Showing entry for (2S,3S)-2-Amino-3-Hydroxybutanedioic Acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0014019
Compound Name(2S,3S)-2-Amino-3-Hydroxybutanedioic Acid
Structure
FormulaC4H7NO5
InchiKeyYYLQUHNPNCGKJQ-LWMBPPNESA-N
SMILESOC(=O)[C@H]([C@@H](C(=O)O)N)O
InchiInChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
IUPAC(2S,3S)-2-amino-3-hydroxybutanedioic acid
Molecular Weight149.03
Pubchem Id443239
Chembl IdCHEMBL1231330
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 85209
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008490 Glutamate receptor 3 reviewed Gria3 >10000 - - -
reviewed BXGT008804 Glutamate receptor ionotropic, kainate 1 reviewed Grik1 >10000 - - -
reviewed BXGT009831 Glutamate receptor ionotropic, NMDA 1 reviewed Grin1 >10000 - - -
CHEMBL CHEMBL1231330
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 31 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 39810 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 39810 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 50118 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 89125 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 12589 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 4107 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 31 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 3548 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 26679 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 28 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 35481 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 19011 nM
P43004 BXGT010348 Excitatory amino acid transporter 2 reviewed Transporter SLC1A2 IC50 '=' 9600 nM
P43003 BXGT010347 Excitatory amino acid transporter 1 reviewed Transporter SLC1A3 IC50 '=' 3890 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 3548 nM
P43005 BXGT010349 Excitatory amino acid transporter 3 reviewed Transporter SLC1A1 IC50 '=' 9600 nM
P43004 BXGT010348 Excitatory amino acid transporter 2 reviewed Transporter SLC1A2 IC50 '=' 9549 nM
O35921 BXGT026125 Excitatory amino acid transporter 4 reviewed - Slc1a6 IC50 '=' 2800 nM
P43003 BXGT010347 Excitatory amino acid transporter 1 reviewed Transporter SLC1A3 IC50 '=' 3900 nM
O35921 BXGT026125 Excitatory amino acid transporter 4 reviewed - Slc1a6 IC50 '=' 2818 nM
P43005 BXGT010349 Excitatory amino acid transporter 3 reviewed Transporter SLC1A1 IC50 '=' 9549 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF06185 Ophiopogon japonicus Ophiopogon japonicus Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease