - - -
A0A0H2YM47 BXGT000329 Periplasmic dipeptide transport protein unreviewed YPN_3652 - - - - -
N1P8Q8 BXGT003874 Nta1p unreviewed CENPK1137D_1355 - - - - -
Q9HW91 BXGT020630 Methyl-accepting chemotaxis protein PctB reviewed pctB - - - - -
A0A0H2WZ38 BXGT000319 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD reviewed gatD - - - - -
P02994 BXGT006002 Elongation factor 1-alpha reviewed TEF1 - - - - -
P02911 BXGT005987 Lysine/arginine/ornithine-binding periplasmic protein reviewed argT - - - 1590 -
P0A7E5 BXGT007112 CTP synthase reviewed pyrG - - - - -
O22822 BXGT004216 UDP-glycosyltransferase 74F2 reviewed UGT74F2 - - - - -
A0A173M0G2 BXGT000691 Taste receptor, type 1, member 2a unreviewed TAS1R2a - - - - -
A0A173M094 BXGT000690 Taste receptor, type 1, member 3 unreviewed TAS1R3 - - - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed CYP3A4 Enzyme - - - -
Q8DNZ8 BXGT018005 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD reviewed gatD - - - - -
Q15758 BXGT013594 Neutral amino acid transporter B(0) reviewed SLC1A5 Transporter - - - -
P40969 BXGT010213 Centromere DNA-binding protein complex CBF3 subunit B reviewed CEP3 - - - - -
O11424 BXGT024374 Fiber protein unreviewed - - - - -
H8Y6N2 BXGT003629 CrmG unreviewed - - - - -
P74881 BXGT011742 Phosphoribosylformylglycinamidine synthase reviewed purL - - - - -
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed KMT2A - - - - -
P9WJJ2 BXGT025069 Glutamine-dependent NAD(+) synthetase reviewed nadE - - - - -
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase reviewed QPCT Enzyme - - - -
Binding DB 18121
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 - >10000 - -
CHEMBL CHEMBL930
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 1778 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 4744 nM
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity - - -
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 39810 nM
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 84921 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 10000 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 2 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 31622 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '>' 10000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 IC50 '=' 41000 nM
P43007 BXGT010350 Neutral amino acid transporter A reviewed Transporter SLC1A4 IC50 '=' 3373000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 IC50 '=' 26900 nM
Q4CVY4 BXGT026093 Carbonic anhydrase-like protein, putative unreviewed - Tc00.1047053509597.20 KA '=' 2 uM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 14125 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 151 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 5358 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 KA '>' 100 uM
P63116 BXGT011501 Asc-type amino acid transporter 1 reviewed - Slc7a10 IC50 '=' 943000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 IC50 '=' 4713000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 Inhibition - - -
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 IC50 '=' 2737000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 IC50 '=' 1641000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 Inhibition '>=' 25 %
Q15758 BXGT013594 Neutral amino acid transporter B(0) reviewed Transporter SLC1A5 IC50 '=' 541000 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 KA '>' 50 uM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00006 Garden onion Allium cepa Vegetables
BXGF00008 Garlic Allium sativum Herbs and Spices
BXGF00013 Dill Anethum graveolens Herbs and Spices
BXGF00022 Oat Avena sativa Cereals and cereal products
BXGF00034 Broccoli Brassica oleracea var. italica Vegetables
BXGF00036 Turnip Brassica rapa var. rapa Herbs and Spices
BXGF00065 Cucumber Cucumis sativus Gourds
BXGF00088 Barley Hordeum vulgare Cereals and cereal products
BXGF00129 Parsnip Pastinaca sativa Vegetables
BXGF00169 Rye Secale cereale Cereals and cereal products
BXGF00174 Eggplant Solanum melongena Vegetables
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00178 Spinach Spinacia oleracea Vegetables
BXGF00225 Swiss chard Beta vulgaris ssp. cicla Vegetables
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00246 Red beetroot Beta vulgaris var. rubra Vegetables
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00459 Wax gourd Benincasa hispida Gourds
BXGF00519 Wheat Triticum Cereals and cereal products
BXGF00826 Sunburst squash (pattypan squash) Cucurbita pepo var. clypeata Gourds
BXGF00827 Green zucchini Cucurbita pepo var. cylindrica Gourds
BXGF00828 Yellow zucchini Cucurbita pepo var. cylindrica Gourds
BXGF00829 Green bell pepper Capsicum annuum Vegetables
BXGF00830 Yellow bell pepper Capsicum annuum Vegetables
BXGF00831 Orange bell pepper Capsicum annuum Vegetables
BXGF00832 Red bell pepper Capsicum annuum Vegetables
BXGF00834 Yellow wax bean Phaseolus vulgaris Pulses
BXGF00835 Green bean Phaseolus vulgaris Pulses
BXGF00836 Saskatoon berry Amelanchier alnifolia Fruits
BXGF00837 Nanking cherry Prunus tomentosa Fruits
BXGF00838 Japanese pumpkin Cucurbita maxima Gourds
BXGF00839 White cabbage Brassica oleracea L. var. capitata L. f. alba DC. Vegetables
BXGF00840 Romaine lettuce Lactuca sativa L. var. longifolia Vegetables
BXGF00892 Leptocereus quadricostatus Leptocereus quadricostatus Others
BXGF00919 Chaiturus marrubiastrum Chaiturus marrubiastrum Others
BXGF01187 Onobrychis arenaria Onobrychis arenaria Others
BXGF01311 Aizopsis selskiana Aizopsis selskiana Others
BXGF01570 Pinalia stricta Pinalia stricta Others
BXGF01623 Amphorogyne spicata Amphorogyne spicata Others
BXGF01695 Tanacetum coccineum Tanacetum coccineum Medicinal Plant
BXGF01799 Mandragora autumnalis Mandragora autumnalis Medicinal Plant
BXGF01911 Bupleurum scorzonerifolium Bupleurum scorzonerifolium Medicinal Plant
BXGF01931 Dalbergia lanceolaria subsp. paniculata Dalbergia lanceolaria subsp. paniculata Medicinal Plant
BXGF02037 Carduus tenuiflorus Carduus tenuiflorus Others
BXGF02203 Verbascum thapsiforme Verbascum thapsiforme Medicinal Plant
BXGF02289 Rhododendron dahuricum Rhododendron dahuricum Others
BXGF02387 Salvia greggii Salvia greggii Medicinal Plant
BXGF02503 Balanophora laxiflora Balanophora laxiflora Others
BXGF02576 Anaphalis lactea Anaphalis lactea Others
BXGF02632 Metrodorea nigra Metrodorea nigra Others
BXGF02814 Senecio praecox Senecio praecox Others
BXGF02853 Anchusa azurea Anchusa azurea Medicinal Plant
BXGF02880 Nepeta granatensis Nepeta granatensis Others
BXGF02900 Gleichenia quadripartita Gleichenia quadripartita Others
BXGF02932 Dipsacus azureus Dipsacus azureus Others
BXGF02958 Jacquemontia paniculata Jacquemontia paniculata Others
BXGF02993 Caulerpa peltata Caulerpa peltata Human Edible Plant
BXGF03028 Lespedeza tomentosa Lespedeza tomentosa Medicinal Plant
BXGF03042 Rosa pomifera Rosa pomifera Human Edible Plant
BXGF03064 Degenia velebitica Degenia velebitica Others
BXGF03077 Albizia myriophylla Albizia myriophylla Medicinal Plant
BXGF03088 Erythrophleum ivorense Erythrophleum ivorense Medicinal Plant
BXGF03114 Delphinium virgatum Delphinium virgatum Others
BXGF03135 Grangea maderaspatana Grangea maderaspatana Medicinal Plant
BXGF03158 Rheum officinale Rheum officinale Medicinal Plant
BXGF03167 Tagetes filifolia Tagetes filifolia Medicinal Plant
BXGF03217 Delphinium nuttallianum Delphinium nuttallianum Others
BXGF03251 Lupinus corymbosus Lupinus corymbosus Others
BXGF03298 Senecio behnii Senecio behnii Others
BXGF03317 Dillenia indica Dillenia indica Medicinal Plant
BXGF03436 Photinia serratifolia Photinia serratifolia Medicinal Plant
BXGF03512 Helichrysum chionosphaerum Helichrysum chionosphaerum Medicinal Plant
BXGF04229 Petunia integrifolia subsp. inflata Petunia integrifolia subsp. inflata Others
BXGF04340 Quercus rubra Quercus rubra Medicinal Plant
BXGF04875 Bupleurum chinense Bupleurum chinense Medicinal Plant
BXGF04981 Bupleurum falcatum Bupleurum falcatum Medicinal Plant
BXGF05017 Karwinskia parvifolia Karwinskia parvifolia Others
BXGF05203 Chlamydomonas reinhardtii Chlamydomonas reinhardtii Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease